AutismKB 2.0

Annotation Detail for BRF1


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Basic Information Top
Gene Symbol:BRF1 ( BRF,FLJ42674,FLJ43034,GTF3B,MGC105048,TAF3B2,TAF3C,TAFIII90,TF3B90,TFIIIB90,hBRF )
Gene Full Name: BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)
Band: 14q32.33
Quick LinksEntrez ID:2972; OMIM: 604902; Uniprot ID:TF3B_HUMAN; ENSEMBL ID: ENSG00000185024; HGNC ID: 11551
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst2 / 6231932
fetus50 / 56401288
neonate0 / 310970 
infant2 / 2362084
juvenile0 / 555560 
adult55 / 193912128
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor5 / 9417853
cervical tumor2 / 3436658
chondrosarcoma5 / 8282360
colorectal tumor3 / 11424626
esophageal tumor3 / 17290173
gastrointestinal tumor4 / 11936933
germ cell tumor18 / 26384568
glioma14 / 106883130
head and neck tumor5 / 13630236
kidney tumor3 / 6895943
leukemia6 / 9584262
liver tumor2 / 9635920
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia3 / 9725030
normal167 / 336030749
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS8 / 12568063
prostate cancer8 / 10268077
retinoblastoma0 / 463560 
skin tumor30 / 124949240
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites2 / 4001549
bladder1 / 2975733
blood1 / 1234788
bone3 / 7165541
bone marrow0 / 488010 
brain120 / 1100989108
cervix2 / 4817141
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus3 / 20209148
eye9 / 21105442
heart1 / 8962611
intestine9 / 23447238
kidney4 / 21177718
larynx1 / 2414541
liver2 / 2077439
lung11 / 33697432
lymph0 / 442700 
lymph node6 / 9161065
mammary gland6 / 15327139
mouth1 / 6705214
muscle3 / 10771527
nerve2 / 15768126
ovary4 / 10205139
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland2 / 16585120
placenta3 / 28082510
prostate9 / 18934547
salivary gland1 / 2015549
skin30 / 210574142
spleen1 / 5395218
stomach0 / 966190 
testis15 / 33044245
thymus3 / 8113136
thyroid4 / 4747384
tonsil1 / 1699958
trachea5 / 5241395
umbilical cord0 / 136800 
uterus6 / 23287825
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 215677_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.4
Adipocyte3.45
AdrenalCortex3.65
Adrenalgland2.95
Amygdala3.7
Appendix3.55
AtrioventricularNode2.7
BDCA4+_DentriticCells3.9
Bonemarrow3.45
BronchialEpithelialCells3.45
CD105+_Endothelial3.55
CD14+_Monocytes3.75
CD19+_BCells(neg._sel.)3.95
CD33+_Myeloid4.5
CD34+4.5
CD4+_Tcells3.85
CD56+_NKCells4.2
CD71+_EarlyErythroid3.25
CD8+_Tcells3.4
CardiacMyocytes4.5
Caudatenucleus3.15
Cerebellum2.8
CerebellumPeduncles4.05
CiliaryGanglion2.45
CingulateCortex3.6
Colorectaladenocarcinoma3.5
DorsalRootGanglion2.65
FetalThyroid3.4
Fetalbrain3.5
Fetalliver3.05
Fetallung2.9
GlobusPallidus2.6
Heart5.1
Hypothalamus3.8
Kidney2.8
Leukemia_chronicMyelogenousK-5623.15
Leukemia_promyelocytic-HL-603.1
Leukemialymphoblastic(MOLT-4)2.8
Liver4.65
Lung3.85
Lymphnode3
Lymphoma_burkitts(Daudi)4.5
Lymphoma_burkitts(Raji)4.95
MedullaOblongata3.2
OccipitalLobe3.15
OlfactoryBulb2.75
Ovary2.3
Pancreas2.8
PancreaticIslet3.7
ParietalLobe3.7
Pituitary4.1
Placenta3.6
Pons3.3
PrefrontalCortex4.35
Prostate4.1
Salivarygland2.8
SkeletalMuscle4.05
Skin2.7
SmoothMuscle4
Spinalcord3.75
SubthalamicNucleus3.2
SuperiorCervicalGanglion3.95
TemporalLobe3.2
Testis3
TestisGermCell2.95
TestisIntersitial2.95
TestisLeydigCell3.45
TestisSeminiferousTubule3
Thalamus3.55
Thymus2.75
Thyroid4.4
Tongue3.4
Tonsil3.4
Trachea2.9
TrigeminalGanglion3.5
Uterus2.85
UterusCorpus3.15
WholeBlood3.85
Wholebrain2.95
colon3.5
pineal_day4.4
pineal_night4.32
retina4.25
small_intestine3.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P117416
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.35 ± 0.27
Basal Forebrain7.61 ± 0.27
Basal Part of Pons7.62 ± 0.29
Cerebellar Cortex7.7 ± 0.4
Cerebellar Nuclei7.66 ± 0.27
Claustrum7.36 ± 0.27
Epithalamus7.65 ± 0.35
Frontal Lobe7.58 ± 0.3
Globus Pallidus7.37 ± 0.2
Hypothalamus7.31 ± 0.77
Insula7.47 ± 0.27
Limbic Lobe7.51 ± 0.27
Mesencephalon7.6 ± 0.24
Myelencephalon7.62 ± 0.3
Occipital Lobe7.72 ± 0.26
Parietal Lobe7.58 ± 0.26
Pontine Tegmentum7.52 ± 0.32
Striatum7.4 ± 0.25
Subthalamus7.62 ± 0.02
Temporal Lobe7.61 ± 0.27
Thalamus7.64 ± 0.23
White Matter7.92 ± 0.2
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Brf1CBCerebellum50.39
57.38
Brf1CTXCerebral cortex55.92
41.85
Brf1HIPHippocampal region49.07
69.88
Brf1HPFHippocampal formation51.57
60.65
Brf1HYHypothalamus6.3
5
Brf1LSXLateral septal complex6.93
4.85
Brf1MBMidbrain13.2
11.7
Brf1MYMedulla26.32
25.21
Brf1OLFOlfactory bulb57.86
51.75
Brf1PPons13.35
13.25
Brf1PALPallidum10
8.83
Brf1RHPRetrohippocampal region56.39
49.26
Brf1sAMYStriatum-like amygdalar nuclei24.71
17.73
Brf1STRStriatum22.77
16.88
Brf1STRdStriatum dorsal region24.37
18.23
Brf1STRvStriatum ventral region20.63
14.96
Brf1THThalamus14.2
11.74
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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