AutismKB 2.0

Annotation Detail for HK1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:HK1 ( HK1-ta,HK1-tb,HK1-tc,HKI,HXK1 )
Gene Full Name: hexokinase 1
Band: 10q22.1
Quick LinksEntrez ID:3098; OMIM: 142600; Uniprot ID:HXK1_HUMAN; ENSEMBL ID: ENSG00000156515; HGNC ID: 4922
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body11 / 70761155
blastocyst17 / 62319272
fetus48 / 56401285
neonate1 / 3109732
infant1 / 2362042
juvenile4 / 5555671
adult285 / 1939121146
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor3 / 12794234
bladder carcinoma3 / 17475171
breast (mammary gland) tumor29 / 94178307
cervical tumor0 / 343660 
chondrosarcoma19 / 82823229
colorectal tumor17 / 114246148
esophageal tumor0 / 172900 
gastrointestinal tumor13 / 119369108
germ cell tumor20 / 26384575
glioma9 / 10688384
head and neck tumor14 / 136302102
kidney tumor9 / 68959130
leukemia12 / 95842125
liver tumor6 / 9635962
lung tumor19 / 103127184
lymphoma14 / 71755195
non-neoplasia12 / 97250123
normal342 / 3360307101
ovarian tumor9 / 76682117
pancreatic tumor8 / 10461676
primitive neuroectodermal tumor of the CNS27 / 125680214
prostate cancer7 / 10268068
retinoblastoma4 / 4635686
skin tumor11 / 12494988
soft tissue/muscle tissue tumor16 / 125191127
uterine tumor11 / 90257121
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland3 / 3319790
ascites10 / 40015249
bladder5 / 29757168
blood16 / 123478129
bone20 / 71655279
bone marrow3 / 4880161
brain97 / 110098988
cervix0 / 481710 
connective tissue9 / 14925560
ear1 / 1621261
embryonic tissue34 / 215722157
esophagus0 / 202090 
eye28 / 211054132
heart7 / 8962678
intestine34 / 234472145
kidney15 / 21177770
larynx5 / 24145207
liver13 / 20774362
lung69 / 336974204
lymph12 / 44270271
lymph node11 / 91610120
mammary gland43 / 153271280
mouth5 / 6705274
muscle4 / 10771537
nerve1 / 1576863
ovary10 / 10205197
pancreas8 / 21481237
parathyroid2 / 2053997
pharynx1 / 4132824
pituitary gland2 / 16585120
placenta22 / 28082578
prostate12 / 18934563
salivary gland0 / 201550 
skin53 / 210574251
spleen3 / 5395255
stomach2 / 9661920
testis46 / 330442139
thymus4 / 8113149
thyroid14 / 47473294
tonsil4 / 16999235
trachea0 / 524130 
umbilical cord1 / 1368073
uterus21 / 23287890
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 200697_at
Cell line Expression level Expression bar
721_B_lymphoblasts136.9
Adipocyte106.15
AdrenalCortex21.75
Adrenalgland29.85
Amygdala495.2
Appendix28.55
AtrioventricularNode22.35
BDCA4+_DentriticCells214.75
Bonemarrow234.1
BronchialEpithelialCells494
CD105+_Endothelial935.55
CD14+_Monocytes481.85
CD19+_BCells(neg._sel.)210.6
CD33+_Myeloid813.95
CD34+398.7
CD4+_Tcells280.3
CD56+_NKCells411.4
CD71+_EarlyErythroid1094.95
CD8+_Tcells190.35
CardiacMyocytes233.3
Caudatenucleus174.8
Cerebellum318.35
CerebellumPeduncles453.95
CiliaryGanglion42.5
CingulateCortex335.95
Colorectaladenocarcinoma79.7
DorsalRootGanglion59.2
FetalThyroid314.1
Fetalbrain239.4
Fetalliver267.25
Fetallung131.45
GlobusPallidus163.05
