AutismKB 2.0

Annotation Detail for GUCY1A3


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Basic Information Top
Gene Symbol:GUCY1A3 ( GC-SA3,GUC1A3,GUCA3,GUCSA3,GUCY1A1 )
Gene Full Name: guanylate cyclase 1, soluble, alpha 3
Band: 4q32.1
Quick LinksEntrez ID:2982; OMIM: 139396; Uniprot ID:GCYA3_HUMAN; ENSEMBL ID: ENSG00000164116; HGNC ID: 4685
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body8 / 70761113
blastocyst0 / 623190 
fetus84 / 564012148
neonate1 / 3109732
infant0 / 236200 
juvenile2 / 5555635
adult124 / 193912163
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor5 / 26384518
glioma0 / 1068830 
head and neck tumor3 / 13630222
kidney tumor9 / 68959130
leukemia6 / 9584262
liver tumor1 / 9635910
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia5 / 9725051
normal265 / 336030778
ovarian tumor5 / 7668265
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer15 / 102680146
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites0 / 400150 
bladder1 / 2975733
blood0 / 1234780 
bone4 / 7165555
bone marrow5 / 48801102
brain129 / 1100989117
cervix0 / 481710 
connective tissue5 / 14925533
ear1 / 1621261
embryonic tissue10 / 21572246
esophagus0 / 202090 
eye23 / 211054108
heart10 / 89626111
intestine11 / 23447246
kidney20 / 21177794
larynx1 / 2414541
liver3 / 20774314
lung10 / 33697429
lymph0 / 442700 
lymph node4 / 9161043
mammary gland8 / 15327152
mouth2 / 6705229
muscle5 / 10771546
nerve1 / 1576863
ovary3 / 10205129
pancreas11 / 21481251
parathyroid0 / 205390 
pharynx2 / 4132848
pituitary gland1 / 1658560
placenta16 / 28082556
prostate23 / 189345121
salivary gland0 / 201550 
skin2 / 2105749
spleen4 / 5395274
stomach2 / 9661920
testis1 / 3304423
thymus2 / 8113124
thyroid1 / 4747321
tonsil0 / 169990 
trachea5 / 5241395
umbilical cord1 / 1368073
uterus4 / 23287817
vascular5 / 5178096
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 221942_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts29.4
Adipocyte26.15
AdrenalCortex31.45
Adrenalgland28.15
Amygdala43.35
Appendix123.95
AtrioventricularNode27.85
BDCA4+_DentriticCells92.05
Bonemarrow36.3
BronchialEpithelialCells26.45
CD105+_Endothelial29.2
CD14+_Monocytes23.85
CD19+_BCells(neg._sel.)19.1
CD33+_Myeloid31.05
CD34+212.6
CD4+_Tcells18.75
CD56+_NKCells40.05
CD71+_EarlyErythroid24.95
CD8+_Tcells12.5
CardiacMyocytes41.55
Caudatenucleus41.6
Cerebellum28.8
CerebellumPeduncles36.1
CiliaryGanglion32.4
CingulateCortex65.05
Colorectaladenocarcinoma32.05
DorsalRootGanglion27.6
FetalThyroid38.9
Fetalbrain69.05
Fetalliver37.4
Fetallung46.25
GlobusPallidus35.45
Heart43.35
Hypothalamus40.2
Kidney29.9
Leukemia_chronicMyelogenousK-56229.3
Leukemia_promyelocytic-HL-6024.85
Leukemialymphoblastic(MOLT-4)28.05
Liver48.65
Lung41.25
Lymphnode35.55
Lymphoma_burkitts(Daudi)37.6
Lymphoma_burkitts(Raji)51.25
MedullaOblongata92.55
OccipitalLobe42.4
OlfactoryBulb32.25
Ovary24.6
Pancreas23.45
PancreaticIslet39.95
ParietalLobe54.15
Pituitary66.65
Placenta35.95
Pons56.75
PrefrontalCortex73.2
Prostate197.35
Salivarygland29.6
SkeletalMuscle62.7
Skin35.7
SmoothMuscle30.05
Spinalcord39.3
SubthalamicNucleus43.9
SuperiorCervicalGanglion105.5
TemporalLobe55.3
Testis31.65
TestisGermCell27.45
TestisIntersitial17.95
TestisLeydigCell32.8
TestisSeminiferousTubule24
Thalamus40.55
Thymus29.85
Thyroid41.95
Tongue38.75
Tonsil37.45
Trachea37.75
TrigeminalGanglion36.65
Uterus78.6
UterusCorpus51.45
WholeBlood34.6
Wholebrain38.4
colon78.95
pineal_day48.88
pineal_night43.8
retina94.525
small_intestine51.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P69573
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.14 ± 0.42
Basal Forebrain8.97 ± 0.58
Basal Part of Pons8.25 ± 0.24
Cerebellar Cortex8.19 ± 0.29
Cerebellar Nuclei9.1 ± 0.37
Claustrum7.62 ± 0.55
Epithalamus8.41 ± 1.26
Frontal Lobe8.84 ± 0.43
Globus Pallidus8.54 ± 0.61
Hypothalamus8.81 ± 0.57
Insula8.93 ± 0.33
Limbic Lobe8.71 ± 0.57
Mesencephalon8.81 ± 0.73
Myelencephalon8.81 ± 0.6
Occipital Lobe8.58 ± 0.8
Parietal Lobe8.74 ± 0.51
Pontine Tegmentum9.1 ± 0.54
Striatum10.21 ± 0.38
Subthalamus8.37 ± 0.11
Temporal Lobe9.08 ± 0.45
Thalamus9.31 ± 0.5
White Matter7.33 ± 0.29
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Gucy1a3CBCerebellum8.83
9.93
Gucy1a3CTXCerebral cortex17.16
13.4
Gucy1a3HIPHippocampal region11.24
13.36
Gucy1a3HPFHippocampal formation9.38
9.83
Gucy1a3HYHypothalamus7.22
6.32
Gucy1a3LSXLateral septal complex4.51
3.15
Gucy1a3MBMidbrain3.91
4.13
Gucy1a3MYMedulla7.13
6.76
Gucy1a3OLFOlfactory bulb39.57
26.63
Gucy1a3PPons8.57
9.56
Gucy1a3PALPallidum11.34
10.43
Gucy1a3RHPRetrohippocampal region6.8
5.29
Gucy1a3sAMYStriatum-like amygdalar nuclei8.21
5.84
Gucy1a3STRStriatum24.9
20.64
Gucy1a3STRdStriatum dorsal region16.39
11.95
Gucy1a3STRvStriatum ventral region74.64
63.65
Gucy1a3THThalamus11.09
10.49
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
GCYA3_HUMAN_172 11 172 182 QSSHCQEAGKR PRIDE
GCYA3_HUMAN_389 21 389 409 LEDFTGRGLYLSDIPIHNALR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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