AutismKB 2.0

Annotation Detail for HINT1


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Basic Information Top
Gene Symbol:HINT1 ( FLJ30414,FLJ32340,HINT,PKCI-1,PRKCNH1 )
Gene Full Name: histidine triad nucleotide binding protein 1
Band: 5q23.3
Quick LinksEntrez ID:3094; OMIM: 601314; Uniprot ID:HINT1_HUMAN; ENSEMBL ID: ENSG00000169567; HGNC ID: 4912
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body10 / 70761141
blastocyst2 / 6231932
fetus98 / 564012173
neonate1 / 3109732
infant2 / 2362084
juvenile2 / 5555635
adult254 / 1939121130
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor5 / 12794390
bladder carcinoma8 / 17475457
breast (mammary gland) tumor17 / 94178180
cervical tumor2 / 3436658
chondrosarcoma5 / 8282360
colorectal tumor17 / 114246148
esophageal tumor2 / 17290115
gastrointestinal tumor15 / 119369125
germ cell tumor26 / 26384598
glioma23 / 106883215
head and neck tumor37 / 136302271
kidney tumor10 / 68959145
leukemia12 / 95842125
liver tumor10 / 96359103
lung tumor10 / 10312796
lymphoma3 / 7175541
non-neoplasia9 / 9725092
normal426 / 3360307126
ovarian tumor12 / 76682156
pancreatic tumor10 / 10461695
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer33 / 102680321
retinoblastoma3 / 4635664
skin tumor8 / 12494964
soft tissue/muscle tissue tumor20 / 125191159
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland5 / 33197150
ascites6 / 40015149
bladder12 / 29757403
blood27 / 123478218
bone8 / 71655111
bone marrow18 / 48801368
brain122 / 1100989110
cervix3 / 4817162
connective tissue15 / 149255100
ear0 / 162120 
embryonic tissue25 / 215722115
esophagus2 / 2020998
eye24 / 211054113
heart35 / 89626390
intestine24 / 234472102
kidney21 / 21177799
larynx0 / 241450 
liver48 / 207743231
lung37 / 336974109
lymph2 / 4427045
lymph node8 / 9161087
mammary gland20 / 153271130
mouth35 / 67052521
muscle12 / 107715111
nerve0 / 157680 
ovary17 / 102051166
pancreas31 / 214812144
parathyroid2 / 2053997
pharynx5 / 41328120
pituitary gland1 / 1658560
placenta24 / 28082585
prostate42 / 189345221
salivary gland9 / 20155446
skin22 / 210574104
spleen2 / 5395237
stomach7 / 9661972
testis28 / 33044284
thymus4 / 8113149
thyroid1 / 4747321
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord1 / 1368073
uterus15 / 23287864
vascular7 / 51780135
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208826_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts3120.55
Adipocyte847.9
AdrenalCortex365.6
Adrenalgland611.6
Amygdala1366.9
Appendix302.1
AtrioventricularNode106.9
BDCA4+_DentriticCells2310.2
Bonemarrow744.15
BronchialEpithelialCells2908.1
CD105+_Endothelial1820.65
CD14+_Monocytes1252.15
CD19+_BCells(neg._sel.)3154.3
CD33+_Myeloid1381.6
CD34+4607.15
CD4+_Tcells2379.15
CD56+_NKCells1836.8
CD71+_EarlyErythroid788.95
CD8+_Tcells1769.7
CardiacMyocytes840.8
Caudatenucleus1004.35
Cerebellum866.5
CerebellumPeduncles1317.65
CiliaryGanglion266
CingulateCortex1053.9
Colorectaladenocarcinoma911.95
DorsalRootGanglion436.85
FetalThyroid1076.9
Fetalbrain945.3
Fetalliver827.1
Fetallung749
GlobusPallidus767.25
Heart963.45
Hypothalamus1718.85
Kidney928.8
Leukemia_chronicMyelogenousK-5621539.25
Leukemia_promyelocytic-HL-602093
Leukemialymphoblastic(MOLT-4)1836.9
Liver1514.7
