Annotation Detail for NRG1
Basic Information Top
| Gene Symbol: | NRG1 ( ARIA,GGF,GGF2,HGL,HRG,HRG1,HRGA,MST131,NDF,SMDF ) |
|---|---|
| Gene Full Name: | neuregulin 1 |
| Band: | 8p12 |
| Quick Links | Entrez ID:3084; OMIM: 142445; Uniprot ID:NRG1_HUMAN; ENSEMBL ID: ENSG00000157168; HGNC ID: 7997 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.453951
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 0 / 70761 | 0 | |
| blastocyst | 1 / 62319 | 16 |  |
| fetus | 19 / 564012 | 33 | |
| neonate | 1 / 31097 | 32 | |
| infant | 0 / 23620 | 0 | |
| juvenile | 1 / 55556 | 17 | |
| adult | 51 / 1939121 | 26 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 0 / 17475 | 0 | |
| breast (mammary gland) tumor | 0 / 94178 | 0 | |
| cervical tumor | 0 / 34366 | 0 | |
| chondrosarcoma | 3 / 82823 | 36 | |
| colorectal tumor | 1 / 114246 | 8 |  |
| esophageal tumor | 0 / 17290 | 0 | |
| gastrointestinal tumor | 1 / 119369 | 8 | |
| germ cell tumor | 10 / 263845 | 37 | |
| glioma | 2 / 106883 | 18 | |
| head and neck tumor | 0 / 136302 | 0 | |
| kidney tumor | 2 / 68959 | 29 | |
| leukemia | 0 / 95842 | 0 | |
| liver tumor | 1 / 96359 | 10 | |
| lung tumor | 0 / 103127 | 0 | |
| lymphoma | 0 / 71755 | 0 | |
| non-neoplasia | 3 / 97250 | 30 | |
| normal | 87 / 3360307 | 25 | |
| ovarian tumor | 0 / 76682 | 0 | |
| pancreatic tumor | 1 / 104616 | 9 | |
| primitive neuroectodermal tumor of the CNS | 4 / 125680 | 31 | |
| prostate cancer | 0 / 102680 | 0 | |
| retinoblastoma | 0 / 46356 | 0 | |
| skin tumor | 0 / 124949 | 0 | |
| soft tissue/muscle tissue tumor | 11 / 125191 | 87 |  |
| uterine tumor | 1 / 90257 | 11 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 0 / 13106 | 0 | |
| adrenal gland | 0 / 33197 | 0 | |
| ascites | 0 / 40015 | 0 | |
| bladder | 0 / 29757 | 0 | |
| blood | 2 / 123478 | 16 | |
| bone | 2 / 71655 | 27 | |
| bone marrow | 0 / 48801 | 0 | |
| brain | 42 / 1100989 | 38 | |
| cervix | 0 / 48171 | 0 | |
| connective tissue | 14 / 149255 | 93 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 1 / 215722 | 4 | |
| esophagus | 0 / 20209 | 0 | |
| eye | 2 / 211054 | 9 | |
| heart | 0 / 89626 | 0 | |
| intestine | 4 / 234472 | 17 | |
| kidney | 16 / 211777 | 75 | |
| larynx | 0 / 24145 | 0 | |
| liver | 2 / 207743 | 9 | |
| lung | 1 / 336974 | 2 | |
| lymph | 0 / 44270 | 0 | |
| lymph node | 0 / 91610 | 0 | |
| mammary gland | 3 / 153271 | 19 | |
| mouth | 0 / 67052 | 0 | |
| muscle | 2 / 107715 | 18 | |
| nerve | 0 / 15768 | 0 | |
| ovary | 1 / 102051 | 9 | |
| pancreas | 2 / 214812 | 9 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 0 / 41328 | 0 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 0 / 280825 | 0 | |
| prostate | 1 / 189345 | 5 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 1 / 210574 | 4 | |
| spleen | 0 / 53952 | 0 | |
| stomach | 1 / 96619 | 10 | |
| testis | 5 / 330442 | 15 | |
| thymus | 0 / 81131 | 0 | |
| thyroid | 0 / 47473 | 0 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 0 / 52413 | 0 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 1 / 232878 | 4 | |
| vascular | 2 / 51780 | 38 | |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 208230_s_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 5.6 | |
| Adipocyte | 4.7 | |
| AdrenalCortex | 5.1 | |
| Adrenalgland | 4.2 | |
| Amygdala | 5 | |
| Appendix | 5 | |
| AtrioventricularNode | 4.35 | |
| BDCA4+_DentriticCells | 4.85 | |
| Bonemarrow | 4.85 | |
| BronchialEpithelialCells | 4.75 | |
| CD105+_Endothelial | 4.75 | |
| CD14+_Monocytes | 5.25 | |
| CD19+_BCells(neg._sel.) | 5 | |
| CD33+_Myeloid | 6.15 | |
| CD34+ | 5.95 | |
| CD4+_Tcells | 5 | |
| CD56+_NKCells | 5.35 | |
| CD71+_EarlyErythroid | 4.4 | |
