AutismKB 2.0

Annotation Detail for SEC61A1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SEC61A1 ( HSEC61,SEC61,SEC61A )
Gene Full Name: Sec61 alpha 1 subunit (S. cerevisiae)
Band: 3q21.3
Quick LinksEntrez ID:29927; OMIM: 609213; Uniprot ID:S61A1_HUMAN; ENSEMBL ID: ENSG00000058262; HGNC ID: 18276
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body36 / 70761508
blastocyst14 / 62319224
fetus113 / 564012200
neonate16 / 31097514
infant7 / 23620296
juvenile38 / 55556683
adult778 / 1939121401
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor4 / 12794312
bladder carcinoma1 / 1747557
breast (mammary gland) tumor29 / 94178307
cervical tumor7 / 34366203
chondrosarcoma44 / 82823531
colorectal tumor28 / 114246245
esophageal tumor4 / 17290231
gastrointestinal tumor152 / 1193691273
germ cell tumor260 / 263845985
glioma38 / 106883355
head and neck tumor124 / 136302909
kidney tumor19 / 68959275
leukemia29 / 95842302
liver tumor38 / 96359394
lung tumor18 / 103127174
lymphoma8 / 71755111
non-neoplasia46 / 97250473
normal938 / 3360307279
ovarian tumor19 / 76682247
pancreatic tumor28 / 104616267
primitive neuroectodermal tumor of the CNS36 / 125680286
prostate cancer41 / 102680399
retinoblastoma3 / 4635664
skin tumor52 / 124949416
soft tissue/muscle tissue tumor21 / 125191167
uterine tumor28 / 90257310
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland12 / 33197361
ascites121 / 400153023
bladder3 / 29757100
blood19 / 123478153
bone33 / 71655460
bone marrow24 / 48801491
brain321 / 1100989291
cervix7 / 48171145
connective tissue75 / 149255502
ear0 / 162120 
embryonic tissue70 / 215722324
esophagus4 / 20209197
eye59 / 211054279
heart7 / 8962678
intestine73 / 234472311
kidney80 / 211777377
larynx4 / 24145165
liver48 / 207743231
lung223 / 336974661
lymph4 / 4427090
lymph node23 / 91610251
mammary gland42 / 153271274
mouth101 / 670521506
muscle2 / 10771518
nerve8 / 15768507
ovary30 / 102051293
pancreas30 / 214812139
parathyroid3 / 20539146
pharynx2 / 4132848
pituitary gland2 / 16585120
placenta95 / 280825338
prostate58 / 189345306
salivary gland11 / 20155545
skin86 / 210574408
spleen8 / 53952148
stomach26 / 96619269
testis247 / 330442747
thymus37 / 81131456
thyroid14 / 47473294
tonsil0 / 169990 
trachea67 / 524131278
umbilical cord8 / 13680584
uterus69 / 232878296
vascular27 / 51780521
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 217716_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts233.95
Adipocyte130.05
AdrenalCortex78.05
Adrenalgland90.75
Amygdala13.65
Appendix7.7
AtrioventricularNode6.35
BDCA4+_DentriticCells633.2
Bonemarrow28.75
BronchialEpithelialCells312.4
CD105+_Endothelial86.1
CD14+_Monocytes156.5
CD19+_BCells(neg._sel.)69.85
CD33+_Myeloid121.85
CD34+180.2
CD4+_Tcells81.1
CD56+_NKCells174.7
CD71+_EarlyErythroid48.05
CD8+_Tcells98.95
CardiacMyocytes354.6