Lung1136.25
Lymphnode831.85
Lymphoma_burkitts(Daudi)2153.95
Lymphoma_burkitts(Raji)1041.25
MedullaOblongata953.4
OccipitalLobe1290.5
OlfactoryBulb670.65
Ovary485.95
Pancreas710.15
PancreaticIslet1399.6
ParietalLobe1257.8
Pituitary1699.9
Placenta430.95
Pons721.85
PrefrontalCortex1068.2
Prostate1317.2
Salivarygland905.5
SkeletalMuscle213.25
Skin350.7
SmoothMuscle1455.95
Spinalcord985.1
SubthalamicNucleus1199.85
SuperiorCervicalGanglion128.25
TemporalLobe1414.65
Testis765.75
TestisGermCell693.8
TestisIntersitial867.4
TestisLeydigCell778.65
TestisSeminiferousTubule622.4
Thalamus1290.35
Thymus695.9
Thyroid1055.1
Tongue595.05
Tonsil1012.65
Trachea631
TrigeminalGanglion278.95
Uterus632.4
UterusCorpus440.55
WholeBlood829
Wholebrain2307.15
colon1015.35
pineal_day1469.8
pineal_night1518.22
retina1059.275
small_intestine734.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P47554
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala13.08 ± 0.41
Basal Forebrain13.08 ± 0.25
Basal Part of Pons13.93 ± 0.25
Cerebellar Cortex13.4 ± 0.3
Cerebellar Nuclei13.67 ± 0.29
Claustrum13.64 ± 0.54
Epithalamus13.03 ± 0.42
Frontal Lobe13.64 ± 0.36
Globus Pallidus13.05 ± 0.55
Hypothalamus13.88 ± 0.17
Insula13.7 ± 0.4
Limbic Lobe13.18 ± 0.69
Mesencephalon13.24 ± 0.53
Myelencephalon13.26 ± 0.61
Occipital Lobe12.58 ± 0.71
Parietal Lobe13.36 ± 0.47
Pontine Tegmentum13.34 ± 0.45
Striatum12.5 ± 0.57
Subthalamus13.99 ± 0.36
Temporal Lobe13.58 ± 0.4
Thalamus13.14 ± 0.43
White Matter12.88 ± 0.3
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Hint1CBCerebellum35.11
78.26
Hint1CTXCerebral cortex100
100
Hint1HIPHippocampal region73.77
100
Hint1HPFHippocampal formation86.43
100
Hint1HYHypothalamus83.12
87.49
Hint1LSXLateral septal complex80.97
76.55
Hint1MBMidbrain80.5
92.52
Hint1MYMedulla76.19
100
Hint1OLFOlfactory bulb90.8
100
Hint1PPons78.46
100
Hint1PALPallidum74.73
88.83
Hint1RHPRetrohippocampal region100
100
Hint1sAMYStriatum-like amygdalar nuclei77.34
76.37
Hint1STRStriatum39.17
38.51
Hint1STRdStriatum dorsal region28.23
28.59
Hint1STRvStriatum ventral region38.65
35.54
Hint1THThalamus86.48
89.48
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
HINT1_HUMAN_0 0 0 0 CLAFHDISPQAPTHFLVIPK PRIDE
HINT1_HUMAN_0 0 0 0 IIFEDDR PRIDE
HINT1_HUMAN_1 11 1 11 ADEIAKAQVAR PRIDE
HINT1_HUMAN_1 23 1 23 ADEIAKAQVARPGGDTIFGKIIR PRIDE
HINT1_HUMAN_12 12 12 23 PGGDTIFGKIIR PRIDE
HINT1_HUMAN_2 11 2 12 ADEIAKAQVAR PRIDE
HINT1_HUMAN_24 13 24 36 KEIPAKIIFEDDR PRIDE
HINT1_HUMAN_25 12 25 36 EIPAKIIFEDDR PRIDE
HINT1_HUMAN_25 13 25 37 KEIPAKIIFEDDR PRIDE
HINT1_HUMAN_30 27 30 56 IIFEDDRCLAFHDISPQAPTHFLVIPK PRIDE
HINT1_HUMAN_30 7 30 36 IIFEDDR PRIDE
HINT1_HUMAN_37 20 37 56 CLAFHDISPQAPTHFLVIPK PRIDE
HINT1_HUMAN_57 25 57 81 KHISQISVAEDDDESLLGHLMIVGK PRIDE
HINT1_HUMAN_57 26 57 82 KHISQISVAEDDDESLLGHLMIVGKK PRIDE
HINT1_HUMAN_58 24 58 81 HISQISVAEDDDESLLGHLMIVGK PRIDE
HINT1_HUMAN_58 25 58 82 HISQISVAEDDDESLLGHLMIVGKK PRIDE
HINT1_HUMAN_7 14 7 20 AQVARPGGDTIFGK PRIDE
HINT1_HUMAN_82 10 82 91 KCAADLGLNK PRIDE
HINT1_HUMAN_83 9 83 91 CAADLGLNK PRIDE
HINT1_HUMAN_95 24 95 118 MVVNEGSDGGQSVYHVHLHVLGGR PRIDE
PAp00000829 9 84 92 CAADLGLNK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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