AutismKB 2.0

Annotation Detail for HAL


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Basic Information Top
Gene Symbol:HAL ( HIS,HSTD )
Gene Full Name: histidine ammonia-lyase
Band: 12q23.1
Quick LinksEntrez ID:3034; OMIM: 609457; Uniprot ID:HUTH_HUMAN; ENSEMBL ID: ENSG00000084110; HGNC ID: 4806
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus21 / 56401237
neonate1 / 3109732
infant0 / 236200 
juvenile0 / 555560 
adult27 / 193912113
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia7 / 9584273
liver tumor8 / 9635983
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal48 / 336030714
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood9 / 12347872
bone0 / 716550 
bone marrow0 / 488010 
brain0 / 11009890 
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart5 / 8962655
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver30 / 207743144
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle2 / 10771518
nerve0 / 157680 
ovary0 / 1020510 
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin3 / 21057414
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 217521_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.1
Adipocyte4.15
AdrenalCortex4.35
Adrenalgland3.55
Amygdala4.35
Appendix4.25
AtrioventricularNode3.3
BDCA4+_DentriticCells4.6
Bonemarrow4.2
BronchialEpithelialCells4.1
CD105+_Endothelial4.25
CD14+_Monocytes13.8
CD19+_BCells(neg._sel.)4.45
CD33+_Myeloid15.55
CD34+5.45
CD4+_Tcells4.45
CD56+_NKCells5
CD71+_EarlyErythroid3.9
CD8+_Tcells4
CardiacMyocytes5.25
Caudatenucleus3.75
Cerebellum3.4
CerebellumPeduncles4.75
CiliaryGanglion3
CingulateCortex4.3
Colorectaladenocarcinoma4.25
DorsalRootGanglion3.2
FetalThyroid4.1
Fetalbrain4.15
Fetalliver113.25
Fetallung6.45
GlobusPallidus3.15
Heart5.4
Hypothalamus4.5
Kidney3.45
Leukemia_chronicMyelogenousK-5623.8
Leukemia_promyelocytic-HL-603.7
Leukemialymphoblastic(MOLT-4)3.35
Liver5.6
Lung4.65
Lymphnode3.6
Lymphoma_burkitts(Daudi)5.35
Lymphoma_burkitts(Raji)5.9
MedullaOblongata3.9
OccipitalLobe3.8
OlfactoryBulb3.3
Ovary2.8
Pancreas3.35
PancreaticIslet4.5
ParietalLobe4.45
Pituitary4.9
Placenta4.25
Pons4
PrefrontalCortex5.15
Prostate4.95
Salivarygland3.35
SkeletalMuscle4.9
Skin3.3
SmoothMuscle4.75
Spinalcord4.5
SubthalamicNucleus3.8
SuperiorCervicalGanglion4.9
TemporalLobe3.9
Testis3.65
TestisGermCell3.5
TestisIntersitial3.55
TestisLeydigCell4.2
TestisSeminiferousTubule3.6
Thalamus4.3
Thymus3.35
Thyroid5.2
Tongue5.1
Tonsil4.1
Trachea3.5
TrigeminalGanglion5.2
Uterus3.4
UterusCorpus3.8
WholeBlood8.6
Wholebrain3.6
colon4.25
pineal_day5.18
pineal_night5.12
retina5.025
small_intestine4.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_7651_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala1.95 ± 1
Basal Forebrain1.48 ± 0.19
Basal Part of Pons1.23 ± 0.39
Cerebellar Cortex1.31 ± 0.67
Cerebellar Nuclei1.76 ± 0.71
Claustrum2.36 ± 0.83
Epithalamus1.21 ± 0.69
Frontal Lobe1.32 ± 0.56
Globus Pallidus2.2 ± 0.4
Hypothalamus1.59 ± 0.64
Insula1.38 ± 0.48
Limbic Lobe1.5 ± 0.61
Mesencephalon1.65 ± 0.69
Myelencephalon1.52 ± 0.64
Occipital Lobe1.56 ± 0.6
Parietal Lobe1.6 ± 0.9
Pontine Tegmentum1.52 ± 0.64
Striatum1.63 ± 0.45
Subthalamus1.64 ± 0.62
Temporal Lobe1.37 ± 0.51
Thalamus1.47 ± 0.57
White Matter2.12 ± 0.33
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018