Annotation Detail for HLA-B
Basic Information Top
| Gene Symbol: | HLA-B ( AS,HLA-B27,HLA-B73,HLAB,MGC111087,SPDA1 ) |
|---|---|
| Gene Full Name: | major histocompatibility complex, class I, B |
| Band: | 6p21.33 |
| Quick Links | Entrez ID:3106; OMIM: 142830; Uniprot ID:1B07_HUMAN; ENSEMBL ID: ENSG00000234745; HGNC ID: 4932 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.703277
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 2 / 70761 | 28 |  |
| blastocyst | 1 / 62319 | 16 | |
| fetus | 78 / 564012 | 138 |  |
| neonate | 52 / 31097 | 1672 |  |
| infant | 1 / 23620 | 42 | |
| juvenile | 22 / 55556 | 395 |  |
| adult | 2203 / 1939121 | 1136 | |
| embryoid body | 19 / 70761 | 268 | |
| blastocyst | 20 / 62319 | 320 | |
| fetus | 64 / 564012 | 113 | |
| neonate | 61 / 31097 | 1961 | |
| infant | 3 / 23620 | 127 | |
| juvenile | 33 / 55556 | 593 | |
| adult | 1757 / 1939121 | 906 | |
| embryoid body | 0 / 70761 | 0 | |
| blastocyst | 0 / 62319 | 0 | |
| fetus | 0 / 564012 | 0 | |
| neonate | 0 / 31097 | 0 | |
| infant | 0 / 23620 | 0 | |
| juvenile | 0 / 55556 | 0 | |
| adult | 1 / 1939121 | 0 |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 10 / 12794 | 781 | |
| bladder carcinoma | 9 / 17475 | 515 | |
| breast (mammary gland) tumor | 32 / 94178 | 339 | |
| cervical tumor | 57 / 34366 | 1658 | |
| chondrosarcoma | 28 / 82823 | 338 | |
| colorectal tumor | 186 / 114246 | 1628 | |
| esophageal tumor | 19 / 17290 | 1098 | |
| gastrointestinal tumor | 181 / 119369 | 1516 | |
| germ cell tumor | 30 / 263845 | 113 | |
| glioma | 64 / 106883 | 598 | |
| head and neck tumor | 167 / 136302 | 1225 | |
| kidney tumor | 31 / 68959 | 449 | |
| leukemia | 82 / 95842 | 855 | |
| liver tumor | 89 / 96359 | 923 | |
| lung tumor | 337 / 103127 | 3267 | |
| lymphoma | 110 / 71755 | 1532 | |
| non-neoplasia | 238 / 97250 | 2447 | |
| normal | 2492 / 3360307 | 741 | |
| ovarian tumor | 39 / 76682 | 508 | |
| pancreatic tumor | 126 / 104616 | 1204 | |
| primitive neuroectodermal tumor of the CNS | 6 / 125680 | 47 | |
| prostate cancer | 20 / 102680 | 194 | |
| retinoblastoma | 1 / 46356 | 21 | |
| skin tumor | 53 / 124949 | 424 | |
| soft tissue/muscle tissue tumor | 11 / 125191 | 87 | |
| uterine tumor | 286 / 90257 | 3168 | |
| adrenal tumor | 10 / 12794 | 781 | |
| bladder carcinoma | 10 / 17475 | 572 | |
| breast (mammary gland) tumor | 52 / 94178 | 552 | |
| cervical tumor | 69 / 34366 | 2007 | |
| chondrosarcoma | 30 / 82823 | 362 | |
| colorectal tumor | 140 / 114246 | 1225 | |
| esophageal tumor | 6 / 17290 | 347 | |
| gastrointestinal tumor | 125 / 119369 | 1047 | |
| germ cell tumor | 50 / 263845 | 189 | |
| glioma | 44 / 106883 | 411 | |
| head and neck tumor | 128 / 136302 | 939 | |
| kidney tumor | 28 / 68959 | 406 | |
| leukemia | 57 / 95842 | 594 | |
| liver tumor | 148 / 96359 | 1535 | |
| lung tumor | 122 / 103127 | 1183 | |
| lymphoma | 66 / 71755 | 919 | |
| non-neoplasia | 130 / 97250 | 1336 | |
| normal | 2283 / 3360307 | 679 | |
| ovarian tumor | 70 / 76682 | 912 | |
| pancreatic tumor | 126 / 104616 | 1204 | |
| primitive neuroectodermal tumor of the CNS | 27 / 125680 | 214 | |
