AutismKB 2.0

Annotation Detail for HDAC1


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Basic Information Top
Gene Symbol:HDAC1 ( DKFZp686H12203,GON-10,HD1,RPD3,RPD3L1 )
Gene Full Name: histone deacetylase 1
Band: 1p35.2-p35.1
Quick LinksEntrez ID:3065; OMIM: 601241; Uniprot ID:HDAC1_HUMAN; ENSEMBL ID: ENSG00000116478; HGNC ID: 4852
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body16 / 70761226
blastocyst13 / 62319208
fetus43 / 56401276
neonate1 / 3109732
infant0 / 236200 
juvenile12 / 55556215
adult614 / 1939121316
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma2 / 17475114
breast (mammary gland) tumor103 / 941781093
cervical tumor4 / 34366116
chondrosarcoma21 / 82823253
colorectal tumor56 / 114246490
esophageal tumor2 / 17290115
gastrointestinal tumor218 / 1193691826
germ cell tumor29 / 263845109
glioma8 / 10688374
head and neck tumor126 / 136302924
kidney tumor18 / 68959261
leukemia18 / 95842187
liver tumor7 / 9635972
lung tumor18 / 103127174
lymphoma30 / 71755418
non-neoplasia7 / 9725071
normal294 / 336030787
ovarian tumor13 / 76682169
pancreatic tumor23 / 104616219
primitive neuroectodermal tumor of the CNS18 / 125680143
prostate cancer11 / 102680107
retinoblastoma2 / 4635643
skin tumor14 / 124949112
soft tissue/muscle tissue tumor10 / 12519179
uterine tumor27 / 90257299
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites10 / 40015249
bladder6 / 29757201
blood26 / 123478210
bone15 / 71655209
bone marrow3 / 4880161
brain43 / 110098939
cervix4 / 4817183
connective tissue9 / 14925560
ear0 / 162120 
embryonic tissue41 / 215722190
esophagus2 / 2020998
eye20 / 21105494
heart7 / 8962678
intestine72 / 234472307
kidney28 / 211777132
larynx1 / 2414541
liver15 / 20774372
lung54 / 336974160
lymph26 / 44270587
lymph node17 / 91610185
mammary gland105 / 153271685
mouth115 / 670521715
muscle4 / 10771537
nerve0 / 157680 
ovary19 / 102051186
pancreas30 / 214812139
parathyroid1 / 2053948
pharynx11 / 41328266
pituitary gland1 / 1658560
placenta21 / 28082574
prostate18 / 18934595
salivary gland3 / 20155148
skin19 / 21057490
spleen2 / 5395237
stomach206 / 966192132
testis23 / 33044269
thymus3 / 8113136
thyroid11 / 47473231
tonsil10 / 16999588
trachea0 / 524130 
umbilical cord0 / 136800 
uterus38 / 232878163
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201209_at
Cell line Expression level Expression bar
721_B_lymphoblasts1140.55
Adipocyte47.4
AdrenalCortex84.35
Adrenalgland97.2
Amygdala22.05
Appendix56.95
AtrioventricularNode24.45
BDCA4+_DentriticCells534.85
Bonemarrow98.95
BronchialEpithelialCells343.2
CD105+_Endothelial375.05
CD14+_Monocytes392.6
CD19+_BCells(neg._sel.)815.2
CD33+_Myeloid561.1
CD34+743
CD4+_Tcells1071.55
CD56+_NKCells783.05
CD71+_EarlyErythroid335.45
CD8+_Tcells987.6
CardiacMyocytes108.55
Caudatenucleus24.1
Cerebellum18.95
CerebellumPeduncles16.6
CiliaryGanglion17.8
CingulateCortex13.75
Colorectaladenocarcinoma222.9
DorsalRootGanglion19.55
FetalThyroid164.7
Fetalbrain51.75
Fetalliver88.95
Fetallung108.2
GlobusPallidus17.5
Heart56.55
Hypothalamus55.1
Kidney68.2
Leukemia_chronicMyelogenousK-562301.7
Leukemia_promyelocytic-HL-60397.9
Leukemialymphoblastic(MOLT-4)426.45
Liver80.45
Lung134.65
Lymphnode244.1
Lymphoma_burkitts(Daudi)571.55
Lymphoma_burkitts(Raji)433.7
MedullaOblongata25.85
OccipitalLobe22.45
OlfactoryBulb87.4
Ovary49.5
Pancreas158.3
PancreaticIslet162.9
ParietalLobe49.1
Pituitary129.05
Placenta168.55
Pons29.4
PrefrontalCortex73.6
Prostate277.85
Salivarygland119.55
SkeletalMuscle43
Skin36.15
SmoothMuscle236.2
Spinalcord42.15
SubthalamicNucleus15.8
SuperiorCervicalGanglion49.8
TemporalLobe29.15
Testis126.3
TestisGermCell165.65
TestisIntersitial96.75
TestisLeydigCell102
TestisSeminiferousTubule110.05
Thalamus32.2
Thymus363.45
Thyroid373.85
Tongue104.25
Tonsil281
Trachea94.4
TrigeminalGanglion38.55
Uterus116.05
UterusCorpus24.95
WholeBlood360.75
Wholebrain17.5
colon564.55
pineal_day214
pineal_night211.98
retina154.15
small_intestine403.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16046_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.29 ± 0.48
Basal Forebrain5.37 ± 0.19
Basal Part of Pons4.77 ± 0.48
Cerebellar Cortex4.72 ± 0.34
Cerebellar Nuclei5.74 ± 0.52
Claustrum5.72 ± 0.74
Epithalamus5.17 ± 0.28
Frontal Lobe4.93 ± 0.5
Globus Pallidus6.44 ± 0.26
Hypothalamus4.76 ± 0.75
Insula5.01 ± 0.33
Limbic Lobe5.33 ± 0.72
Mesencephalon5.28 ± 0.42
Myelencephalon5.26 ± 0.65
Occipital Lobe5.65 ± 0.81
Parietal Lobe5.24 ± 0.61
Pontine Tegmentum5.2 ± 0.49
Striatum5.55 ± 0.64
Subthalamus5.3 ± 0.25
Temporal Lobe5.06 ± 0.52
Thalamus5.14 ± 0.52
White Matter6.46 ± 0.39
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00025833 19 414 432 IACEEEFSDSEEEGEGGRK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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