AutismKB 2.0

Annotation Detail for HLA-DQB1


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Basic Information Top
Gene Symbol:HLA-DQB1 ( CELIAC1,HLA-DQB,IDDM1 )
Gene Full Name: major histocompatibility complex, class II, DQ beta 1
Band: 6p21.32
Quick LinksEntrez ID:3119; OMIM: 604305; Uniprot ID:DQB1_HUMAN; ENSEMBL ID: ENSG00000179344; HGNC ID: 4944
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst1 / 6231916
fetus11 / 56401219
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult181 / 193912193
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma14 / 17475801
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma8 / 8282396
colorectal tumor6 / 11424652
esophageal tumor1 / 1729057
gastrointestinal tumor4 / 11936933
germ cell tumor6 / 26384522
glioma0 / 1068830 
head and neck tumor12 / 13630288
kidney tumor2 / 6895929
leukemia8 / 9584283
liver tumor2 / 9635920
lung tumor12 / 103127116
lymphoma28 / 71755390
non-neoplasia18 / 97250185
normal233 / 336030769
ovarian tumor13 / 76682169
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer6 / 10268058
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor17 / 90257188
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland1 / 3319730
ascites0 / 400150 
bladder13 / 29757436
blood27 / 123478218
bone2 / 7165527
bone marrow1 / 4880120
brain27 / 110098924
cervix1 / 4817120
connective tissue16 / 149255107
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus1 / 2020949
eye6 / 21105428
heart0 / 896260 
intestine19 / 23447281
kidney11 / 21177751
larynx0 / 241450 
liver2 / 2077439
lung64 / 336974189
lymph15 / 44270338
lymph node34 / 91610371
mammary gland11 / 15327171
mouth4 / 6705259
muscle2 / 10771518
nerve1 / 1576863
ovary15 / 102051146
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx10 / 41328241
pituitary gland2 / 16585120
placenta9 / 28082532
prostate13 / 18934568
salivary gland0 / 201550 
skin2 / 2105749
spleen25 / 53952463
stomach7 / 9661972
testis2 / 3304426
thymus5 / 8113161
thyroid10 / 47473210
tonsil26 / 169991529
trachea1 / 5241319
umbilical cord0 / 136800 
uterus23 / 23287898
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212999_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts407.65
Adipocyte7.65
AdrenalCortex12.8
Adrenalgland8.25
Amygdala7.8
Appendix12.85
AtrioventricularNode7.1
BDCA4+_DentriticCells150.95
Bonemarrow12.1
BronchialEpithelialCells7.25
CD105+_Endothelial9.55
CD14+_Monocytes29.95
CD19+_BCells(neg._sel.)910.3
CD33+_Myeloid87.15
CD34+17.8
CD4+_Tcells12.75
CD56+_NKCells10.05
CD71+_EarlyErythroid8.85
CD8+_Tcells8.6
CardiacMyocytes21.1
Caudatenucleus7.25
Cerebellum6.35
CerebellumPeduncles10.15
CiliaryGanglion9.55
CingulateCortex8.75
Colorectaladenocarcinoma8.4
DorsalRootGanglion6.95
FetalThyroid10.55
Fetalbrain7.4
Fetalliver7.25
Fetallung7.05
GlobusPallidus6.55
Heart19.85
Hypothalamus9.7
Kidney7.15
Leukemia_chronicMyelogenousK-5626.7
Leukemia_promyelocytic-HL-6040.85
Leukemialymphoblastic(MOLT-4)5.05
Liver19.4
Lung9.7
Lymphnode42.2
Lymphoma_burkitts(Daudi)12.6
Lymphoma_burkitts(Raji)137.75
MedullaOblongata7.25
OccipitalLobe7.5
OlfactoryBulb6.1
Ovary5.9
Pancreas9.3
PancreaticIslet16.5
ParietalLobe9.35
Pituitary10.45
Placenta7.95
Pons8.85
PrefrontalCortex9.5
Prostate10.2
Salivarygland8.75
SkeletalMuscle13.65
Skin10.75
SmoothMuscle10.15
Spinalcord9.55
SubthalamicNucleus9.45
SuperiorCervicalGanglion10.6
TemporalLobe8.15
Testis7.2
TestisGermCell6.6
TestisIntersitial8.5
TestisLeydigCell9.65
TestisSeminiferousTubule7.2
Thalamus9.05
Thymus10.85
Thyroid11.5
Tongue10.4
Tonsil57.4
Trachea7.35
TrigeminalGanglion13.95
Uterus6.45
UterusCorpus7.95
WholeBlood9.25
Wholebrain5.55
colon14.35
pineal_day10.68
pineal_night12.22
retina12.5
small_intestine24.55
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P239676
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala1.97 ± 1.03
Basal Forebrain1.49 ± 0.18
Basal Part of Pons1.23 ± 0.29
Cerebellar Cortex1.48 ± 0.69
Cerebellar Nuclei1.89 ± 0.68
Claustrum2.42 ± 0.85
Epithalamus1.26 ± 0.78
Frontal Lobe1.44 ± 0.71
Globus Pallidus2.04 ± 0.55
Hypothalamus1.58 ± 0.71
Insula1.44 ± 0.49
Limbic Lobe1.55 ± 0.65
Mesencephalon1.69 ± 0.68
Myelencephalon1.59 ± 0.67
Occipital Lobe1.67 ± 0.76
Parietal Lobe1.63 ± 0.62
Pontine Tegmentum1.61 ± 0.65
Striatum1.67 ± 0.55
Subthalamus1.72 ± 0.63
Temporal Lobe1.46 ± 0.57
Thalamus1.53 ± 0.58
White Matter1.94 ± 0.19
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
H2-Ab1CBCerebellum2.93
4.88
H2-Ab1CTXCerebral cortex3.65
3.72
H2-Ab1HIPHippocampal region1.15
1.23
H2-Ab1HPFHippocampal formation1.23
1.3
H2-Ab1HYHypothalamus1.43
1.33
H2-Ab1LSXLateral septal complex0.25
0.3
H2-Ab1MBMidbrain2.17
3.98
H2-Ab1MYMedulla3.98
4.57
H2-Ab1OLFOlfactory bulb9.42
7.66
H2-Ab1PPons3.03
3.4
H2-Ab1PALPallidum0.84
0.83
H2-Ab1RHPRetrohippocampal region1.32
1.35
H2-Ab1sAMYStriatum-like amygdalar nuclei0.71
0.92
H2-Ab1STRStriatum1.2
1.5
H2-Ab1STRdStriatum dorsal region0.56
0.67
H2-Ab1STRvStriatum ventral region3.98
4.47
H2-Ab1THThalamus0.7
0.83
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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