| prostate cancer | 47 / 102680 | 457 | |
| retinoblastoma | 0 / 46356 | 0 | |
| skin tumor | 52 / 124949 | 416 | |
| soft tissue/muscle tissue tumor | 12 / 125191 | 95 | |
| uterine tumor | 111 / 90257 | 1229 | |
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 0 / 17475 | 0 | |
| breast (mammary gland) tumor | 0 / 94178 | 0 | |
| cervical tumor | 0 / 34366 | 0 | |
| chondrosarcoma | 0 / 82823 | 0 | |
| colorectal tumor | 0 / 114246 | 0 | |
| esophageal tumor | 0 / 17290 | 0 | |
| gastrointestinal tumor | 0 / 119369 | 0 | |
| germ cell tumor | 0 / 263845 | 0 | |
| glioma | 0 / 106883 | 0 | |
| head and neck tumor | 0 / 136302 | 0 | |
| kidney tumor | 0 / 68959 | 0 | |
| leukemia | 0 / 95842 | 0 | |
| liver tumor | 0 / 96359 | 0 | |
| lung tumor | 0 / 103127 | 0 | |
| lymphoma | 0 / 71755 | 0 | |
| non-neoplasia | 0 / 97250 | 0 | |
| normal | 1 / 3360307 | 0 | |
| ovarian tumor | 0 / 76682 | 0 | |
| pancreatic tumor | 0 / 104616 | 0 | |
| primitive neuroectodermal tumor of the CNS | 0 / 125680 | 0 | |
| prostate cancer | 0 / 102680 | 0 | |
| retinoblastoma | 0 / 46356 | 0 | |
| skin tumor | 0 / 124949 | 0 | |
| soft tissue/muscle tissue tumor | 0 / 125191 | 0 | |
| uterine tumor | 0 / 90257 | 0 |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 25 / 13106 | 1907 | |
| adrenal gland | 27 / 33197 | 813 | |
| ascites | 32 / 40015 | 799 | |
| bladder | 13 / 29757 | 436 | |
| blood | 205 / 123478 | 1660 | |
| bone | 36 / 71655 | 502 | |
| bone marrow | 30 / 48801 | 614 | |
| brain | 269 / 1100989 | 244 | |
| cervix | 62 / 48171 | 1287 | |
| connective tissue | 223 / 149255 | 1494 | |
| ear | 3 / 16212 | 185 | |
| embryonic tissue | 6 / 215722 | 27 | |
| esophagus | 25 / 20209 | 1237 | |
| eye | 58 / 211054 | 274 | |
| heart | 34 / 89626 | 379 | |
| intestine | 544 / 234472 | 2320 | |
| kidney | 47 / 211777 | 221 | |
| larynx | 51 / 24145 | 2112 | |
| liver | 136 / 207743 | 654 | |
| lung | 557 / 336974 | 1652 | |
| lymph | 33 / 44270 | 745 | |
| lymph node | 118 / 91610 | 1288 | |
| mammary gland | 62 / 153271 | 404 | |
| mouth | 62 / 67052 | 924 | |
| muscle | 22 / 107715 | 204 | |
| nerve | 12 / 15768 | 761 | |
| ovary | 67 / 102051 | 656 | |
| pancreas | 230 / 214812 | 1070 | |
| parathyroid | 5 / 20539 | 243 | |
| pharynx | 29 / 41328 | 701 | |
| pituitary gland | 14 / 16585 | 844 | |
| placenta | 187 / 280825 | 665 | |
| prostate | 53 / 189345 | 279 | |
| salivary gland | 6 / 20155 | 297 | |
| skin | 123 / 210574 | 584 | |
| spleen | 216 / 53952 | 4003 | |
| stomach | 207 / 96619 | 2142 | |
| testis | 34 / 330442 | 102 | |
| thymus | 50 / 81131 | 616 | |
| thyroid | 58 / 47473 | 1221 | |
| tonsil | 26 / 16999 | 1529 | |
| trachea | 11 / 52413 | 209 | |
| umbilical cord | 2 / 13680 | 146 | |
| uterus | 359 / 232878 | 1541 | |
| vascular | 21 / 51780 | 405 | |
| adipose tissue | 21 / 13106 | 1602 | |
| adrenal gland | 24 / 33197 | 722 | |
| ascites | 37 / 40015 | 924 | |
| bladder | 16 / 29757 | 537 | |
| blood | 169 / 123478 | 1368 | |
| bone | 33 / 71655 | 460 | |
| bone marrow | 28 / 48801 | 573 | |
| brain | 380 / 1100989 | 345 | |
