AutismKB 2.0

Annotation Detail for HAGH


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Basic Information Top
Gene Symbol:HAGH ( GLO2,GLX2,GLXII,HAGH1 )
Gene Full Name: hydroxyacylglutathione hydrolase
Band: 16p13.3
Quick LinksEntrez ID:3029; OMIM: 138760; Uniprot ID:GLO2_HUMAN; ENSEMBL ID: ENSG00000063854; HGNC ID: 4805
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst2 / 6231932
fetus16 / 56401228
neonate0 / 310970 
infant2 / 2362084
juvenile1 / 5555617
adult91 / 193912146
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor1 / 3436629
chondrosarcoma5 / 8282360
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor8 / 11936967
germ cell tumor11 / 26384541
glioma10 / 10688393
head and neck tumor2 / 13630214
kidney tumor0 / 689590 
leukemia3 / 9584231
liver tumor1 / 9635910
lung tumor4 / 10312738
lymphoma2 / 7175527
non-neoplasia3 / 9725030
normal176 / 336030752
ovarian tumor1 / 7668213
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer3 / 10268029
retinoblastoma3 / 4635664
skin tumor3 / 12494924
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood3 / 12347824
bone0 / 716550 
bone marrow1 / 4880120
brain79 / 110098971
cervix3 / 4817162
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue8 / 21572237
esophagus0 / 202090 
eye8 / 21105437
heart6 / 8962666
intestine3 / 23447212
kidney37 / 211777174
larynx1 / 2414541
liver4 / 20774319
lung32 / 33697494
lymph0 / 442700 
lymph node5 / 9161054
mammary gland2 / 15327113
mouth0 / 670520 
muscle4 / 10771537
nerve1 / 1576863
ovary2 / 10205119
pancreas12 / 21481255
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland20 / 165851205
placenta6 / 28082521
prostate11 / 18934558
salivary gland1 / 2015549
skin5 / 21057423
spleen1 / 5395218
stomach5 / 9661951
testis26 / 33044278
thymus1 / 8113112
thyroid1 / 4747321
tonsil1 / 1699958
trachea0 / 524130 
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205012_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts108.3
Adipocyte126.35
AdrenalCortex172.7
Adrenalgland168.25
Amygdala252.4
Appendix119.25
AtrioventricularNode68.9
BDCA4+_DentriticCells189.5
Bonemarrow180.55
BronchialEpithelialCells119.45
CD105+_Endothelial913.4
CD14+_Monocytes165.35
CD19+_BCells(neg._sel.)137.7
CD33+_Myeloid159.6
CD34+213.95
CD4+_Tcells146.7
CD56+_NKCells234.8
CD71+_EarlyErythroid2050.1
CD8+_Tcells204.25
CardiacMyocytes154.9
Caudatenucleus123.35
Cerebellum162.65
CerebellumPeduncles244.2
CiliaryGanglion76.05
CingulateCortex203.55
Colorectaladenocarcinoma132.85
DorsalRootGanglion86.2
FetalThyroid113.65
Fetalbrain120.25
Fetalliver141.85
Fetallung109.25
GlobusPallidus97.55
Heart581
Hypothalamus299.5
Kidney213.9
Leukemia_chronicMyelogenousK-562103
Leukemia_promyelocytic-HL-6066.9
Leukemialymphoblastic(MOLT-4)134.85
Liver1339
Lung224.3
Lymphnode104.8
Lymphoma_burkitts(Daudi)125.4
Lymphoma_burkitts(Raji)174.8
MedullaOblongata139.75
OccipitalLobe131.1
OlfactoryBulb113.65
Ovary64.45
Pancreas65.85
PancreaticIslet132.8
ParietalLobe136.8
Pituitary143
Placenta73.3
Pons125.2
PrefrontalCortex349.85
Prostate164.9
Salivarygland100.95
SkeletalMuscle142.1
Skin91.2
SmoothMuscle74.85
Spinalcord138.2
SubthalamicNucleus142.75
SuperiorCervicalGanglion91.15
TemporalLobe210.35
Testis288.5
TestisGermCell281.05
TestisIntersitial176.6
TestisLeydigCell196.05
TestisSeminiferousTubule193.05
Thalamus275.15
Thymus97.1
Thyroid168.1
Tongue124.2
Tonsil81.8
Trachea84.4
TrigeminalGanglion108.9
Uterus76.25
UterusCorpus99.65
WholeBlood72.5
Wholebrain379.05
colon134.35
pineal_day546.32
pineal_night382.5
retina173.15
small_intestine117.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P176445
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.93 ± 0.86
Basal Forebrain8.27 ± 0.26
Basal Part of Pons9.03 ± 0.51
Cerebellar Cortex8.79 ± 0.41
Cerebellar Nuclei8.19 ± 0.53
Claustrum7.92 ± 0.79
Epithalamus8.61 ± 0.29
Frontal Lobe8.8 ± 0.46
Globus Pallidus7.83 ± 0.28
Hypothalamus8.74 ± 0.4
Insula8.84 ± 0.41
Limbic Lobe8.51 ± 0.61
Mesencephalon8.22 ± 0.54
Myelencephalon8.4 ± 0.64
Occipital Lobe7.83 ± 0.64
Parietal Lobe8.46 ± 0.52
Pontine Tegmentum8.44 ± 0.47
Striatum7.74 ± 0.51
Subthalamus8.66 ± 0.41
Temporal Lobe8.72 ± 0.47
Thalamus8.35 ± 0.44
White Matter7.81 ± 0.46
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
HaghCBCerebellum41.8
100
HaghCTXCerebral cortex100
100
HaghHIPHippocampal region100
100
HaghHPFHippocampal formation100
100
HaghHYHypothalamus54.71
56.77
HaghLSXLateral septal complex6.3
4.34
HaghMBMidbrain58.04
67.38
HaghMYMedulla51.56
77.8
HaghOLFOlfactory bulb100
100
HaghPPons54.23
75.48
HaghPALPallidum57.68
66.59
HaghRHPRetrohippocampal region100
100
HaghsAMYStriatum-like amygdalar nuclei59.44
62.38
HaghSTRStriatum70.95
67.07
HaghSTRdStriatum dorsal region70.76
65.47
HaghSTRvStriatum ventral region77.61
74.24
HaghTHThalamus91.09
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
GLO2_HUMAN_0 0 0 0 ITHLSTLQVGSLNVK PRIDE
GLO2_HUMAN_185 10 185 194 HVEPGNAAIR PRIDE
GLO2_HUMAN_231 16 231 246 TVQQHAGETDPVTTMR PRIDE
PAp00008707 13 169 181 VYCGHEYTINNLK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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