AutismKB 2.0

Annotation Detail for PRICKLE4


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Basic Information Top
Gene Symbol:PRICKLE4 ( C6orf49,MGC120398,OBTP,OEBT,TOMM6 )
Gene Full Name: prickle homolog 4 (Drosophila)
Band: 6p21.1
Quick LinksEntrez ID:29964; OMIM: 611389; Uniprot ID:PRIC4_HUMAN; ENSEMBL ID: ENSG00000124593; HGNC ID: 16805
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst2 / 6231932
fetus1 / 5640121
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult12 / 19391216
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor1 / 2638453
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia2 / 9584220
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal38 / 336030711
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood2 / 12347816
bone0 / 716550 
bone marrow0 / 488010 
brain9 / 11009898
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue4 / 21572218
esophagus0 / 202090 
eye1 / 2110544
heart3 / 8962633
intestine4 / 23447217
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung0 / 3369740 
lymph0 / 442700 
lymph node1 / 9161010
mammary gland1 / 1532716
mouth0 / 670520 
muscle3 / 10771527
nerve0 / 157680 
ovary0 / 1020510 
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta1 / 2808253
prostate3 / 18934515
salivary gland0 / 201550 
skin0 / 2105740 
spleen8 / 53952148
stomach1 / 9661910
testis4 / 33044212
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218233_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts1073.2
Adipocyte382.95
AdrenalCortex349.2
Adrenalgland483.8
Amygdala215.25
Appendix146.5
AtrioventricularNode99.05
BDCA4+_DentriticCells835.25
Bonemarrow340.05
BronchialEpithelialCells933.55
CD105+_Endothelial799.45
CD14+_Monocytes806
CD19+_BCells(neg._sel.)1004.7
CD33+_Myeloid616.45
CD34+815.1
CD4+_Tcells545.4
CD56+_NKCells712
CD71+_EarlyErythroid417.05
CD8+_Tcells545.9
CardiacMyocytes249.45
Caudatenucleus195.35
Cerebellum125.6
CerebellumPeduncles161.2
CiliaryGanglion56.7
CingulateCortex232.5
Colorectaladenocarcinoma127.55
DorsalRootGanglion123.8
FetalThyroid437.7
Fetalbrain203.65
Fetalliver281
Fetallung391.85
GlobusPallidus118.05
Heart271.35
Hypothalamus397.3
Kidney324.7
Leukemia_chronicMyelogenousK-5621402.65
Leukemia_promyelocytic-HL-60979.35
Leukemialymphoblastic(MOLT-4)665.6
Liver202.75
Lung411.85
Lymphnode366.1
Lymphoma_burkitts(Daudi)573.25
Lymphoma_burkitts(Raji)475.8
MedullaOblongata256.05
OccipitalLobe246.6
OlfactoryBulb283.2
Ovary199.6
Pancreas284.25
PancreaticIslet533.75
ParietalLobe211.3
Pituitary442.45
Placenta290.65
Pons130.65
PrefrontalCortex375.1
Prostate357.25
Salivarygland333.15
SkeletalMuscle151.55
Skin160.3
SmoothMuscle449.65
Spinalcord327.6
SubthalamicNucleus184.7
SuperiorCervicalGanglion104.1
TemporalLobe223.1
Testis455.95
TestisGermCell453.65
TestisIntersitial294.95
TestisLeydigCell231.35
TestisSeminiferousTubule285.6
Thalamus247.2
Thymus384.85
Thyroid358.95
Tongue228.3
Tonsil444.15
Trachea234.35
TrigeminalGanglion149.9
Uterus231.05
UterusCorpus287.9
WholeBlood487.95
Wholebrain323.25
colon322.5
pineal_day499.08
pineal_night419.8
retina429.425
small_intestine449.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_6641_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.76 ± 0.47
Basal Forebrain4.93 ± 0.36
Basal Part of Pons4.58 ± 0.42
Cerebellar Cortex4.33 ± 0.33
Cerebellar Nuclei4.67 ± 0.25
Claustrum4.72 ± 0.54
Epithalamus4.46 ± 0.27
Frontal Lobe4.53 ± 0.43
Globus Pallidus5.39 ± 0.27
Hypothalamus4.56 ± 0.29
Insula4.43 ± 0.58
Limbic Lobe4.82 ± 0.49
Mesencephalon4.61 ± 0.48
Myelencephalon4.68 ± 0.47
Occipital Lobe4.92 ± 0.42
Parietal Lobe4.75 ± 0.42
Pontine Tegmentum4.66 ± 0.4
Striatum5.07 ± 0.36
Subthalamus4.66 ± 0.61
Temporal Lobe4.61 ± 0.49
Thalamus4.62 ± 0.41
White Matter5.09 ± 0.16
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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