| cervix | 77 / 48171 | 1598 | |
| connective tissue | 87 / 149255 | 582 | |
| ear | 1 / 16212 | 61 | |
| embryonic tissue | 56 / 215722 | 259 | |
| esophagus | 14 / 20209 | 692 | |
| eye | 70 / 211054 | 331 | |
| heart | 61 / 89626 | 680 | |
| intestine | 404 / 234472 | 1723 | |
| kidney | 46 / 211777 | 217 | |
| larynx | 43 / 24145 | 1780 | |
| liver | 175 / 207743 | 842 | |
| lung | 314 / 336974 | 931 | |
| lymph | 35 / 44270 | 790 | |
| lymph node | 42 / 91610 | 458 | |
| mammary gland | 67 / 153271 | 437 | |
| mouth | 58 / 67052 | 865 | |
| muscle | 27 / 107715 | 250 | |
| nerve | 14 / 15768 | 887 | |
| ovary | 88 / 102051 | 862 | |
| pancreas | 182 / 214812 | 847 | |
| parathyroid | 8 / 20539 | 389 | |
| pharynx | 11 / 41328 | 266 | |
| pituitary gland | 11 / 16585 | 663 | |
| placenta | 153 / 280825 | 544 | |
| prostate | 88 / 189345 | 464 | |
| salivary gland | 11 / 20155 | 545 | |
| skin | 99 / 210574 | 470 | |
| spleen | 139 / 53952 | 2576 | |
| stomach | 144 / 96619 | 1490 | |
| testis | 66 / 330442 | 199 | |
| thymus | 77 / 81131 | 949 | |
| thyroid | 42 / 47473 | 884 | |
| tonsil | 22 / 16999 | 1294 | |
| trachea | 8 / 52413 | 152 | |
| umbilical cord | 2 / 13680 | 146 | |
| uterus | 202 / 232878 | 867 | |
| vascular | 23 / 51780 | 444 | |
| adipose tissue | 0 / 13106 | 0 | |
| adrenal gland | 0 / 33197 | 0 | |
| ascites | 0 / 40015 | 0 | |
| bladder | 0 / 29757 | 0 | |
| blood | 0 / 123478 | 0 | |
| bone | 0 / 71655 | 0 | |
| bone marrow | 0 / 48801 | 0 | |
| brain | 0 / 1100989 | 0 | |
| cervix | 0 / 48171 | 0 | |
| connective tissue | 0 / 149255 | 0 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 0 / 215722 | 0 | |
| esophagus | 0 / 20209 | 0 | |
| eye | 0 / 211054 | 0 | |
| heart | 0 / 89626 | 0 | |
| intestine | 1 / 234472 | 4 |  |
| kidney | 0 / 211777 | 0 | |
| larynx | 0 / 24145 | 0 | |
| liver | 0 / 207743 | 0 | |
| lung | 1 / 336974 | 2 | |
| lymph | 0 / 44270 | 0 | |
| lymph node | 0 / 91610 | 0 | |
| mammary gland | 0 / 153271 | 0 | |
| mouth | 0 / 67052 | 0 | |
| muscle | 0 / 107715 | 0 | |
| nerve | 0 / 15768 | 0 | |
| ovary | 0 / 102051 | 0 | |
| pancreas | 0 / 214812 | 0 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 0 / 41328 | 0 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 0 / 280825 | 0 | |
| prostate | 0 / 189345 | 0 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 0 / 210574 | 0 | |
| spleen | 0 / 53952 | 0 | |
| stomach | 0 / 96619 | 0 | |
| testis | 0 / 330442 | 0 | |
| thymus | 0 / 81131 | 0 | |
| thyroid | 0 / 47473 | 0 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 0 / 52413 | 0 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 0 / 232878 | 0 | |
| vascular | 0 / 51780 | 0 |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 208729_x_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 7740.75 | |
| Adipocyte | 388.65 | |
| AdrenalCortex | 553.75 | |
| Adrenalgland | 1063.85 | |
| Amygdala | 343.2 | |
| Appendix | 1460 | |
| AtrioventricularNode | 130.3 | |
| BDCA4+_DentriticCells | 12085.65 | |
| Bonemarrow | 3622.25 | |
| BronchialEpithelialCells | 342.8 | |