Heart198.8
Hypothalamus368.45
Kidney26.6
Leukemia_chronicMyelogenousK-562364.55
Leukemia_promyelocytic-HL-6017.3
Leukemialymphoblastic(MOLT-4)72.35
Liver26.1
Lung404.3
Lymphnode69.75
Lymphoma_burkitts(Daudi)9.8
Lymphoma_burkitts(Raji)121.95
MedullaOblongata213.2
OccipitalLobe293.35
OlfactoryBulb68.75
Ovary28
Pancreas39
PancreaticIslet35.65
ParietalLobe269.75
Pituitary145.05
Placenta182
Pons153.9
PrefrontalCortex567.35
Prostate522.8
Salivarygland74.15
SkeletalMuscle73.35
Skin70.5
SmoothMuscle310.4
Spinalcord83.1
SubthalamicNucleus270.85
SuperiorCervicalGanglion37.4
TemporalLobe241.2
Testis199.4
TestisGermCell177.95
TestisIntersitial274.1
TestisLeydigCell136.85
TestisSeminiferousTubule143.75
Thalamus176.95
Thymus168.7
Thyroid552.55
Tongue243.3
Tonsil88.35
Trachea52.6
TrigeminalGanglion58.45
Uterus92.25
UterusCorpus26.3
WholeBlood220.7
Wholebrain687.75
colon114.95
pineal_day559.38
pineal_night543.62
retina394.875
small_intestine41.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P102604
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.1 ± 0.85
Basal Forebrain2.18 ± 0.37
Basal Part of Pons3.02 ± 0.62
Cerebellar Cortex3.1 ± 0.62
Cerebellar Nuclei3.02 ± 0.46
Claustrum3.2 ± 0.69
Epithalamus2.34 ± 0.71
Frontal Lobe2.88 ± 0.68
Globus Pallidus2.4 ± 0.53
Hypothalamus2.92 ± 0.6
Insula3.31 ± 0.53
Limbic Lobe2.76 ± 0.58
Mesencephalon2.79 ± 0.76
Myelencephalon2.78 ± 0.67
Occipital Lobe2.73 ± 0.63
Parietal Lobe2.84 ± 0.63
Pontine Tegmentum2.77 ± 0.66
Striatum2.26 ± 0.74
Subthalamus3.09 ± 0.17
Temporal Lobe2.84 ± 0.69
Thalamus2.77 ± 0.67
White Matter2.06 ± 0.39
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Hk1CBCerebellum48.64
60.07
Hk1CTXCerebral cortex100
100
Hk1HIPHippocampal region100
100
Hk1HPFHippocampal formation100
100
Hk1HYHypothalamus97.45
97.57
Hk1LSXLateral septal complex92.69
83.61
Hk1MBMidbrain99.47
100
Hk1MYMedulla82.44
100
Hk1OLFOlfactory bulb98.48
100
Hk1PPons88.48
100
Hk1PALPallidum91.12
100
Hk1RHPRetrohippocampal region100
100
Hk1sAMYStriatum-like amygdalar nuclei89.69
86.01
Hk1STRStriatum59.08
52.56
Hk1STRdStriatum dorsal region48.33
42.59
Hk1STRvStriatum ventral region65.88
54.53
Hk1THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
HXK1_HUMAN_0 0 0 0 FKASGVEGADVVKLLNK PRIDE
HXK1_HUMAN_0 0 0 0 GAALITAVGVR PRIDE
HXK1_HUMAN_0 0 0 0 HIDLVEGDEGR PRIDE
HXK1_HUMAN_0 0 0 0 SANLVAATLGAILNR PRIDE
HXK1_HUMAN_295 12 295 306 MVSGMYLGELVR PRIDE
HXK1_HUMAN_296 12 296 307 MVSGMYLGELVR PRIDE
HXK1_HUMAN_30 12 30 41 LSDETLIDIMTR PRIDE
HXK1_HUMAN_381 15 381 395 SANLVAATLGAILNR PRIDE
HXK1_HUMAN_407 11 407 417 TTVGVDGSLYK PRIDE
HXK1_HUMAN_451 11 451 461 GAAMVTAVAYR PRIDE
HXK1_HUMAN_493 8 493 500 AEMELGLR PRIDE
HXK1_HUMAN_727 11 727 737 LVDEYSLNAGK PRIDE
HXK1_HUMAN_743 12 743 754 MISGMYLGEIVR PRIDE
HXK1_HUMAN_744 12 744 755 MISGMYLGEIVR PRIDE
HXK1_HUMAN_785 16 785 800 FLSQIESDRLALLQVR PRIDE
HXK1_HUMAN_899 11 899 909 GAALITAVGVR PRIDE
PAp00000723 14 624 637 ATDCVGHDVVTLLR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved