AutismKB 2.0

Annotation Detail for HLA-DMA


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Basic Information Top
Gene Symbol:HLA-DMA ( D6S222E,DMA,HLADM,RING6 )
Gene Full Name: major histocompatibility complex, class II, DM alpha
Band: 6p21.32
Quick LinksEntrez ID:3108; OMIM: 142855; Uniprot ID:Q31604_HUMAN; ENSEMBL ID: ENSG00000204257; HGNC ID: 4934
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 217478_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts519.35
Adipocyte56.5
AdrenalCortex3.85
Adrenalgland68.45
Amygdala4.7
Appendix14.35
AtrioventricularNode3.3
BDCA4+_DentriticCells2163.95
Bonemarrow107
BronchialEpithelialCells3.4
CD105+_Endothelial95.55
CD14+_Monocytes1373.95
CD19+_BCells(neg._sel.)2302.85
CD33+_Myeloid1053
CD34+670.85
CD4+_Tcells28.9
CD56+_NKCells188.3
CD71+_EarlyErythroid4.8
CD8+_Tcells36.7
CardiacMyocytes4.4
Caudatenucleus3.65
Cerebellum3.45
CerebellumPeduncles3.75
CiliaryGanglion6.85
CingulateCortex4.35
Colorectaladenocarcinoma4.5
DorsalRootGanglion8.5
FetalThyroid4.2
Fetalbrain3.25
Fetalliver3.6
Fetallung21
GlobusPallidus2.4
Heart287.5
Hypothalamus5.75
Kidney14.9
Leukemia_chronicMyelogenousK-5622.95
Leukemia_promyelocytic-HL-60356.8
Leukemialymphoblastic(MOLT-4)2.65
Liver6.4
Lung689.15
Lymphnode397.15
Lymphoma_burkitts(Daudi)293.7
Lymphoma_burkitts(Raji)854.25
MedullaOblongata3.9
OccipitalLobe3.05
OlfactoryBulb26.05
Ovary3.75
Pancreas5.95
PancreaticIslet87.95
ParietalLobe3.65
Pituitary5.8
Placenta13.6
Pons3.4
PrefrontalCortex5.15
Prostate6.5
Salivarygland241.5
SkeletalMuscle5.05
Skin3.35
SmoothMuscle3.8
Spinalcord26.85
SubthalamicNucleus3.25
SuperiorCervicalGanglion5.45
TemporalLobe4.35
Testis3.6
TestisGermCell5.8
TestisIntersitial4.15
TestisLeydigCell4.15
TestisSeminiferousTubule3.85
Thalamus4.35
Thymus158.9
Thyroid21.6
Tongue4.35
Tonsil641.55
Trachea143.75
TrigeminalGanglion4.8
Uterus13.3
UterusCorpus3.95
WholeBlood271.15
Wholebrain3.65
colon24.55
pineal_day7.6
pineal_night8.36
retina53.2
small_intestine258.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P50245
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.47 ± 0.65
Basal Forebrain3.34 ± 0.52
Basal Part of Pons4.03 ± 0.58
Cerebellar Cortex3.44 ± 0.53
Cerebellar Nuclei4.71 ± 0.39
Claustrum2.96 ± 0.52
Epithalamus4.71 ± 0.57
Frontal Lobe3.55 ± 0.7
Globus Pallidus5.27 ± 0.43
Hypothalamus4.02 ± 1.03
Insula3.71 ± 0.57
Limbic Lobe3.36 ± 0.66
Mesencephalon3.68 ± 0.68
Myelencephalon3.59 ± 0.76
Occipital Lobe3.24 ± 0.74
Parietal Lobe3.39 ± 0.73
Pontine Tegmentum3.37 ± 0.64
Striatum4.05 ± 0.67
Subthalamus4.1 ± 0.67
Temporal Lobe3.5 ± 0.72
Thalamus3.66 ± 0.59
White Matter4.57 ± 0.46
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
H2-DMaCBCerebellum0
0
H2-DMaCTXCerebral cortex0
0
H2-DMaHIPHippocampal region0
0
H2-DMaHPFHippocampal formation0
0
H2-DMaHYHypothalamus0
0
H2-DMaLSXLateral septal complex0
0
H2-DMaMBMidbrain0
0
H2-DMaMYMedulla0
0
H2-DMaOLFOlfactory bulb0
0
H2-DMaPPons0
0
H2-DMaPALPallidum0
0
H2-DMaRHPRetrohippocampal region0
0
H2-DMasAMYStriatum-like amygdalar nuclei0
0
H2-DMaSTRStriatum0
0
H2-DMaSTRdStriatum dorsal region0
0
H2-DMaSTRvStriatum ventral region0
0
H2-DMaTHThalamus0
0
Peptide Top

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018