AutismKB 2.0

Annotation Detail for HCLS1


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Basic Information Top
Gene Symbol:HCLS1 ( CTTNL,HS1 )
Gene Full Name: hematopoietic cell-specific Lyn substrate 1
Band: 3q13.33
Quick LinksEntrez ID:3059; OMIM: 601306; Uniprot ID:HCLS1_HUMAN; ENSEMBL ID: ENSG00000180353; HGNC ID: 4844
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus29 / 56401251
neonate2 / 3109764
infant0 / 236200 
juvenile10 / 55556179
adult121 / 193912162
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor1 / 3436629
chondrosarcoma9 / 82823108
colorectal tumor3 / 11424626
esophageal tumor1 / 1729057
gastrointestinal tumor3 / 11936925
germ cell tumor14 / 26384553
glioma2 / 10688318
head and neck tumor2 / 13630214
kidney tumor4 / 6895958
leukemia25 / 95842260
liver tumor1 / 9635910
lung tumor2 / 10312719
lymphoma84 / 717551170
non-neoplasia18 / 97250185
normal291 / 336030786
ovarian tumor0 / 766820 
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood65 / 123478526
bone3 / 7165541
bone marrow4 / 4880181
brain36 / 110098932
cervix1 / 4817120
connective tissue24 / 149255160
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus1 / 2020949
eye10 / 21105447
heart5 / 8962655
intestine15 / 23447263
kidney6 / 21177728
larynx1 / 2414541
liver6 / 20774328
lung17 / 33697450
lymph75 / 442701694
lymph node18 / 91610196
mammary gland3 / 15327119
mouth1 / 6705214
muscle2 / 10771518
nerve1 / 1576863
ovary3 / 10205129
pancreas8 / 21481237
parathyroid0 / 205390 
pharynx23 / 41328556
pituitary gland0 / 165850 
placenta29 / 280825103
prostate1 / 1893455
salivary gland0 / 201550 
skin0 / 2105740 
spleen35 / 53952648
stomach4 / 9661941
testis3 / 3304429
thymus30 / 81131369
thyroid0 / 474730 
tonsil6 / 16999352
trachea4 / 5241376
umbilical cord0 / 136800 
uterus7 / 23287830
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202957_at
Cell line Expression level Expression bar
721_B_lymphoblasts791.5
Adipocyte4.2
AdrenalCortex4.55
Adrenalgland6.3
Amygdala4.65
Appendix4.85
AtrioventricularNode3.35
BDCA4+_DentriticCells994.7
Bonemarrow248.45
BronchialEpithelialCells4.2
CD105+_Endothelial126.1
CD14+_Monocytes1001.1
CD19+_BCells(neg._sel.)870.7
CD33+_Myeloid1764.15
CD34+551.65
CD4+_Tcells770.55
CD56+_NKCells1303.9
CD71+_EarlyErythroid4.55
CD8+_Tcells709.55
CardiacMyocytes5.3
Caudatenucleus3.85
Cerebellum3.5
CerebellumPeduncles4.8
CiliaryGanglion3.55
CingulateCortex4.35
Colorectaladenocarcinoma4.25
DorsalRootGanglion4.6
FetalThyroid4.2
Fetalbrain4.3
Fetalliver5.2
Fetallung11.85
GlobusPallidus3.05
Heart32.95
Hypothalamus6.2
Kidney3.4
Leukemia_chronicMyelogenousK-56214.7
Leukemia_promyelocytic-HL-60212.15
Leukemialymphoblastic(MOLT-4)130
Liver6.45
Lung47.8
Lymphnode260.4
Lymphoma_burkitts(Daudi)305.35
Lymphoma_burkitts(Raji)148.3
MedullaOblongata3.8
OccipitalLobe3.9
OlfactoryBulb33
Ovary3.05
Pancreas3.85
PancreaticIslet38.05
ParietalLobe4.45
Pituitary5.65
Placenta40.1
Pons4.05
PrefrontalCortex5.55
Prostate5.1
Salivarygland16.5
SkeletalMuscle4.7
Skin3.5
SmoothMuscle4.9
Spinalcord11.75
SubthalamicNucleus3.85
SuperiorCervicalGanglion5.6
TemporalLobe3.85
Testis3.7
TestisGermCell3.45
TestisIntersitial3.55
TestisLeydigCell4.2
TestisSeminiferousTubule3.7
Thalamus4.35
Thymus198.85
Thyroid5.5
Tongue4.4
Tonsil288
Trachea8.35
TrigeminalGanglion4.3
Uterus3.6
UterusCorpus3.8
WholeBlood1140.8
Wholebrain3.65
colon4.6
pineal_day8.26
pineal_night5.42
retina28.95
small_intestine17.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_1646_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.08 ± 1.06
Basal Forebrain2.27 ± 0.24
Basal Part of Pons2.95 ± 0.57
Cerebellar Cortex2.2 ± 0.68
Cerebellar Nuclei3.07 ± 0.64
Claustrum3.24 ± 0.74
Epithalamus2.77 ± 0.66
Frontal Lobe2.47 ± 0.73
Globus Pallidus4.24 ± 0.35
Hypothalamus2.67 ± 1
Insula3.15 ± 1
Limbic Lobe2.57 ± 0.81
Mesencephalon2.78 ± 0.85
Myelencephalon2.71 ± 0.77
Occipital Lobe2.77 ± 0.83
Parietal Lobe2.49 ± 0.99
Pontine Tegmentum2.39 ± 0.73
Striatum2.81 ± 0.68
Subthalamus2.97 ± 0.3
Temporal Lobe2.58 ± 0.82
Thalamus2.48 ± 0.64
White Matter3.8 ± 0.19
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Hcls1CBCerebellum73.9
100
Hcls1CTXCerebral cortex100
100
Hcls1HIPHippocampal region100
100
Hcls1HPFHippocampal formation100
100
Hcls1HYHypothalamus100
99.77
Hcls1LSXLateral septal complex100
100
Hcls1MBMidbrain100
100
Hcls1MYMedulla97.28
100
Hcls1OLFOlfactory bulb100
100
Hcls1PPons98.9
100
Hcls1PALPallidum100
100
Hcls1RHPRetrohippocampal region100
100
Hcls1sAMYStriatum-like amygdalar nuclei100
100
Hcls1STRStriatum100
100
Hcls1STRdStriatum dorsal region100
100
Hcls1STRvStriatum ventral region100
100
Hcls1THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
HCLS1_HUMAN_133 13 133 145 SAVGFDYKGEVEK PRIDE
HCLS1_HUMAN_170 18 170 187 AALGYDYKGETEKHESQR PRIDE
HCLS1_HUMAN_190 15 190 204 YAKGFGGQYGIQKDR PRIDE
HCLS1_HUMAN_269 27 269 295 AVTKRSPEAPQPVIAMEEPAVPAPLPK PRIDE
HCLS1_HUMAN_274 23 274 296 RSPEAPQPVIAMEEPAVPAPLPK PRIDE
HCLS1_HUMAN_275 22 275 296 SPEAPQPVIAMEEPAVPAPLPK PRIDE
HCLS1_HUMAN_332 16 332 347 QTLPEDNEEPPALPPR PRIDE
HCLS1_HUMAN_47 12 47 58 GRTEHINIHQLR PRIDE
HCLS1_HUMAN_96 22 96 117 SAVGHEYVAEVEKHSSQTDAAK PRIDE
PAp00001054 14 470 483 CHGHFGLFPANYVK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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