AutismKB 2.0

Annotation Detail for HARS


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Basic Information Top
Gene Symbol:HARS ( FLJ20491,HRS )
Gene Full Name: histidyl-tRNA synthetase
Band: 5q31.3
Quick LinksEntrez ID:3035; OMIM: 142810; Uniprot ID:SYHC_HUMAN; ENSEMBL ID: ENSG00000170445; HGNC ID: 4816
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst8 / 62319128
fetus53 / 56401293
neonate8 / 31097257
infant2 / 2362084
juvenile13 / 55556233
adult177 / 193912191
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma0 / 174750 
breast (mammary gland) tumor11 / 94178116
cervical tumor6 / 34366174
chondrosarcoma7 / 8282384
colorectal tumor18 / 114246157
esophageal tumor5 / 17290289
gastrointestinal tumor15 / 119369125
germ cell tumor45 / 263845170
glioma13 / 106883121
head and neck tumor12 / 13630288
kidney tumor20 / 68959290
leukemia8 / 9584283
liver tumor15 / 96359155
lung tumor13 / 103127126
lymphoma9 / 71755125
non-neoplasia16 / 97250164
normal469 / 3360307139
ovarian tumor8 / 76682104
pancreatic tumor11 / 104616105
primitive neuroectodermal tumor of the CNS26 / 125680206
prostate cancer7 / 10268068
retinoblastoma6 / 46356129
skin tumor36 / 124949288
soft tissue/muscle tissue tumor16 / 125191127
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland10 / 33197301
ascites7 / 40015174
bladder7 / 29757235
blood15 / 123478121
bone4 / 7165555
bone marrow3 / 4880161
brain263 / 1100989238
cervix9 / 48171186
connective tissue13 / 14925587
ear1 / 1621261
embryonic tissue21 / 21572297
esophagus6 / 20209296
eye25 / 211054118
heart5 / 8962655
intestine33 / 234472140
kidney36 / 211777169
larynx6 / 24145248
liver22 / 207743105
lung44 / 336974130
lymph9 / 44270203
lymph node6 / 9161065
mammary gland19 / 153271123
mouth0 / 670520 
muscle6 / 10771555
nerve0 / 157680 
ovary12 / 102051117
pancreas13 / 21481260
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta26 / 28082592
prostate17 / 18934589
salivary gland1 / 2015549
skin47 / 210574223
spleen9 / 53952166
stomach10 / 96619103
testis61 / 330442184
thymus16 / 81131197
thyroid5 / 47473105
tonsil4 / 16999235
trachea0 / 524130 
umbilical cord3 / 13680219
uterus35 / 232878150
vascular6 / 51780115
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202042_at
Cell line Expression level Expression bar
721_B_lymphoblasts429.4
Adipocyte54.1
AdrenalCortex30.65
Adrenalgland48.45
Amygdala132.75
Appendix18.65
AtrioventricularNode16
BDCA4+_DentriticCells192.45
Bonemarrow32.95
BronchialEpithelialCells184.4
CD105+_Endothelial397.85
CD14+_Monocytes70.7
CD19+_BCells(neg._sel.)75.1
CD33+_Myeloid69.95
CD34+186.15
CD4+_Tcells226
CD56+_NKCells254.25
CD71+_EarlyErythroid169.4
CD8+_Tcells190.35
CardiacMyocytes142.25
Caudatenucleus150.15
Cerebellum89.95
CerebellumPeduncles90.4
CiliaryGanglion16.65
CingulateCortex210.15
Colorectaladenocarcinoma237.3
DorsalRootGanglion12.45
FetalThyroid59.3
Fetalbrain185.15
Fetalliver35.7
Fetallung52.9
GlobusPallidus58.55
Heart27.1
Hypothalamus270.1
Kidney28.2
Leukemia_chronicMyelogenousK-562132.2
Leukemia_promyelocytic-HL-6094
Leukemialymphoblastic(MOLT-4)98.2
Liver27.5
Lung59.35
Lymphnode58.15
Lymphoma_burkitts(Daudi)112.3
Lymphoma_burkitts(Raji)50.05
MedullaOblongata129.25
OccipitalLobe139.5
OlfactoryBulb37.1
Ovary16.95
Pancreas35.6
PancreaticIslet63.4
ParietalLobe105.95
Pituitary111.2
Placenta30.9
Pons100.45
PrefrontalCortex326.5
Prostate56.3
Salivarygland37.75
SkeletalMuscle29.9
Skin17.65
SmoothMuscle244.75
Spinalcord81.8
SubthalamicNucleus126.75
SuperiorCervicalGanglion27.1
TemporalLobe124.65
Testis52.45
TestisGermCell69.75
TestisIntersitial46.9
TestisLeydigCell55.4
TestisSeminiferousTubule57.4
Thalamus357.85
Thymus88.65
Thyroid61.45
Tongue33.95
Tonsil53.7
Trachea21.3
TrigeminalGanglion21.7
Uterus29.15
UterusCorpus28.25
WholeBlood37.15
Wholebrain294.75
colon86.15
pineal_day189.5
pineal_night159.7
retina121.575
small_intestine113.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P89284
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.18 ± 0.34
Basal Forebrain9 ± 0.23
Basal Part of Pons9.41 ± 0.19
Cerebellar Cortex9.03 ± 0.22
Cerebellar Nuclei9.25 ± 0.19
Claustrum9.37 ± 0.47
Epithalamus8.63 ± 0.22
Frontal Lobe9.22 ± 0.32
Globus Pallidus9 ± 0.2
Hypothalamus8.97 ± 0.19
Insula9.16 ± 0.23
Limbic Lobe9.26 ± 0.31
Mesencephalon9.25 ± 0.33
Myelencephalon9.16 ± 0.34
Occipital Lobe9.31 ± 0.26
Parietal Lobe9.3 ± 0.29
Pontine Tegmentum9.21 ± 0.25
Striatum9.34 ± 0.32
Subthalamus9.24 ± 0.17
Temporal Lobe9.2 ± 0.24
Thalamus9.46 ± 0.35
White Matter8.52 ± 0.23
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
SYHC_HUMAN_363 11 363 373 YDGLVGMFDPK PRIDE
SYHC_HUMAN_52 12 52 63 QKFVLKTPKGTR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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