AutismKB 2.0

Annotation Detail for HK2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:HK2 ( DKFZp686M1669,HKII,HXK2 )
Gene Full Name: hexokinase 2
Band: 2p12
Quick LinksEntrez ID:3099; OMIM: 601125; Uniprot ID:HXK2_HUMAN; ENSEMBL ID: ENSG00000159399; HGNC ID: 4923
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus2 / 5640123
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult1 / 19391210 
embryoid body1 / 7076114
blastocyst4 / 6231964
fetus6 / 56401210
neonate0 / 310970 
infant0 / 236200 
juvenile5 / 5555689
adult112 / 193912157
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal4 / 33603071
ovarian tumor1 / 7668213
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor4 / 9417842
cervical tumor2 / 3436658
chondrosarcoma3 / 8282336
colorectal tumor4 / 11424635
esophageal tumor1 / 1729057
gastrointestinal tumor13 / 119369108
germ cell tumor26 / 26384598
glioma4 / 10688337
head and neck tumor18 / 136302132
kidney tumor4 / 6895958
leukemia16 / 95842166
liver tumor14 / 96359145
lung tumor4 / 10312738
lymphoma1 / 7175513
non-neoplasia4 / 9725041
normal99 / 336030729
ovarian tumor0 / 766820 
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer1 / 1026809
retinoblastoma4 / 4635686
skin tumor11 / 12494988
soft tissue/muscle tissue tumor7 / 12519155
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain0 / 11009890 
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary1 / 1020519
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta1 / 2808253
prostate0 / 1893450 
salivary gland0 / 201550 
skin1 / 2105744
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites6 / 40015149
bladder1 / 2975733
blood4 / 12347832
bone2 / 7165527
bone marrow11 / 48801225
brain15 / 110098913
cervix2 / 4817141
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue12 / 21572255
esophagus1 / 2020949
eye22 / 211054104
heart1 / 8962611
intestine17 / 23447272
kidney5 / 21177723
larynx5 / 24145207
liver17 / 20774381
lung19 / 33697456
lymph1 / 4427022
lymph node4 / 9161043
mammary gland7 / 15327145
mouth13 / 67052193
muscle9 / 10771583
nerve0 / 157680 
ovary4 / 10205139
pancreas3 / 21481213
parathyroid1 / 2053948
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta8 / 28082528
prostate3 / 18934515
salivary gland0 / 201550 
skin17 / 21057480
spleen0 / 539520 
stomach7 / 9661972
testis33 / 33044299
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus13 / 23287855
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202934_at
Cell line Expression level Expression bar
721_B_lymphoblasts256.05
Adipocyte140.4
AdrenalCortex9.4
Adrenalgland7.25
Amygdala6.95
Appendix8.75
AtrioventricularNode20.5
BDCA4+_DentriticCells47.8
Bonemarrow35.8
BronchialEpithelialCells68.5
CD105+_Endothelial9.4
CD14+_Monocytes339.55
CD19+_BCells(neg._sel.)31.5
CD33+_Myeloid417.1
CD34+58.35
CD4+_Tcells8.3
CD56+_NKCells19.05
CD71+_EarlyErythroid9.5
CD8+_Tcells6.65
CardiacMyocytes40.5
Caudatenucleus7.25
Cerebellum6.45
CerebellumPeduncles8.65
CiliaryGanglion20.25
CingulateCortex9.1
Colorectaladenocarcinoma7.25
DorsalRootGanglion10.15
FetalThyroid9.35
Fetalbrain6.95
Fetalliver5.85
Fetallung9.2
GlobusPallidus7.65
Heart10.5
Hypothalamus9.2
Kidney6.45
Leukemia_chronicMyelogenousK-56212.3
Leukemia_promyelocytic-HL-6083.45
Leukemialymphoblastic(MOLT-4)15.85
Liver10.25
Lung12.9
Lymphnode8.1
Lymphoma_burkitts(Daudi)48.6
Lymphoma_burkitts(Raji)33.75
MedullaOblongata6.35
OccipitalLobe6.8
OlfactoryBulb6.6
Ovary24.55
Pancreas65.9
PancreaticIslet8.1
ParietalLobe8.75
Pituitary8.2
Placenta25.05
Pons8.15
PrefrontalCortex7.25
Prostate9.2
Salivarygland7.45
SkeletalMuscle79
Skin13.75
SmoothMuscle51.45
Spinalcord22.35
SubthalamicNucleus8.9
SuperiorCervicalGanglion9.15
TemporalLobe7.85
Testis71.3
TestisGermCell142.2
TestisIntersitial38.35
TestisLeydigCell41.3
TestisSeminiferousTubule96.55
Thalamus9.6
Thymus5.95
Thyroid16.45
Tongue37.65
Tonsil8.95
Trachea21.55
TrigeminalGanglion13.65
Uterus3.8
UterusCorpus8.35
WholeBlood103.05
Wholebrain5.85
colon230.7
pineal_day9.28
pineal_night8.98
retina82.325
small_intestine4.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P398460
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.31 ± 0.7
Basal Forebrain4.58 ± 0.34
Basal Part of Pons4.66 ± 0.49
Cerebellar Cortex4.01 ± 0.58
Cerebellar Nuclei5.68 ± 0.47
Claustrum4.22 ± 0.68
Epithalamus5.9 ± 0.43
Frontal Lobe4.16 ± 0.78
Globus Pallidus6.71 ± 0.37
Hypothalamus5.18 ± 0.98
Insula4.02 ± 0.68
Limbic Lobe4.06 ± 0.97
Mesencephalon4.52 ± 0.85
Myelencephalon4.48 ± 0.74
Occipital Lobe3.83 ± 0.95
Parietal Lobe4.26 ± 0.81
Pontine Tegmentum4.21 ± 0.69
Striatum4.91 ± 0.75
Subthalamus5.02 ± 0.21
Temporal Lobe4.39 ± 0.71
Thalamus4.34 ± 0.72
White Matter6.53 ± 0.45
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Hk2CBCerebellum13.37
18.88
Hk2CTXCerebral cortex2.56
2.89
Hk2HIPHippocampal region2.19
3.17
Hk2HPFHippocampal formation1.91
2.68
Hk2HYHypothalamus0.77
1.14
Hk2LSXLateral septal complex0.66
1.01
Hk2MBMidbrain1.13
2.21
Hk2MYMedulla3.19
3.96
Hk2OLFOlfactory bulb3.38
3.28
Hk2PPons1.56
2.46
Hk2PALPallidum1.3
1.46
Hk2RHPRetrohippocampal region1.33
1.95
Hk2sAMYStriatum-like amygdalar nuclei1.06
1.19
Hk2STRStriatum1.32
1.48
Hk2STRdStriatum dorsal region1.18
1.4
Hk2STRvStriatum ventral region2.1
2.01
Hk2THThalamus3.41
4.8
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
HXK2_HUMAN_0 0 0 0 GDFLALDLGGTNFR PRIDE
HXK2_HUMAN_525 14 525 538 GDFLALDLGGTNFR PRIDE
PAp00004923 15 359 373 LGLDPTQEDCVATHR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved