AutismKB 2.0

Annotation Detail for HLA-E


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Basic Information Top
Gene Symbol:HLA-E ( DKFZp686P19218,EA1.2,EA2.1,HLA-6.2,MHC,QA1 )
Gene Full Name: major histocompatibility complex, class I, E
Band: 6p22.1
Quick LinksEntrez ID:3133; OMIM: 143010; Uniprot ID:HLAE_HUMAN; ENSEMBL ID: ENSG00000204592; HGNC ID: 4962
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst3 / 6231948
fetus88 / 564012156
neonate6 / 31097192
infant2 / 2362084
juvenile13 / 55556233
adult825 / 1939121425
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma5 / 17475286
breast (mammary gland) tumor42 / 94178445
cervical tumor12 / 34366349
chondrosarcoma33 / 82823398
colorectal tumor38 / 114246332
esophageal tumor9 / 17290520
gastrointestinal tumor53 / 119369444
germ cell tumor19 / 26384572
glioma35 / 106883327
head and neck tumor43 / 136302315
kidney tumor15 / 68959217
leukemia47 / 95842490
liver tumor16 / 96359166
lung tumor31 / 103127300
lymphoma44 / 71755613
non-neoplasia51 / 97250524
normal1202 / 3360307357
ovarian tumor35 / 76682456
pancreatic tumor83 / 104616793
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer12 / 102680116
retinoblastoma0 / 463560 
skin tumor44 / 124949352
soft tissue/muscle tissue tumor12 / 12519195
uterine tumor32 / 90257354
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue30 / 131062289
adrenal gland15 / 33197451
ascites7 / 40015174
bladder8 / 29757268
blood93 / 123478753
bone33 / 71655460
bone marrow11 / 48801225
brain214 / 1100989194
cervix14 / 48171290
connective tissue46 / 149255308
ear0 / 162120 
embryonic tissue11 / 21572250
esophagus10 / 20209494
eye42 / 211054199
heart34 / 89626379
intestine119 / 234472507
kidney65 / 211777306
larynx7 / 24145289
liver30 / 207743144
lung275 / 336974816
lymph26 / 44270587
lymph node35 / 91610382
mammary gland88 / 153271574
mouth13 / 67052193
muscle34 / 107715315
nerve8 / 15768507
ovary45 / 102051440
pancreas109 / 214812507
parathyroid28 / 205391363
pharynx15 / 41328362
pituitary gland3 / 16585180
placenta91 / 280825324
prostate37 / 189345195
salivary gland6 / 20155297
skin113 / 210574536
spleen78 / 539521445
stomach58 / 96619600
testis24 / 33044272
thymus29 / 81131357
thyroid22 / 47473463
tonsil33 / 169991941
trachea4 / 5241376
umbilical cord3 / 13680219
uterus74 / 232878317
vascular12 / 51780231
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 200904_at
Cell line Expression level Expression bar
721_B_lymphoblasts329.95
Adipocyte207.15
AdrenalCortex101.55
Adrenalgland132.35
Amygdala69.45
Appendix332.15
AtrioventricularNode97.95
BDCA4+_DentriticCells1057.2
Bonemarrow294.45
BronchialEpithelialCells134.25
CD105+_Endothelial103.55
CD14+_Monocytes1912.95
CD19+_BCells(neg._sel.)2626.95
CD33+_Myeloid1072.8
CD34+303.9
CD4+_Tcells2047.95
CD56+_NKCells2594.25
CD71+_EarlyErythroid13.75
CD8+_Tcells1849.7
CardiacMyocytes73.6
Caudatenucleus33.05
Cerebellum59.2
CerebellumPeduncles73.85
CiliaryGanglion106
CingulateCortex41.5
Colorectaladenocarcinoma53.45
DorsalRootGanglion183.35
FetalThyroid328.75
Fetalbrain17.7
Fetalliver25.7
Fetallung359.3
GlobusPallidus21.5
Heart481.1
Hypothalamus243.3
Kidney132.6
Leukemia_chronicMyelogenousK-56213.8
Leukemia_promyelocytic-HL-6049.85
Leukemialymphoblastic(MOLT-4)87.95
Liver308.25
Lung2449.25
Lymphnode1119.3
Lymphoma_burkitts(Daudi)59.35
Lymphoma_burkitts(Raji)371.55
MedullaOblongata49.4
OccipitalLobe79.45
OlfactoryBulb435.8
Ovary236.2
Pancreas132.75
PancreaticIslet1241.35
ParietalLobe45.45
Pituitary80
Placenta497.9
Pons40.95
PrefrontalCortex183.5
Prostate453.15
Salivarygland378.25
SkeletalMuscle66.65
Skin240.15
SmoothMuscle149.35
Spinalcord333.7
SubthalamicNucleus53.95
SuperiorCervicalGanglion45.15
TemporalLobe50.55
Testis31.5
TestisGermCell94.65
TestisIntersitial63.7
TestisLeydigCell79.85
TestisSeminiferousTubule58.55
Thalamus108.05
Thymus436.15
Thyroid642.1
Tongue206.3
Tonsil659.35
Trachea318.55
TrigeminalGanglion186.6
Uterus388.85
UterusCorpus114.6
WholeBlood4683.5
Wholebrain135.6
colon478
pineal_day65.5
pineal_night52.48
retina700.075
small_intestine464.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P30848
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.53 ± 0.39
Basal Forebrain7.82 ± 0.23
Basal Part of Pons7.69 ± 0.34
Cerebellar Cortex7.37 ± 0.23
Cerebellar Nuclei8.33 ± 0.3
Claustrum7.85 ± 0.35
Epithalamus8.61 ± 0.35
Frontal Lobe7.7 ± 0.43
Globus Pallidus9.13 ± 0.37
Hypothalamus7.76 ± 0.77
Insula7.53 ± 0.37
Limbic Lobe7.57 ± 0.56
Mesencephalon7.91 ± 0.37
Myelencephalon7.93 ± 0.38
Occipital Lobe7.71 ± 0.49
Parietal Lobe7.62 ± 0.45
Pontine Tegmentum7.75 ± 0.48
Striatum8.39 ± 0.53
Subthalamus7.9 ± 0.36
Temporal Lobe7.66 ± 0.37
Thalamus7.94 ± 0.35
White Matter8.97 ± 0.41
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
HLAE_HUMAN_265 13 265 277 WAAVVVPSGEEQR PRIDE
HLAE_HUMAN_43 14 43 56 FISVGYVDDTQFVR PRIDE
PAp00033875 14 43 56 FISVGYVDDTQFVR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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