AutismKB 2.0

Annotation Detail for HLA-DRB5


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Basic Information Top
Gene Symbol:HLA-DRB5 ( FLJ76359,HLA-DRB )
Gene Full Name: major histocompatibility complex, class II, DR beta 5
Band: 6p21.32
Quick LinksEntrez ID:3127; OMIM: 604776; Uniprot ID:DRB5_HUMAN; ENSEMBL ID: ENSG00000198502; HGNC ID: 4953
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 215193_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts4931.25
Adipocyte42
AdrenalCortex249.7
Adrenalgland666.95
Amygdala121.9
Appendix417.3
AtrioventricularNode154.85
BDCA4+_DentriticCells7491
Bonemarrow579.65
BronchialEpithelialCells25.85
CD105+_Endothelial368.5
CD14+_Monocytes6158.3
CD19+_BCells(neg._sel.)5827.45
CD33+_Myeloid3392.15
CD34+1807.15
CD4+_Tcells461.1
CD56+_NKCells1279
CD71+_EarlyErythroid50.65
CD8+_Tcells477.75
CardiacMyocytes69.3
Caudatenucleus104.7
Cerebellum62.5
CerebellumPeduncles98.35
CiliaryGanglion260.1
CingulateCortex40.35
Colorectaladenocarcinoma46.75
DorsalRootGanglion378.45
FetalThyroid35.25
Fetalbrain15.95
Fetalliver102.8
Fetallung447.35
GlobusPallidus43.8
Heart3032.75
Hypothalamus414.7
Kidney395.85
Leukemia_chronicMyelogenousK-56225.1
Leukemia_promyelocytic-HL-603663.9
Leukemialymphoblastic(MOLT-4)25.1
Liver1112.1
Lung7930.1
Lymphnode2758.8
Lymphoma_burkitts(Daudi)2018
Lymphoma_burkitts(Raji)7979.25
MedullaOblongata47.45
OccipitalLobe58.3
OlfactoryBulb429.15
Ovary262.6
Pancreas377.35
PancreaticIslet657
ParietalLobe71.3
Pituitary439.9
Placenta396.05
Pons103.8
PrefrontalCortex170.85
Prostate561.6
Salivarygland1161.2
SkeletalMuscle109.1
Skin239.7
SmoothMuscle43.25
Spinalcord636.55
SubthalamicNucleus29.65
SuperiorCervicalGanglion116.2
TemporalLobe83.35
Testis149.3
TestisGermCell138.8
TestisIntersitial84.85
TestisLeydigCell94.45
TestisSeminiferousTubule81.55
Thalamus138.75
Thymus1895
Thyroid804.65
Tongue173.4
Tonsil3236.25
Trachea1118.35
TrigeminalGanglion236.65
Uterus740.1
UterusCorpus289.25
WholeBlood2821.7
Wholebrain128.15
colon989.45
pineal_day247.1
pineal_night268.32
retina1061.625
small_intestine3327.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P45099
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.36 ± 0.83
Basal Forebrain3.43 ± 0.58
Basal Part of Pons4.41 ± 0.79
Cerebellar Cortex3.23 ± 0.46
Cerebellar Nuclei5.66 ± 0.29
Claustrum3.06 ± 0.74
Epithalamus5.64 ± 0.56
Frontal Lobe3.65 ± 0.98
Globus Pallidus5.76 ± 0.51
Hypothalamus3.92 ± 1.58
Insula4.18 ± 0.76
Limbic Lobe3.37 ± 0.8
Mesencephalon3.86 ± 0.79
Myelencephalon3.77 ± 0.91
Occipital Lobe3.39 ± 0.71
Parietal Lobe3.47 ± 0.74
Pontine Tegmentum3.54 ± 0.84
Striatum4.74 ± 0.72
Subthalamus4.27 ± 0.78
Temporal Lobe3.66 ± 0.65
Thalamus3.6 ± 0.64
White Matter5.24 ± 0.85
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00003474 13 110 122 HNYGVGESFTVQR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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