AutismKB 2.0

Annotation Detail for HIST1H1C


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Basic Information Top
Gene Symbol:HIST1H1C ( H1.2,H1C,H1F2,MGC3992 )
Gene Full Name: histone cluster 1, H1c
Band: 6p22.2
Quick LinksEntrez ID:3006; OMIM: 142710; Uniprot ID:H12_HUMAN; ENSEMBL ID: ENSG00000187837; HGNC ID: 4716
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst1 / 6231916
fetus23 / 56401240
neonate0 / 310970 
infant1 / 2362042
juvenile2 / 5555635
adult81 / 193912141
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor1 / 3436629
chondrosarcoma5 / 8282360
colorectal tumor3 / 11424626
esophageal tumor2 / 17290115
gastrointestinal tumor8 / 11936967
germ cell tumor2 / 2638457
glioma17 / 106883159
head and neck tumor4 / 13630229
kidney tumor0 / 689590 
leukemia11 / 95842114
liver tumor2 / 9635920
lung tumor4 / 10312738
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal125 / 336030737
ovarian tumor4 / 7668252
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer10 / 10268097
retinoblastoma0 / 463560 
skin tumor4 / 12494932
soft tissue/muscle tissue tumor7 / 12519155
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites7 / 40015174
bladder0 / 297570 
blood2 / 12347816
bone2 / 7165527
bone marrow9 / 48801184
brain24 / 110098921
cervix2 / 4817141
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus2 / 2020998
eye5 / 21105423
heart5 / 8962655
intestine10 / 23447242
kidney7 / 21177733
larynx0 / 241450 
liver11 / 20774352
lung16 / 33697447
lymph0 / 442700 
lymph node5 / 9161054
mammary gland3 / 15327119
mouth2 / 6705229
muscle7 / 10771564
nerve3 / 15768190
ovary5 / 10205148
pancreas10 / 21481246
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta23 / 28082581
prostate16 / 18934584
salivary gland2 / 2015599
skin6 / 21057428
spleen1 / 5395218
stomach4 / 9661941
testis7 / 33044221
thymus0 / 811310 
thyroid0 / 474730 
tonsil1 / 1699958
trachea0 / 524130 
umbilical cord0 / 136800 
uterus9 / 23287838
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209398_at
Cell line Expression level Expression bar
721_B_lymphoblasts310.55
Adipocyte18.35
AdrenalCortex7.65
Adrenalgland6.15
Amygdala6.95
Appendix9.3
AtrioventricularNode5.6
BDCA4+_DentriticCells61.1
Bonemarrow28.25
BronchialEpithelialCells7.9
CD105+_Endothelial10.5
CD14+_Monocytes14.9
CD19+_BCells(neg._sel.)234.95
CD33+_Myeloid9.7
CD34+11.7
CD4+_Tcells9.95
CD56+_NKCells23.35
CD71+_EarlyErythroid130.65
CD8+_Tcells9.2
CardiacMyocytes10.8
Caudatenucleus8.05
Cerebellum5.8
CerebellumPeduncles8.8
CiliaryGanglion4.7
CingulateCortex6.75
Colorectaladenocarcinoma18.4
DorsalRootGanglion5.55
FetalThyroid85.05
Fetalbrain7.6
Fetalliver13.3
Fetallung24.25
GlobusPallidus4.6
Heart90.65
Hypothalamus7.8
Kidney7.35
Leukemia_chronicMyelogenousK-562592.55
Leukemia_promyelocytic-HL-608.1
Leukemialymphoblastic(MOLT-4)5.35
Liver22.55
Lung41.2
Lymphnode6.4
Lymphoma_burkitts(Daudi)11.3
Lymphoma_burkitts(Raji)9.8
MedullaOblongata6.7
OccipitalLobe6.15
OlfactoryBulb28.8
Ovary11.05
Pancreas7.7
PancreaticIslet14.5
ParietalLobe9.9
Pituitary9.35
Placenta133.05
Pons7.1
PrefrontalCortex8.05
Prostate108.1
Salivarygland6.3
SkeletalMuscle12.55
Skin7.5
SmoothMuscle9.35
Spinalcord9.5
SubthalamicNucleus7.6
SuperiorCervicalGanglion10.2
TemporalLobe6.75
Testis7.75
TestisGermCell6.85
TestisIntersitial6.3
TestisLeydigCell7.35
TestisSeminiferousTubule8.25
Thalamus6.95
Thymus36.95
Thyroid20.35
Tongue9.65
Tonsil7.75
Trachea6.95
TrigeminalGanglion9.45
Uterus7.6
UterusCorpus8.3
WholeBlood41.5
Wholebrain7
colon9.8
pineal_day145.9
pineal_night46.52
retina9.625
small_intestine7.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_8313_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.77 ± 0.21
Basal Forebrain9.76 ± 0.22
Basal Part of Pons9.15 ± 0.36
Cerebellar Cortex9.95 ± 0.26
Cerebellar Nuclei9.34 ± 0.45
Claustrum8.98 ± 0.35
Epithalamus9.8 ± 0.34
Frontal Lobe9.43 ± 0.37
Globus Pallidus9.75 ± 0.48
Hypothalamus9.52 ± 0.36
Insula9.48 ± 0.34
Limbic Lobe9.46 ± 0.28
Mesencephalon9.56 ± 0.39
Myelencephalon9.57 ± 0.35
Occipital Lobe9.83 ± 0.43
Parietal Lobe9.51 ± 0.29
Pontine Tegmentum9.65 ± 0.33
Striatum9.62 ± 0.42
Subthalamus9.18 ± 0.37
Temporal Lobe9.48 ± 0.3
Thalamus9.64 ± 0.36
White Matter9.29 ± 0.35
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Hist1h1cCBCerebellum15.29
19.2
Hist1h1cCTXCerebral cortex18.74
13.45
Hist1h1cHIPHippocampal region13.48
13.12
Hist1h1cHPFHippocampal formation14.54
12.81
Hist1h1cHYHypothalamus3.67
2.95
Hist1h1cLSXLateral septal complex3.61
2.8
Hist1h1cMBMidbrain5.24
6.13
Hist1h1cMYMedulla10.73
14.36
Hist1h1cOLFOlfactory bulb23.84
18.01
Hist1h1cPPons8.24
10.89
Hist1h1cPALPallidum6.09
4.89
Hist1h1cRHPRetrohippocampal region16.43
12.51
Hist1h1csAMYStriatum-like amygdalar nuclei7.98
5.94
Hist1h1cSTRStriatum21.88
15.36
Hist1h1cSTRdStriatum dorsal region29.96
21.41
Hist1h1cSTRvStriatum ventral region12.06
7.64
Hist1h1cTHThalamus9.41
8.69
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
H12_HUMAN_1 16 1 16 SETAPAAPAAAPPAEK PRIDE
H12_HUMAN_1 32 1 32 SETAPAAPAAAPPAEKAPVKKKAAKKAGGTPR PRIDE
H12_HUMAN_33 21 33 53 KASGPPVSELITKAVAASKER PRIDE
H12_HUMAN_34 20 34 53 ASGPPVSELITKAVAASKER PRIDE
PAp00000491 11 65 75 ALAAAGYDVEK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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