Caudatenucleus11.7
Cerebellum9.45
CerebellumPeduncles14.7
CiliaryGanglion4.5
CingulateCortex9.95
Colorectaladenocarcinoma255.15
DorsalRootGanglion6.2
FetalThyroid112.65
Fetalbrain13.75
Fetalliver17.3
Fetallung69
GlobusPallidus6.05
Heart53.35
Hypothalamus23.45
Kidney25.5
Leukemia_chronicMyelogenousK-56217.9
Leukemia_promyelocytic-HL-6012.35
Leukemialymphoblastic(MOLT-4)45.9
Liver488.85
Lung429.9
Lymphnode46.45
Lymphoma_burkitts(Daudi)15.45
Lymphoma_burkitts(Raji)63.1
MedullaOblongata8.65
OccipitalLobe7.65
OlfactoryBulb9.05
Ovary12.55
Pancreas209.85
PancreaticIslet95.8
ParietalLobe11.35
Pituitary89.25
Placenta221.1
Pons6.25
PrefrontalCortex17.5
Prostate590.35
Salivarygland6.85
SkeletalMuscle10.5
Skin6.2
SmoothMuscle779.6
Spinalcord17.75
SubthalamicNucleus5.7
SuperiorCervicalGanglion7.45
TemporalLobe7.6
Testis19.5
TestisGermCell44.4
TestisIntersitial9.3
TestisLeydigCell9.65
TestisSeminiferousTubule9.4
Thalamus9.95
Thymus65.2
Thyroid171.75
Tongue13.05
Tonsil15
Trachea70.5
TrigeminalGanglion6.3
Uterus142
UterusCorpus26.7
WholeBlood45.4
Wholebrain29.8
colon47.55
pineal_day32.6
pineal_night34.06
retina32.7
small_intestine58.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P122891
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.07 ± 0.78
Basal Forebrain4.15 ± 0.28
Basal Part of Pons4.11 ± 0.53
Cerebellar Cortex4.64 ± 0.35
Cerebellar Nuclei4.09 ± 0.51
Claustrum3.66 ± 1.01
Epithalamus5.33 ± 0.46
Frontal Lobe4.12 ± 0.72
Globus Pallidus4.37 ± 0.52
Hypothalamus4.24 ± 0.72
Insula4.47 ± 0.5
Limbic Lobe3.93 ± 0.61
Mesencephalon4.34 ± 0.57
Myelencephalon4.18 ± 0.65
Occipital Lobe4.01 ± 0.56
Parietal Lobe4.18 ± 0.55
Pontine Tegmentum4.12 ± 0.72
Striatum4.12 ± 0.6
Subthalamus4.21 ± 0.49
Temporal Lobe4.18 ± 0.5
Thalamus4.13 ± 0.48
White Matter4.51 ± 0.13
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Sec61a1CBCerebellum38.72
100
Sec61a1CTXCerebral cortex100
100
Sec61a1HIPHippocampal region98.71
100
Sec61a1HPFHippocampal formation85.11
100
Sec61a1HYHypothalamus23.41
24.05
Sec61a1LSXLateral septal complex32.79
29.42
Sec61a1MBMidbrain19
22.1
Sec61a1MYMedulla13.69
16.06
Sec61a1OLFOlfactory bulb50.6
52.13
Sec61a1PPons12.25
14.84
Sec61a1PALPallidum18.78
19.52
Sec61a1RHPRetrohippocampal region47.11
52.76
Sec61a1sAMYStriatum-like amygdalar nuclei38.87
35.42
Sec61a1STRStriatum25.36
22.6
Sec61a1STRdStriatum dorsal region21.71
19.87
Sec61a1STRvStriatum ventral region28.22
22.62
Sec61a1THThalamus26.57
24.86
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00002480 20 5 24 FLEVIKPFCVILPEIQKPER Peptide Atlas
S61A1_HUMAN_1 11 1 11 AIKFLEVIKPF PRIDE
S61A1_HUMAN_395 7 395 401 EQQMVMR PRIDE
S61A1_HUMAN_4 20 4 23 FLEVIKPFCVILPEIQKPER PRIDE
S61A1_HUMAN_405 10 405 414 ETSMVHELNR PRIDE
S61A1_HUMAN_73 25 73 97 GTLMELGISPIVTSGLIMQLLAGAK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved