AutismKB 2.0

Annotation Detail for TNPO2


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Basic Information Top
Gene Symbol:TNPO2 ( FLJ12155,IPO3,KPNB2B,TRN2 )
Gene Full Name: transportin 2
Band: 19p13.13
Quick LinksEntrez ID:30000; OMIM: 603002; Uniprot ID:TNPO2_HUMAN; ENSEMBL ID: ENSG00000105576; HGNC ID: 19998
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body8 / 70761113
blastocyst6 / 6231996
fetus54 / 56401295
neonate1 / 3109732
infant1 / 2362042
juvenile0 / 555560 
adult105 / 193912154
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor9 / 9417895
cervical tumor0 / 343660 
chondrosarcoma5 / 8282360
colorectal tumor8 / 11424670
esophageal tumor2 / 17290115
gastrointestinal tumor8 / 11936967
germ cell tumor30 / 263845113
glioma9 / 10688384
head and neck tumor7 / 13630251
kidney tumor4 / 6895958
leukemia6 / 9584262
liver tumor2 / 9635920
lung tumor4 / 10312738
lymphoma3 / 7175541
non-neoplasia2 / 9725020
normal211 / 336030762
ovarian tumor3 / 7668239
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS11 / 12568087
prostate cancer1 / 1026809
retinoblastoma2 / 4635643
skin tumor11 / 12494988
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites1 / 4001524
bladder0 / 297570 
blood5 / 12347840
bone5 / 7165569
bone marrow13 / 48801266
brain115 / 1100989104
cervix0 / 481710 
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue19 / 21572288
esophagus2 / 2020998
eye7 / 21105433
heart3 / 8962633
intestine14 / 23447259
kidney10 / 21177747
larynx1 / 2414541
liver4 / 20774319
lung15 / 33697444
lymph0 / 442700 
lymph node7 / 9161076
mammary gland12 / 15327178
mouth3 / 6705244
muscle12 / 107715111
nerve1 / 1576863
ovary8 / 10205178
pancreas7 / 21481232
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta10 / 28082535
prostate4 / 18934521
salivary gland1 / 2015549
skin14 / 21057466
spleen2 / 5395237
stomach4 / 9661941
testis24 / 33044272
thymus5 / 8113161
thyroid2 / 4747342
tonsil3 / 16999176
trachea1 / 5241319
umbilical cord2 / 13680146
uterus12 / 23287851
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 221507_at
Cell line Expression level Expression bar
721_B_lymphoblasts165.5
Adipocyte124.95
AdrenalCortex118.2
Adrenalgland114.1
Amygdala380.95
Appendix89.1
AtrioventricularNode73.6
BDCA4+_DentriticCells59.65
Bonemarrow119.85
BronchialEpithelialCells90.3
CD105+_Endothelial122.4
CD14+_Monocytes30.05
CD19+_BCells(neg._sel.)50.8
CD33+_Myeloid54.15
CD34+127.75
CD4+_Tcells87.75
CD56+_NKCells48.9
CD71+_EarlyErythroid87.7
CD8+_Tcells86.75
CardiacMyocytes90.4
Caudatenucleus175.75
Cerebellum273.6
CerebellumPeduncles309.15
CiliaryGanglion54.35
CingulateCortex300.45
Colorectaladenocarcinoma113.15
DorsalRootGanglion38.9
FetalThyroid107.15
Fetalbrain375.05
Fetalliver44.45
Fetallung109.45
GlobusPallidus189.85
Heart135.95
Hypothalamus229.6
Kidney107.75
Leukemia_chronicMyelogenousK-562157.75
Leukemia_promyelocytic-HL-6098.3
Leukemialymphoblastic(MOLT-4)195.9
Liver66.6
Lung79.25
Lymphnode134.65
Lymphoma_burkitts(Daudi)86.6
Lymphoma_burkitts(Raji)125.25
MedullaOblongata165.3
OccipitalLobe195.1
OlfactoryBulb110.8
Ovary81.7
Pancreas83.1
PancreaticIslet140.5
ParietalLobe228.65
Pituitary157.7
Placenta146
Pons192.95
PrefrontalCortex863.25
Prostate71
Salivarygland36.7
SkeletalMuscle131.35
Skin89.1
SmoothMuscle88.2
Spinalcord144.7
SubthalamicNucleus289.5
SuperiorCervicalGanglion60.75
TemporalLobe175.8
Testis184.8
TestisGermCell169.9
TestisIntersitial128.75
TestisLeydigCell132.75
TestisSeminiferousTubule171.55
Thalamus187.5
Thymus183.7
Thyroid98.2
Tongue95.65
Tonsil73.95
Trachea60.65
TrigeminalGanglion109
Uterus72.45
UterusCorpus92.1
WholeBlood42.1
Wholebrain216.8
colon31.05
pineal_day317.26
pineal_night295.12
retina207.3
small_intestine25.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P208582
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.2 ± 0.63
Basal Forebrain7.41 ± 0.32
Basal Part of Pons7.8 ± 0.32
Cerebellar Cortex7.43 ± 0.4
Cerebellar Nuclei7.07 ± 0.49
Claustrum7.24 ± 0.47
Epithalamus7.44 ± 0.33
Frontal Lobe7.49 ± 0.41
Globus Pallidus6.55 ± 0.25
Hypothalamus7.24 ± 0.3
Insula7.54 ± 0.33
Limbic Lobe7.41 ± 0.42
Mesencephalon7.27 ± 0.39
Myelencephalon7.39 ± 0.53
Occipital Lobe7.09 ± 0.52
Parietal Lobe7.44 ± 0.43
Pontine Tegmentum7.24 ± 0.36
Striatum7.1 ± 0.45
Subthalamus7.15 ± 0.47
Temporal Lobe7.6 ± 0.32
Thalamus7.47 ± 0.54
White Matter6.55 ± 0.31
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tnpo2CBCerebellum16.85
45.64
Tnpo2CTXCerebral cortex100
100
Tnpo2HIPHippocampal region67.55
100
Tnpo2HPFHippocampal formation65.96
96.01
Tnpo2HYHypothalamus23.98
22.8
Tnpo2LSXLateral septal complex3.57
2.61
Tnpo2MBMidbrain17.34
20.69
Tnpo2MYMedulla17.87
31.19
Tnpo2OLFOlfactory bulb69.16
75.73
Tnpo2PPons15.86
24.82
Tnpo2PALPallidum32.96
37.77
Tnpo2RHPRetrohippocampal region64.65
73.29
Tnpo2sAMYStriatum-like amygdalar nuclei37.58
33.75
Tnpo2STRStriatum30.23
25.37
Tnpo2STRdStriatum dorsal region28.38
23.83
Tnpo2STRvStriatum ventral region41.79
32.46
Tnpo2THThalamus44.9
45.29
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00024505 14 375 388 CSAAALDVLANVFR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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