AutismKB 2.0

Annotation Detail for GNL2


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Basic Information Top
Gene Symbol:GNL2 ( FLJ40906,HUMAUANTIG,NGP1,Ngp-1 )
Gene Full Name: guanine nucleotide binding protein-like 2 (nucleolar)
Band: 1p34.3
Quick LinksEntrez ID:29889; OMIM: 609365; Uniprot ID:NOG2_HUMAN; ENSEMBL ID: ENSG00000134697; HGNC ID: 29925
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst11 / 62319176
fetus41 / 56401272
neonate9 / 31097289
infant1 / 2362042
juvenile24 / 55556431
adult200 / 1939121103
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor15 / 94178159
cervical tumor0 / 343660 
chondrosarcoma10 / 82823120
colorectal tumor16 / 114246140
esophageal tumor5 / 17290289
gastrointestinal tumor13 / 119369108
germ cell tumor75 / 263845284
glioma6 / 10688356
head and neck tumor11 / 13630280
kidney tumor6 / 6895987
leukemia12 / 95842125
liver tumor6 / 9635962
lung tumor13 / 103127126
lymphoma7 / 7175597
non-neoplasia7 / 9725071
normal289 / 336030786
ovarian tumor7 / 7668291
pancreatic tumor6 / 10461657
primitive neuroectodermal tumor of the CNS27 / 125680214
prostate cancer11 / 102680107
retinoblastoma3 / 4635664
skin tumor19 / 124949152
soft tissue/muscle tissue tumor14 / 125191111
uterine tumor11 / 90257121
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue4 / 13106305
adrenal gland2 / 3319760
ascites7 / 40015174
bladder4 / 29757134
blood16 / 123478129
bone9 / 71655125
bone marrow10 / 48801204
brain90 / 110098981
cervix2 / 4817141
connective tissue14 / 14925593
ear0 / 162120 
embryonic tissue22 / 215722101
esophagus5 / 20209247
eye15 / 21105471
heart6 / 8962666
intestine23 / 23447298
kidney27 / 211777127
larynx1 / 2414541
liver20 / 20774396
lung40 / 336974118
lymph2 / 4427045
lymph node4 / 9161043
mammary gland17 / 153271110
mouth5 / 6705274
muscle20 / 107715185
nerve1 / 1576863
ovary12 / 102051117
pancreas8 / 21481237
parathyroid1 / 2053948
pharynx5 / 41328120
pituitary gland0 / 165850 
placenta13 / 28082546
prostate14 / 18934573
salivary gland0 / 201550 
skin31 / 210574147
spleen6 / 53952111
stomach8 / 9661982
testis63 / 330442190
thymus8 / 8113198
thyroid5 / 47473105
tonsil4 / 16999235
trachea3 / 5241357
umbilical cord1 / 1368073
uterus33 / 232878141
vascular19 / 51780366
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201948_at
Cell line Expression level Expression bar
721_B_lymphoblasts311.65
Adipocyte16.35
AdrenalCortex19.1
Adrenalgland13.2
Amygdala17.65
Appendix17.15
AtrioventricularNode14.6
BDCA4+_DentriticCells182.4
Bonemarrow15.8
BronchialEpithelialCells48.9
CD105+_Endothelial184.2
CD14+_Monocytes84.95
CD19+_BCells(neg._sel.)28.4
CD33+_Myeloid60.3
CD34+176.5
CD4+_Tcells47.8
CD56+_NKCells130.9
CD71+_EarlyErythroid19.95
CD8+_Tcells58.9
CardiacMyocytes37.75
Caudatenucleus13.95
Cerebellum12.65
CerebellumPeduncles18.65
CiliaryGanglion18.45
CingulateCortex15.85
Colorectaladenocarcinoma32.05
DorsalRootGanglion14.7
FetalThyroid17.55
Fetalbrain23.4
Fetalliver15.5
Fetallung22.6
GlobusPallidus12.1
Heart23.55
Hypothalamus22.15
Kidney13.55
Leukemia_chronicMyelogenousK-562119.85
Leukemia_promyelocytic-HL-6030.35
Leukemialymphoblastic(MOLT-4)27.95
Liver22.6
Lung16.25
Lymphnode14.25
Lymphoma_burkitts(Daudi)46.5
Lymphoma_burkitts(Raji)32.55
MedullaOblongata13.25
OccipitalLobe14.7
OlfactoryBulb13.1
Ovary10.95
Pancreas15.45
PancreaticIslet31.25
ParietalLobe20.9
Pituitary19.95
Placenta14.05
Pons15.3
PrefrontalCortex20.85
Prostate17.9
Salivarygland13.45
SkeletalMuscle21.15
Skin13.45
SmoothMuscle25.25
Spinalcord16.85
SubthalamicNucleus15.4
SuperiorCervicalGanglion21.55
TemporalLobe15.2
Testis14.45
TestisGermCell51.7
TestisIntersitial24.5
TestisLeydigCell17.4
TestisSeminiferousTubule15.3
Thalamus17.55
Thymus10.15
Thyroid20.25
Tongue17.1
Tonsil18.25
Trachea12.75
TrigeminalGanglion17.45
Uterus21.95
UterusCorpus14.85
WholeBlood18.9
Wholebrain10.1
colon15.85
pineal_day21.82
pineal_night20.62
retina19.625
small_intestine14.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_11631_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.43 ± 0.61
Basal Forebrain4.59 ± 0.52
Basal Part of Pons4.86 ± 0.44
Cerebellar Cortex4.78 ± 0.44
Cerebellar Nuclei4.65 ± 0.42
Claustrum4.37 ± 0.69
Epithalamus5.05 ± 0.54
Frontal Lobe4.73 ± 0.52
Globus Pallidus4.52 ± 0.58
Hypothalamus4.8 ± 0.5
Insula4.79 ± 0.2
Limbic Lobe4.6 ± 0.55
Mesencephalon4.73 ± 0.51
Myelencephalon4.65 ± 0.52
Occipital Lobe4.49 ± 0.53
Parietal Lobe4.75 ± 0.41
Pontine Tegmentum4.64 ± 0.49
Striatum4.32 ± 0.48
Subthalamus4.76 ± 0.32
Temporal Lobe4.77 ± 0.41
Thalamus4.85 ± 0.47
White Matter5.44 ± 0.43
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Gnl2CBCerebellum27.87
44.56
Gnl2CTXCerebral cortex100
100
Gnl2HIPHippocampal region82.23
100
Gnl2HPFHippocampal formation87.14
100
Gnl2HYHypothalamus53.57
47.48
Gnl2LSXLateral septal complex68.98
55.73
Gnl2MBMidbrain55.99
57.76
Gnl2MYMedulla36.3
45.07
Gnl2OLFOlfactory bulb77.46
75.21
Gnl2PPons40.52
47.66
Gnl2PALPallidum40.28
36.46
Gnl2RHPRetrohippocampal region98.51
95.78
Gnl2sAMYStriatum-like amygdalar nuclei44.93
36.61
Gnl2STRStriatum49.97
39.09
Gnl2STRdStriatum dorsal region42.9
33.04
Gnl2STRvStriatum ventral region66.05
49.71
Gnl2THThalamus66.69
61.25
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
NOG2_HUMAN_1 9 1 9 MVKPKYKGR PRIDE
NOG2_HUMAN_2 8 2 9 VKPKYKGR PRIDE
NOG2_HUMAN_688 10 688 697 QQRPKKVGVR PRIDE
PAp00070103 13 412 424 IDSWENAEDFLEK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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