| CD105+_Endothelial | 1609.4 | |
| CD14+_Monocytes | 13726.5 | |
| CD19+_BCells(neg._sel.) | 7109.7 | |
| CD33+_Myeloid | 16771.3 | |
| CD34+ | 4383.3 | |
| CD4+_Tcells | 11054.5 | |
| CD56+_NKCells | 19003.05 | |
| CD71+_EarlyErythroid | 770.2 | |
| CD8+_Tcells | 12143.35 | |
| CardiacMyocytes | 558.75 | |
| Caudatenucleus | 233.95 | |
| Cerebellum | 224.05 | |
| CerebellumPeduncles | 360.05 | |
| CiliaryGanglion | 252.75 | |
| CingulateCortex | 109.4 | |
| Colorectaladenocarcinoma | 1091.65 | |
| DorsalRootGanglion | 518.25 | |
| FetalThyroid | 932.5 | |
| Fetalbrain | 79.85 | |
| Fetalliver | 128.45 | |
| Fetallung | 1852.05 | |
| GlobusPallidus | 67.7 | |
| Heart | 4075.85 | |
| Hypothalamus | 522.6 | |
| Kidney | 638.8 | |
| Leukemia_chronicMyelogenousK-562 | 26.15 | |
| Leukemia_promyelocytic-HL-60 | 1603.1 | |
| Leukemialymphoblastic(MOLT-4) | 326.8 | |
| Liver | 1387.5 | |
| Lung | 10695.2 | |
| Lymphnode | 4311.4 | |
| Lymphoma_burkitts(Daudi) | 3258.35 | |
| Lymphoma_burkitts(Raji) | 6347.6 | |
| MedullaOblongata | 121.65 | |
| OccipitalLobe | 333.2 | |
| OlfactoryBulb | 844.55 | |
| Ovary | 676.5 | |
| Pancreas | 955 | |
| PancreaticIslet | 3086.55 | |
| ParietalLobe | 145.05 | |
| Pituitary | 943.1 | |
| Placenta | 1638.75 | |
| Pons | 180.4 | |
| PrefrontalCortex | 479.8 | |
| Prostate | 4237.65 | |
| Salivarygland | 1638.45 | |
| SkeletalMuscle | 188.2 | |
| Skin | 812.9 | |
| SmoothMuscle | 1055 | |
| Spinalcord | 742.15 | |
| SubthalamicNucleus | 83.05 | |
| SuperiorCervicalGanglion | 179.05 | |
| TemporalLobe | 175.05 | |
| Testis | 233 | |
| TestisGermCell | 569.3 | |
| TestisIntersitial | 200.25 | |
| TestisLeydigCell | 432.75 | |
| TestisSeminiferousTubule | 366.25 | |
| Thalamus | 335.8 | |
| Thymus | 2750 | |
| Thyroid | 3705.6 | |
| Tongue | 526.75 | |
| Tonsil | 4337.25 | |
| Trachea | 1867.7 | |
| TrigeminalGanglion | 364.25 | |
| Uterus | 1849.75 | |
| UterusCorpus | 768.05 | |
| WholeBlood | 15860.7 | |
| Wholebrain | 459.9 | |
| colon | 4961.7 | |
| pineal_day | 1860.02 | |
| pineal_night | 3431.9 | |
| retina | 2736.05 | |
| small_intestine | 2697.3 | |
- Probe name: A_23_P125107
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 7.13 ± 0.37 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 7.68 ± 0.17 | |
| Basal Part of Pons | 7.8 ± 0.42 | |
| Cerebellar Cortex | 7.48 ± 0.45 | |
| Cerebellar Nuclei | 8.05 ± 0.29 | |
| Claustrum | 6.94 ± 0.58 | |
| Epithalamus | 8.2 ± 0.5 | |
| Frontal Lobe | 7.7 ± 0.55 | |
| Globus Pallidus | 8.49 ± 0.31 | |
| Hypothalamus | 7.75 ± 0.74 | |
| Insula | 7.85 ± 0.3 | |
| Limbic Lobe | 7.46 ± 0.67 | |
| Mesencephalon | 7.74 ± 0.5 | |
| Myelencephalon | 7.82 ± 0.5 | |
| Occipital Lobe | 7.66 ± 0.58 | |
| Parietal Lobe | 7.37 ± 0.57 | |
| Pontine Tegmentum | 7.66 ± 0.61 | |
| Striatum | 8.16 ± 0.41 | |
| Subthalamus | 8 ± 0.41 | |
| Temporal Lobe | 7.65 ± 0.49 | |
| Thalamus | 7.92 ± 0.52 | |
| White Matter | 7.91 ± 1.03 | |
Mouse Brain ISH 
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| 1B07_HUMAN_0 | 0 | 0 | 0 | DGEDQTQDTELVETRPAGDR | PRIDE |
| PAp00000643 | 14 | 73 | 86 | APWIEQEGPEYWDR | Peptide Atlas |