AutismKB 2.0

Annotation Detail for HLA-DPB1


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Basic Information Top
Gene Symbol:HLA-DPB1 ( DPB1,HLA-DP1B )
Gene Full Name: major histocompatibility complex, class II, DP beta 1
Band: 6p21.32
Quick LinksEntrez ID:3115; OMIM: 142858; Uniprot ID:DPB1_HUMAN; ENSEMBL ID: ENSG00000223865; HGNC ID: 4940
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus29 / 56401251
neonate1 / 3109732
infant0 / 236200 
juvenile2 / 5555635
adult285 / 1939121146
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor3 / 12794234
bladder carcinoma0 / 174750 
breast (mammary gland) tumor4 / 9417842
cervical tumor0 / 343660 
chondrosarcoma10 / 82823120
colorectal tumor4 / 11424635
esophageal tumor1 / 1729057
gastrointestinal tumor6 / 11936950
germ cell tumor10 / 26384537
glioma5 / 10688346
head and neck tumor7 / 13630251
kidney tumor5 / 6895972
leukemia4 / 9584241
liver tumor2 / 9635920
lung tumor19 / 103127184
lymphoma77 / 717551073
non-neoplasia20 / 97250205
normal351 / 3360307104
ovarian tumor17 / 76682221
pancreatic tumor14 / 104616133
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer7 / 10268068
retinoblastoma0 / 463560 
skin tumor4 / 12494932
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor35 / 90257387
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue4 / 13106305
adrenal gland8 / 33197240
ascites0 / 400150 
bladder1 / 2975733
blood13 / 123478105
bone8 / 71655111
bone marrow2 / 4880140
brain36 / 110098932
cervix0 / 481710 
connective tissue20 / 149255133
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus1 / 2020949
eye18 / 21105485
heart11 / 89626122
intestine15 / 23447263
kidney10 / 21177747
larynx0 / 241450 
liver5 / 20774324
lung73 / 336974216
lymph35 / 44270790
lymph node61 / 91610665
mammary gland8 / 15327152
mouth3 / 6705244
muscle9 / 10771583
nerve1 / 1576863
ovary18 / 102051176
pancreas30 / 214812139
parathyroid0 / 205390 
pharynx10 / 41328241
pituitary gland1 / 1658560
placenta9 / 28082532
prostate27 / 189345142
salivary gland2 / 2015599
skin5 / 21057423
spleen23 / 53952426
stomach25 / 96619258
testis8 / 33044224
thymus16 / 81131197
thyroid3 / 4747363
tonsil40 / 169992353
trachea0 / 524130 
umbilical cord0 / 136800 
uterus55 / 232878236
vascular7 / 51780135
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201137_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts1668.45
Adipocyte38.9
AdrenalCortex193.8
Adrenalgland376.45
Amygdala85.35
Appendix215.55
AtrioventricularNode79.75
BDCA4+_DentriticCells7741.7
Bonemarrow496.55
BronchialEpithelialCells9.2
CD105+_Endothelial623.8
CD14+_Monocytes2277.8
CD19+_BCells(neg._sel.)7212.05
CD33+_Myeloid3851.3
CD34+2786.5
CD4+_Tcells903.65
CD56+_NKCells3531.85
CD71+_EarlyErythroid155.85
CD8+_Tcells977.75
CardiacMyocytes27.2
Caudatenucleus116.35
Cerebellum173.95
CerebellumPeduncles276.35
CiliaryGanglion146.5
CingulateCortex17.25
Colorectaladenocarcinoma8.85
DorsalRootGanglion405.5
FetalThyroid18.75
Fetalbrain11.75
Fetalliver138.55
Fetallung273.6
GlobusPallidus30.25
Heart1138.2
Hypothalamus298
Kidney151.9
Leukemia_chronicMyelogenousK-5628.25
Leukemia_promyelocytic-HL-602484.45
Leukemialymphoblastic(MOLT-4)19.1
Liver888.75
Lung3864.25
Lymphnode2796.2
Lymphoma_burkitts(Daudi)509.85
Lymphoma_burkitts(Raji)8891.2
MedullaOblongata15.75
OccipitalLobe46.9
OlfactoryBulb794.35
Ovary205.2
Pancreas129.9
PancreaticIslet396.9
ParietalLobe64.65
Pituitary250
Placenta195.95
Pons74.2
PrefrontalCortex112.8
Prostate615.25
Salivarygland1193.7
SkeletalMuscle90
Skin209.8
SmoothMuscle51.6
Spinalcord741.75
SubthalamicNucleus16.95
SuperiorCervicalGanglion70.7
TemporalLobe51.4
Testis90.15
TestisGermCell85.25
TestisIntersitial55.5
TestisLeydigCell43.4
TestisSeminiferousTubule75.65
Thalamus139.3
Thymus1418.3
Thyroid588.45
Tongue73.5
Tonsil3191.25
Trachea655.05
TrigeminalGanglion251.6
Uterus511.05
UterusCorpus177.7
WholeBlood2652.95
Wholebrain98.6
colon290.9
pineal_day194.42
pineal_night373.9
retina916.325
small_intestine1396.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P166443
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.52 ± 0.37
Basal Forebrain7.08 ± 0.39
Basal Part of Pons6.92 ± 0.58
Cerebellar Cortex7.37 ± 0.26
Cerebellar Nuclei8.14 ± 0.39
Claustrum5.76 ± 0.57
Epithalamus8.18 ± 0.4
Frontal Lobe6.55 ± 0.56
Globus Pallidus7.85 ± 0.73
Hypothalamus7.55 ± 0.97
Insula6.75 ± 0.54
Limbic Lobe6.53 ± 0.43
Mesencephalon6.93 ± 0.5
Myelencephalon6.87 ± 0.66
Occipital Lobe7.19 ± 0.49
Parietal Lobe6.81 ± 0.51
Pontine Tegmentum6.76 ± 0.4
Striatum6.92 ± 0.71
Subthalamus7.2 ± 0.34
Temporal Lobe6.77 ± 0.55
Thalamus6.72 ± 0.42
White Matter7.5 ± 0.81
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00003044 24 134 157 GPLQHHNLLVCHVTDFYPGSIQVR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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