AutismKB 2.0

Annotation Detail for ANAPC2


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Basic Information Top
Gene Symbol:ANAPC2 ( APC2,RP11-350O14.5 )
Gene Full Name: anaphase promoting complex subunit 2
Band: 9q34.3
Quick LinksEntrez ID:29882; OMIM: 606946; Uniprot ID:ANC2_HUMAN; ENSEMBL ID: ENSG00000176248; HGNC ID: 19989
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst7 / 62319112
fetus13 / 56401223
neonate0 / 310970 
infant0 / 236200 
juvenile3 / 5555653
adult73 / 193912137
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor2 / 9417821
cervical tumor3 / 3436687
chondrosarcoma2 / 8282324
colorectal tumor8 / 11424670
esophageal tumor0 / 172900 
gastrointestinal tumor7 / 11936958
germ cell tumor7 / 26384526
glioma4 / 10688337
head and neck tumor2 / 13630214
kidney tumor0 / 689590 
leukemia10 / 95842104
liver tumor3 / 9635931
lung tumor14 / 103127135
lymphoma30 / 71755418
non-neoplasia1 / 9725010
normal103 / 336030730
ovarian tumor2 / 7668226
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer4 / 10268038
retinoblastoma1 / 4635621
skin tumor10 / 12494980
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites2 / 4001549
bladder0 / 297570 
blood13 / 123478105
bone2 / 7165527
bone marrow1 / 4880120
brain20 / 110098918
cervix3 / 4817162
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue15 / 21572269
esophagus0 / 202090 
eye10 / 21105447
heart0 / 896260 
intestine13 / 23447255
kidney2 / 2117779
larynx0 / 241450 
liver3 / 20774314
lung24 / 33697471
lymph30 / 44270677
lymph node1 / 9161010
mammary gland3 / 15327119
mouth0 / 670520 
muscle1 / 1077159
nerve2 / 15768126
ovary2 / 10205119
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta15 / 28082553
prostate5 / 18934526
salivary gland2 / 2015599
skin11 / 21057452
spleen0 / 539520 
stomach4 / 9661941
testis2 / 3304426
thymus1 / 8113112
thyroid0 / 474730 
tonsil1 / 1699958
trachea0 / 524130 
umbilical cord0 / 136800 
uterus8 / 23287834
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218555_at
Cell line Expression level Expression bar
721_B_lymphoblasts31.65
Adipocyte5.85
AdrenalCortex7.45
Adrenalgland8.1
Amygdala33.35
Appendix6.15
AtrioventricularNode4.65
BDCA4+_DentriticCells46.15
Bonemarrow7.85
BronchialEpithelialCells7.35
CD105+_Endothelial38.3
CD14+_Monocytes27.95
CD19+_BCells(neg._sel.)19.35
CD33+_Myeloid35.1
CD34+48.1
CD4+_Tcells57
CD56+_NKCells32.35
CD71+_EarlyErythroid9
CD8+_Tcells55.2
CardiacMyocytes11.15
Caudatenucleus9.65
Cerebellum8.4
CerebellumPeduncles10.25
CiliaryGanglion4.35
CingulateCortex19.2
Colorectaladenocarcinoma12.15
DorsalRootGanglion4.15
FetalThyroid12.65
Fetalbrain10.45
Fetalliver5.9
Fetallung11.05
GlobusPallidus5.15
Heart12.35
Hypothalamus11.4
Kidney7.55
Leukemia_chronicMyelogenousK-56214.75
Leukemia_promyelocytic-HL-6013.35
Leukemialymphoblastic(MOLT-4)17.3
Liver17
Lung32.5
Lymphnode17.15
Lymphoma_burkitts(Daudi)18.05
Lymphoma_burkitts(Raji)116.65
MedullaOblongata7.95
OccipitalLobe7.4
OlfactoryBulb7.65
Ovary4.8
Pancreas4.6
PancreaticIslet13.55
ParietalLobe7.7
Pituitary9
Placenta6.75
Pons6.2
PrefrontalCortex28.9
Prostate34.8
Salivarygland6.65
SkeletalMuscle6.6
Skin5.7
SmoothMuscle7.6
Spinalcord15.4
SubthalamicNucleus5.75
SuperiorCervicalGanglion8.6
TemporalLobe6.2
Testis57.5
TestisGermCell13.1
TestisIntersitial11.55
TestisLeydigCell14.8
TestisSeminiferousTubule13.5
Thalamus10.6
Thymus21.85
Thyroid52.25
Tongue6.1
Tonsil8.15
Trachea6.05
TrigeminalGanglion5.75
Uterus14.9
UterusCorpus5.5
WholeBlood9.1
Wholebrain14.95
colon9.05
pineal_day26.98
pineal_night19.88
retina18.5
small_intestine6.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P253068
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.91 ± 0.8
Basal Forebrain2.5 ± 0.51
Basal Part of Pons2.7 ± 0.67
Cerebellar Cortex3.23 ± 0.45
Cerebellar Nuclei2.69 ± 0.51
Claustrum2.77 ± 0.77
Epithalamus2.59 ± 0.58
Frontal Lobe3.02 ± 0.59
Globus Pallidus2.44 ± 0.59
Hypothalamus2.83 ± 0.52
Insula2.89 ± 0.55
Limbic Lobe2.71 ± 0.72
Mesencephalon2.85 ± 0.7
Myelencephalon2.82 ± 0.65
Occipital Lobe2.46 ± 0.6
Parietal Lobe2.81 ± 0.7
Pontine Tegmentum2.82 ± 0.59
Striatum2.29 ± 0.56
Subthalamus2.76 ± 0.49
Temporal Lobe2.91 ± 0.55
Thalamus2.72 ± 0.66
White Matter3.22 ± 0.48
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Anapc2CBCerebellum38.09
46.93
Anapc2CTXCerebral cortex86.33
73.8
Anapc2HIPHippocampal region42.25
60.01
Anapc2HPFHippocampal formation51.93
59.33
Anapc2HYHypothalamus64.59
59.59
Anapc2LSXLateral septal complex37.74
32.39
Anapc2MBMidbrain73.17
76.12
Anapc2MYMedulla82.4
100
Anapc2OLFOlfactory bulb77.97
70.28
Anapc2PPons68.54
84.21
Anapc2PALPallidum62.37
67.43
Anapc2RHPRetrohippocampal region68.3
59.82
Anapc2sAMYStriatum-like amygdalar nuclei60.68
51.27
Anapc2STRStriatum37.43
30.79
Anapc2STRdStriatum dorsal region31.62
26.15
Anapc2STRvStriatum ventral region44.99
34.23
Anapc2THThalamus87.83
85.92
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
ANC2_HUMAN_235 15 235 249 QALEQFHQLSQVLHR PRIDE
ANC2_HUMAN_495 17 495 511 RRSSDIISLLVSIYGSK PRIDE
PAp00497869 15 256 270 VSAEAVTTTLHQVTR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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