AutismKB 2.0

Annotation Detail for ANAPC4


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Basic Information Top
Gene Symbol:ANAPC4 ( APC4 )
Gene Full Name: anaphase promoting complex subunit 4
Band: 4p15.2
Quick LinksEntrez ID:29945; OMIM: 606947; Uniprot ID:APC4_HUMAN; ENSEMBL ID: ENSG00000053900; HGNC ID: 19990
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst0 / 623190 
fetus15 / 56401226
neonate0 / 310970 
infant2 / 2362084
juvenile1 / 5555617
adult79 / 193912140
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor5 / 9417853
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor6 / 26384522
glioma2 / 10688318
head and neck tumor3 / 13630222
kidney tumor3 / 6895943
leukemia1 / 9584210
liver tumor4 / 9635941
lung tumor1 / 1031279
lymphoma2 / 7175527
non-neoplasia9 / 9725092
normal94 / 336030727
ovarian tumor3 / 7668239
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor14 / 90257155
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland1 / 3319730
ascites0 / 400150 
bladder1 / 2975733
blood1 / 1234788
bone4 / 7165555
bone marrow0 / 488010 
brain29 / 110098926
cervix0 / 481710 
connective tissue6 / 14925540
ear1 / 1621261
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye3 / 21105414
heart8 / 8962689
intestine7 / 23447229
kidney9 / 21177742
larynx1 / 2414541
liver6 / 20774328
lung5 / 33697414
lymph2 / 4427045
lymph node4 / 9161043
mammary gland10 / 15327165
mouth0 / 670520 
muscle0 / 1077150 
nerve1 / 1576863
ovary3 / 10205129
pancreas8 / 21481237
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland1 / 1658560
placenta18 / 28082564
prostate3 / 18934515
salivary gland0 / 201550 
skin2 / 2105749
spleen1 / 5395218
stomach3 / 9661931
testis4 / 33044212
thymus3 / 8113136
thyroid2 / 4747342
tonsil0 / 169990 
trachea5 / 5241395
umbilical cord0 / 136800 
uterus18 / 23287877
vascular1 / 5178019
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_5522_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.61 ± 0.28
Basal Forebrain7.64 ± 0.18
Basal Part of Pons7.69 ± 0.22
Cerebellar Cortex7.83 ± 0.16
Cerebellar Nuclei7.51 ± 0.25
Claustrum7.31 ± 0.42
Epithalamus7.97 ± 0.28
Frontal Lobe7.64 ± 0.27
Globus Pallidus7.62 ± 0.13
Hypothalamus7.62 ± 0.19
Insula7.74 ± 0.17
Limbic Lobe7.63 ± 0.24
Mesencephalon7.6 ± 0.24
Myelencephalon7.63 ± 0.28
Occipital Lobe7.86 ± 0.32
Parietal Lobe7.65 ± 0.25
Pontine Tegmentum7.67 ± 0.27
Striatum7.37 ± 0.27
Subthalamus7.95 ± 0.09
Temporal Lobe7.79 ± 0.22
Thalamus7.55 ± 0.27
White Matter8.21 ± 0.09
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Anapc4CBCerebellum7.07
7.73
Anapc4CTXCerebral cortex25.68
19.03
Anapc4HIPHippocampal region45.67
57.66
Anapc4HPFHippocampal formation45.5
49.52
Anapc4HYHypothalamus37.28
32.18
Anapc4LSXLateral septal complex16.84
12.31
Anapc4MBMidbrain18.68
18.9
Anapc4MYMedulla10.65
16.69
Anapc4OLFOlfactory bulb23.15
19.76
Anapc4PPons20.65
27.15
Anapc4PALPallidum25.39
24.59
Anapc4RHPRetrohippocampal region45.9
36.47
Anapc4sAMYStriatum-like amygdalar nuclei42.75
33.01
Anapc4STRStriatum15.71
11.91
Anapc4STRdStriatum dorsal region8.64
6.31
Anapc4STRvStriatum ventral region21.9
16.3
Anapc4THThalamus21.3
16.89
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00069824 16 604 619 HTDISQSVSNGLIAIK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018