| CD8+_Tcells | 4.3 | |
| CardiacMyocytes | 7.9 | |
| Caudatenucleus | 4.25 | |
| Cerebellum | 4 | |
| CerebellumPeduncles | 6.25 | |
| CiliaryGanglion | 3.9 | |
| CingulateCortex | 4.85 | |
| Colorectaladenocarcinoma | 4.75 | |
| DorsalRootGanglion | 4.35 | |
| FetalThyroid | 4.6 | |
| Fetalbrain | 4.65 | |
| Fetalliver | 4.15 | |
| Fetallung | 3.8 | |
| GlobusPallidus | 3.9 | |
| Heart | 6.7 | |
| Hypothalamus | 5 | |
| Kidney | 4.2 | |
| Leukemia_chronicMyelogenousK-562 | 4.3 | |
| Leukemia_promyelocytic-HL-60 | 4.15 | |
| Leukemialymphoblastic(MOLT-4) | 4.05 | |
| Liver | 6.7 | |
| Lung | 5.15 | |
| Lymphnode | 4.05 | |
| Lymphoma_burkitts(Daudi) | 6.1 | |
| Lymphoma_burkitts(Raji) | 6.8 | |
| MedullaOblongata | 4.35 | |
| OccipitalLobe | 4.2 | |
| OlfactoryBulb | 3.7 | |
| Ovary | 3.2 | |
| Pancreas | 4.4 | |
| PancreaticIslet | 5.25 | |
| ParietalLobe | 5.8 | |
| Pituitary | 6.35 | |
| Placenta | 4.7 | |
| Pons | 5.2 | |
| PrefrontalCortex | 5.85 | |
| Prostate | 5.85 | |
| Salivarygland | 3.8 | |
| SkeletalMuscle | 6.25 | |
| Skin | 3.75 | |
| SmoothMuscle | 5.55 | |
| Spinalcord | 5.1 | |
| SubthalamicNucleus | 4.25 | |
| SuperiorCervicalGanglion | 5.75 | |
| TemporalLobe | 4.3 | |
| Testis | 4.15 | |
| TestisGermCell | 4.4 | |
| TestisIntersitial | 4.1 | |
| TestisLeydigCell | 5.75 | |
| TestisSeminiferousTubule | 4.05 | |
| Thalamus | 4.75 | |
| Thymus | 3.7 | |
| Thyroid | 5.9 | |
| Tongue | 5 | |
| Tonsil | 4.65 | |
| Trachea | 3.95 | |
| TrigeminalGanglion | 5.35 | |
| Uterus | 3.85 | |
| UterusCorpus | 5.8 | |
| WholeBlood | 5.25 | |
| Wholebrain | 3.95 | |
| colon | 4.75 | |
| pineal_day | 6 | |
| pineal_night | 5.76 | |
| retina | 5.725 | |
| small_intestine | 4.55 | |
- Probe name: CUST_16945_PI416261804
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 3.23 ± 0.9 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 2.47 ± 0.2 | |
| Basal Part of Pons | 3.1 ± 0.62 | |
| Cerebellar Cortex | 2.78 ± 0.67 | |
| Cerebellar Nuclei | 3 ± 0.58 | |
| Claustrum | 3.27 ± 0.66 | |
| Epithalamus | 2.57 ± 0.73 | |
| Frontal Lobe | 3.11 ± 0.64 | |
| Globus Pallidus | 3.06 ± 0.78 | |
| Hypothalamus | 3.26 ± 0.6 | |
| Insula | 3.08 ± 0.61 | |
| Limbic Lobe | 2.73 ± 0.64 | |
| Mesencephalon | 2.89 ± 0.8 | |
| Myelencephalon | 2.87 ± 0.63 | |
| Occipital Lobe | 2.62 ± 0.83 | |
| Parietal Lobe | 2.85 ± 0.66 | |
| Pontine Tegmentum | 2.94 ± 0.67 | |
| Striatum | 2.32 ± 0.63 | |
| Subthalamus | 2.8 ± 0.63 | |
| Temporal Lobe | 2.74 ± 0.7 | |
| Thalamus | 2.92 ± 0.61 | |
| White Matter | 2.27 ± 0.41 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Nrg1 | CB | Cerebellum | 17.89 | |
| 29.55 | | |||
| Nrg1 | CTX | Cerebral cortex | 5.33 | |
| 3.84 | | |||
| Nrg1 | HIP | Hippocampal region | 0.6 | |
| 0.71 | | |||
| Nrg1 | HPF | Hippocampal formation | 1.46 | |
| 1.42 | | |||
| Nrg1 | HY | Hypothalamus | 5.47 | |
| 5.35 | | |||
| Nrg1 | LSX | Lateral septal complex | 1.18 | |
| 1.19 | | |||
| Nrg1 | MB | Midbrain | 12.94 | |
| 16.12 | | |||
| Nrg1 | MY | Medulla | 31.25 | |
| 52.4 | | |||
| Nrg1 | OLF | Olfactory bulb | 7.03 | |
| 6.13 | | |||
| Nrg1 | P | Pons | 28.23 | |
| 39.36 | | |||
| Nrg1 | PAL | Pallidum | 10.15 | |
| 12.08 | | |||
| Nrg1 | RHP | Retrohippocampal region | 2.6 | |
| 2.2 | | |||
| Nrg1 | sAMY | Striatum-like amygdalar nuclei | 3.99 | |
| 4 | | |||
| Nrg1 | STR | Striatum | 4.29 | |
| 3.21 | | |||
| Nrg1 | STRd | Striatum dorsal region | 5.33 | |
| 3.84 | | |||
| Nrg1 | STRv | Striatum ventral region | 2.24 | |
| 1.81 | | |||
| Nrg1 | TH | Thalamus | 5.04 | |
| 5.07 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| NRG1_HUMAN_22 | 16 | 22 | 37 | KPESAAGSQSPALPPR | PRIDE |
| PAp00009445 | 11 | 57 | 67 | CETSSEYSSLR | Peptide Atlas |