AutismKB 2.0

Annotation Detail for HIST1H2AE


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Basic Information Top
Gene Symbol:HIST1H2AE ( H2A.1,H2A.2,H2A/a,H2AFA,HIST1H2AB )
Gene Full Name: histone cluster 1, H2ae
Band: 6p22.2
Quick LinksEntrez ID:3012; OMIM: 602786; Uniprot ID:H2A1B_HUMAN; ENSEMBL ID: ENSG00000168274; HGNC ID: 4724
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus7 / 56401212
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult5 / 19391212
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor1 / 1142468
esophageal tumor1 / 1729057
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma1 / 1068839
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal19 / 33603075
ovarian tumor1 / 7668213
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow1 / 4880120
brain4 / 11009893
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus1 / 2020949
eye0 / 2110540 
heart0 / 896260 
intestine2 / 2344728
kidney4 / 21177718
larynx0 / 241450 
liver0 / 2077430 
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland1 / 1532716
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary1 / 1020519
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta2 / 2808257
prostate2 / 18934510
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach1 / 9661910
testis3 / 3304429
thymus2 / 8113124
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208569_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.1
Adipocyte4.75
AdrenalCortex5.1
Adrenalgland4.1
Amygdala4.95
Appendix4.75
AtrioventricularNode3.65
BDCA4+_DentriticCells5.35
Bonemarrow4.9
BronchialEpithelialCells4.7
CD105+_Endothelial4.75
CD14+_Monocytes6.1
CD19+_BCells(neg._sel.)6.35
CD33+_Myeloid6.15
CD34+6.1
CD4+_Tcells5.25
CD56+_NKCells5.8
CD71+_EarlyErythroid4.55
CD8+_Tcells4.7
CardiacMyocytes6.1
Caudatenucleus4.25
Cerebellum3.8
CerebellumPeduncles5.35
CiliaryGanglion3.45
CingulateCortex4.8
Colorectaladenocarcinoma4.85
DorsalRootGanglion3.55
FetalThyroid4.6
Fetalbrain4.75
Fetalliver4.2
Fetallung4
GlobusPallidus3.45
Heart6.55
Hypothalamus5.1
Kidney3.75
Leukemia_chronicMyelogenousK-5624.3
Leukemia_promyelocytic-HL-604.5
Leukemialymphoblastic(MOLT-4)3.75
Liver6.25
Lung5.25
Lymphnode4.15
Lymphoma_burkitts(Daudi)6.05
Lymphoma_burkitts(Raji)7
MedullaOblongata4.25
OccipitalLobe4.2
OlfactoryBulb3.75
Ovary3.2
Pancreas3.75
PancreaticIslet5.05
ParietalLobe4.95
Pituitary5.55
Placenta4.95
Pons4.55
PrefrontalCortex5.9
Prostate5.65
Salivarygland3.7
SkeletalMuscle6.1
Skin3.7
SmoothMuscle5.45
Spinalcord5.05
SubthalamicNucleus4.25
SuperiorCervicalGanglion5.25
TemporalLobe4.35
Testis4.1
TestisGermCell3.95
TestisIntersitial4.4
TestisLeydigCell4.65
TestisSeminiferousTubule4.1
Thalamus4.85
Thymus3.8
Thyroid6.05
Tongue4.6
Tonsil4.6
Trachea3.95
TrigeminalGanglion5.25
Uterus3.95
UterusCorpus4.15
WholeBlood5.25
Wholebrain3.95
colon4.75
pineal_day5.94
pineal_night5.84
retina5.75
small_intestine4.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_777_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.81 ± 0.77
Basal Forebrain3.09 ± 0.51
Basal Part of Pons3.25 ± 0.36
Cerebellar Cortex4.1 ± 0.46
Cerebellar Nuclei3.24 ± 0.46
Claustrum4.06 ± 0.7
Epithalamus3.31 ± 0.83
Frontal Lobe3.54 ± 0.69
Globus Pallidus2.76 ± 0.66
Hypothalamus3.17 ± 0.69
Insula3.45 ± 0.54
Limbic Lobe3.87 ± 0.63
Mesencephalon3.63 ± 0.75
Myelencephalon3.63 ± 0.61
Occipital Lobe3.9 ± 0.77
Parietal Lobe3.71 ± 0.72
Pontine Tegmentum3.7 ± 0.7
Striatum3.56 ± 0.73
Subthalamus3.78 ± 1.05
Temporal Lobe3.72 ± 0.61
Thalamus3.52 ± 0.61
White Matter3.5 ± 0.17
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
H2A1B_HUMAN_100 19 100 118 VTIAQGGVLPNIQAVLLPK PRIDE
H2A1B_HUMAN_21 9 21 29 AGLQFPVGR PRIDE
H2A1B_HUMAN_82 7 82 88 HLQLAIR PRIDE
H2A1B_HUMAN_89 11 89 99 NDEELNKLLGR PRIDE
PAp00003434 14 83 96 HLQLAIRNDEELNK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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