AutismKB 2.0

Annotation Detail for HCK


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Basic Information Top
Gene Symbol:HCK ( JTK9 )
Gene Full Name: hemopoietic cell kinase
Band: 20q11.21
Quick LinksEntrez ID:3055; OMIM: 142370; Uniprot ID:HCK_HUMAN; ENSEMBL ID: ENSG00000101336; HGNC ID: 4840
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus7 / 56401212
neonate11 / 31097353
infant0 / 236200 
juvenile0 / 555560 
adult42 / 193912121
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor0 / 941780 
cervical tumor1 / 3436629
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor1 / 1729057
gastrointestinal tumor0 / 1193690 
germ cell tumor4 / 26384515
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia8 / 9584283
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma5 / 7175569
non-neoplasia4 / 9725041
normal112 / 336030733
ovarian tumor1 / 7668213
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood35 / 123478283
bone0 / 716550 
bone marrow0 / 488010 
brain6 / 11009895
cervix1 / 4817120
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus1 / 2020949
eye4 / 21105418
heart0 / 896260 
intestine4 / 23447217
kidney4 / 21177718
larynx0 / 241450 
liver0 / 2077430 
lung19 / 33697456
lymph3 / 4427067
lymph node3 / 9161032
mammary gland1 / 1532716
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary1 / 1020519
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta8 / 28082528
prostate2 / 18934510
salivary gland0 / 201550 
skin4 / 21057418
spleen9 / 53952166
stomach1 / 9661910
testis1 / 3304423
thymus4 / 8113149
thyroid0 / 474730 
tonsil1 / 1699958
trachea0 / 524130 
umbilical cord1 / 1368073
uterus6 / 23287825
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208018_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts63
Adipocyte6.7
AdrenalCortex8.9
Adrenalgland7.8
Amygdala9.5
Appendix9.15
AtrioventricularNode5.6
BDCA4+_DentriticCells539.25
Bonemarrow210.8
BronchialEpithelialCells7.1
CD105+_Endothelial28.85
CD14+_Monocytes2175.2
CD19+_BCells(neg._sel.)113.5
CD33+_Myeloid1904.8
CD34+11.9
CD4+_Tcells8.75
CD56+_NKCells464.95
CD71+_EarlyErythroid7.85
CD8+_Tcells7.8
CardiacMyocytes19.4
Caudatenucleus7.45
Cerebellum6.9
CerebellumPeduncles9.65
CiliaryGanglion5.9
CingulateCortex9.3
Colorectaladenocarcinoma10.3
DorsalRootGanglion6.7
FetalThyroid8.25
Fetalbrain8.35
Fetalliver12.3
Fetallung27.25
GlobusPallidus5.65
Heart92.55
Hypothalamus8.95
Kidney9.35
Leukemia_chronicMyelogenousK-5627.55
Leukemia_promyelocytic-HL-607.35
Leukemialymphoblastic(MOLT-4)6.4
Liver17.7
Lung208.05
Lymphnode46.3
Lymphoma_burkitts(Daudi)13.95
Lymphoma_burkitts(Raji)23.95
MedullaOblongata7.55
OccipitalLobe5.9
OlfactoryBulb6.5
Ovary5.3
Pancreas7
PancreaticIslet10.15
ParietalLobe9
Pituitary9.8
Placenta23.15
Pons8.3
PrefrontalCortex9.3
Prostate11.25
Salivarygland7.35
SkeletalMuscle11.45
Skin6.4
SmoothMuscle9.45
Spinalcord15.45
SubthalamicNucleus7.75
SuperiorCervicalGanglion10.55
TemporalLobe7.95
Testis8.1
TestisGermCell6.85
TestisIntersitial7.3
TestisLeydigCell8.75
TestisSeminiferousTubule8.7
Thalamus8.75
Thymus14.45
Thyroid10.65
Tongue9.85
Tonsil64.85
Trachea8.45
TrigeminalGanglion8.8
Uterus6.95
UterusCorpus10.7
WholeBlood2427.15
Wholebrain7.85
colon17
pineal_day9.66
pineal_night10.16
retina25.75
small_intestine39
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_9876_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.78 ± 0.69
Basal Forebrain3.01 ± 0.79
Basal Part of Pons3.24 ± 0.59
Cerebellar Cortex3.22 ± 0.43
Cerebellar Nuclei3.85 ± 0.42
Claustrum3.43 ± 0.59
Epithalamus3.81 ± 0.47
Frontal Lobe3.23 ± 0.68
Globus Pallidus4.61 ± 0.5
Hypothalamus3.21 ± 0.81
Insula3.12 ± 0.77
Limbic Lobe3.4 ± 0.64
Mesencephalon3.28 ± 0.75
Myelencephalon3.3 ± 0.6
Occipital Lobe3.26 ± 0.6
Parietal Lobe3.2 ± 0.85
Pontine Tegmentum3.25 ± 0.78
Striatum3.43 ± 0.72
Subthalamus3.67 ± 0.45
Temporal Lobe3.29 ± 0.58
Thalamus3.22 ± 0.68
White Matter4.66 ± 0.63
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
HckCBCerebellum2.05
2.24
HckCTXCerebral cortex2.98
2.2
HckHIPHippocampal region2.93
3.1
HckHPFHippocampal formation2.59
2.51
HckHYHypothalamus10.98
8.22
HckLSXLateral septal complex0.84
0.89
HckMBMidbrain7.57
6.88
HckMYMedulla10.19
8.95
HckOLFOlfactory bulb7.65
7.67
HckPPons10.27
10.02
HckPALPallidum2.16
1.57
HckRHPRetrohippocampal region1.9
1.53
HcksAMYStriatum-like amygdalar nuclei0.51
0.41
HckSTRStriatum1.04
0.81
HckSTRdStriatum dorsal region0.23
0.22
HckSTRvStriatum ventral region3.84
2.46
HckTHThalamus5.16
3.67
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00036286 17 476 492 MPRPENCPEELYNIMMR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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