AutismKB 2.0

Annotation Detail for UBE2K


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Basic Information Top
Gene Symbol:UBE2K ( DKFZp564C1216,DKFZp686J24237,E2-25K,HIP2,HYPG,LIG )
Gene Full Name: ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)
Band: 4p14
Quick LinksEntrez ID:3093; OMIM: 602846; Uniprot ID:UBE2K_HUMAN; ENSEMBL ID: ENSG00000078140; HGNC ID: 4914
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202346_at
Cell line Expression level Expression bar
721_B_lymphoblasts47.25
Adipocyte7.8
AdrenalCortex9.75
Adrenalgland7.3
Amygdala34.6
Appendix9.6
AtrioventricularNode6.9
BDCA4+_DentriticCells56.15
Bonemarrow8.3
BronchialEpithelialCells12
CD105+_Endothelial32.2
CD14+_Monocytes8.9
CD19+_BCells(neg._sel.)9.15
CD33+_Myeloid29.45
CD34+22.8
CD4+_Tcells8
CD56+_NKCells13.65
CD71+_EarlyErythroid44.3
CD8+_Tcells7.7
CardiacMyocytes11.8
Caudatenucleus7.4
Cerebellum6.95
CerebellumPeduncles9.4
CiliaryGanglion6.95
CingulateCortex9.2
Colorectaladenocarcinoma8.15
DorsalRootGanglion6.5
FetalThyroid7.25
Fetalbrain14.1
Fetalliver21.15
Fetallung6.05
GlobusPallidus6
Heart11.1
Hypothalamus10.8
Kidney6.75
Leukemia_chronicMyelogenousK-5627.25
Leukemia_promyelocytic-HL-6012
Leukemialymphoblastic(MOLT-4)8.45
Liver11
Lung7.7
Lymphnode5.65
Lymphoma_burkitts(Daudi)10.9
Lymphoma_burkitts(Raji)11.65
MedullaOblongata7.25
OccipitalLobe16.95
OlfactoryBulb6.1
Ovary5.25
Pancreas6.4
PancreaticIslet8.6
ParietalLobe9.05
Pituitary9.7
Placenta9.45
Pons8.8
PrefrontalCortex14.6
Prostate12.5
Salivarygland6.6
SkeletalMuscle11.95
Skin6.6
SmoothMuscle9.2
Spinalcord8.65
SubthalamicNucleus8.05
SuperiorCervicalGanglion10.1
TemporalLobe7.8
Testis6.15
TestisGermCell6.3
TestisIntersitial7.2
TestisLeydigCell8.1
TestisSeminiferousTubule6.1
Thalamus8.4
Thymus6
Thyroid10.25
Tongue8.95
Tonsil8.15
Trachea6.75
TrigeminalGanglion8.95
Uterus10.25
UterusCorpus7.45
WholeBlood16.25
Wholebrain18.4
colon74.7
pineal_day16.96
pineal_night20.64
retina12.575
small_intestine35.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P155677
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.34 ± 0.61
Basal Forebrain8.52 ± 0.12
Basal Part of Pons8.98 ± 0.19
Cerebellar Cortex8.77 ± 0.17
Cerebellar Nuclei8.58 ± 0.35
Claustrum8.55 ± 0.39
Epithalamus8.29 ± 0.23
Frontal Lobe8.81 ± 0.3
Globus Pallidus7.98 ± 0.26
Hypothalamus8.82 ± 0.26
Insula8.87 ± 0.21
Limbic Lobe8.69 ± 0.51
Mesencephalon8.6 ± 0.49
Myelencephalon8.58 ± 0.48
Occipital Lobe8.4 ± 0.54
Parietal Lobe8.75 ± 0.31
Pontine Tegmentum8.56 ± 0.36
Striatum7.96 ± 0.43
Subthalamus8.96 ± 0.24
Temporal Lobe8.81 ± 0.27
Thalamus8.59 ± 0.35
White Matter7.65 ± 0.21
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Hip2CBCerebellum51.76
99.14
Hip2CTXCerebral cortex100
100
Hip2HIPHippocampal region100
100
Hip2HPFHippocampal formation100
100
Hip2HYHypothalamus94.59
95.73
Hip2LSXLateral septal complex100
100
Hip2MBMidbrain84.66
96.17
Hip2MYMedulla61.63
80.99
Hip2OLFOlfactory bulb100
100
Hip2PPons60.72
87.41
Hip2PALPallidum95.4
100
Hip2RHPRetrohippocampal region100
100
Hip2sAMYStriatum-like amygdalar nuclei96.81
92.73
Hip2STRStriatum98
94.07
Hip2STRdStriatum dorsal region91.95
86.19
Hip2STRvStriatum ventral region100
100
Hip2THThalamus93.47
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00004351 12 165 176 KIENLCAMGFDR Peptide Atlas
UBE2K_HUMAN_0 0 0 0 GEIAGPPDTPYEGGR PRIDE
UBE2K_HUMAN_1 7 1 7 ANIAVQR PRIDE
UBE2K_HUMAN_107 28 107 134 TVLLSLQALLAAAEPDDPQDAVVANQYK PRIDE
UBE2K_HUMAN_135 7 135 141 QNPEMFK PRIDE
UBE2K_HUMAN_146 18 146 163 LWAHVYAGAPVSSPEYTK PRIDE
UBE2K_HUMAN_164 12 164 175 KIENLCAMGFDR PRIDE
UBE2K_HUMAN_176 10 176 185 NAVIVALSSK PRIDE
UBE2K_HUMAN_2 7 2 8 ANIAVQR PRIDE
UBE2K_HUMAN_40 15 40 54 GEIAGPPDTPYEGGR PRIDE
UBE2K_HUMAN_55 19 55 73 YQLEIKIPETYPFNPPKVR PRIDE
UBE2K_HUMAN_78 19 78 96 IWHPNISSVTGAICLDILK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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