AutismKB 2.0

Annotation Detail for HLX


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Basic Information Top
Gene Symbol:HLX ( HB24,HLX1 )
Gene Full Name: H2.0-like homeobox
Band: 1q41
Quick LinksEntrez ID:3142; OMIM: 142995; Uniprot ID:HLX_HUMAN; ENSEMBL ID: ENSG00000136630; HGNC ID: 4978
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus5 / 5640128
neonate2 / 3109764
infant0 / 236200 
juvenile1 / 5555617
adult27 / 193912113
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma4 / 8282348
colorectal tumor0 / 1142460 
esophageal tumor1 / 1729057
gastrointestinal tumor1 / 1193698
germ cell tumor5 / 26384518
glioma1 / 1068839
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia4 / 9584241
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia4 / 9725041
normal38 / 336030711
ovarian tumor0 / 766820 
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma2 / 4635643
skin tumor6 / 12494948
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood4 / 12347832
bone1 / 7165513
bone marrow0 / 488010 
brain5 / 11009894
cervix3 / 4817162
connective tissue7 / 14925546
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus1 / 2020949
eye4 / 21105418
heart1 / 8962611
intestine6 / 23447225
kidney3 / 21177714
larynx0 / 241450 
liver1 / 2077434
lung5 / 33697414
lymph0 / 442700 
lymph node0 / 916100 
mammary gland2 / 15327113
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta7 / 28082524
prostate0 / 1893450 
salivary gland0 / 201550 
skin7 / 21057433
spleen2 / 5395237
stomach0 / 966190 
testis0 / 3304420 
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus4 / 23287817
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 214438_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.3
Adipocyte4.25
AdrenalCortex4.6
Adrenalgland3.6
Amygdala4.5
Appendix4.35
AtrioventricularNode3.35
BDCA4+_DentriticCells5
Bonemarrow9.4
BronchialEpithelialCells4.15
CD105+_Endothelial4.35
CD14+_Monocytes46.2
CD19+_BCells(neg._sel.)5.65
CD33+_Myeloid74.75
CD34+7.7
CD4+_Tcells4.7
CD56+_NKCells5.05
CD71+_EarlyErythroid4.05
CD8+_Tcells4.2
CardiacMyocytes5.55
Caudatenucleus3.85
Cerebellum3.45
CerebellumPeduncles4.9
CiliaryGanglion3.15
CingulateCortex4.35
Colorectaladenocarcinoma4.3
DorsalRootGanglion3.3
FetalThyroid4.2
Fetalbrain4.3
Fetalliver3.7
Fetallung5.95
GlobusPallidus3.15
Heart5.65
Hypothalamus4.7
Kidney3.5
Leukemia_chronicMyelogenousK-5623.9
Leukemia_promyelocytic-HL-603.8
Leukemialymphoblastic(MOLT-4)3.45
Liver6.1
Lung25.45
Lymphnode3.7
Lymphoma_burkitts(Daudi)5.45
Lymphoma_burkitts(Raji)6.05
MedullaOblongata3.9
OccipitalLobe3.9
OlfactoryBulb3.4
Ovary2.85
Pancreas3.45
PancreaticIslet4.6
ParietalLobe4.55
Pituitary4.95
Placenta4.55
Pons4.1
PrefrontalCortex5.25
Prostate5.05
Salivarygland3.45
SkeletalMuscle5.1
Skin3.35
SmoothMuscle4.9
Spinalcord4.6
SubthalamicNucleus3.95
SuperiorCervicalGanglion4.9
TemporalLobe3.95
Testis3.7
TestisGermCell3.6
TestisIntersitial3.6
TestisLeydigCell4.25
TestisSeminiferousTubule3.7
Thalamus4.35
Thymus3.4
Thyroid5.45
Tongue4.25
Tonsil4.2
Trachea3.6
TrigeminalGanglion4.35
Uterus3.55
UterusCorpus3.85
WholeBlood35.35
Wholebrain3.65
colon4.4
pineal_day5.3
pineal_night5.24
retina5.225
small_intestine4.2
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16706_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.52 ± 0.91
Basal Forebrain1.76 ± 0.23
Basal Part of Pons1.82 ± 0.66
Cerebellar Cortex1.85 ± 0.84
Cerebellar Nuclei2.26 ± 0.69
Claustrum2.72 ± 0.8
Epithalamus1.74 ± 0.67
Frontal Lobe1.89 ± 0.66
Globus Pallidus2.59 ± 0.53
Hypothalamus1.97 ± 0.62
Insula2.09 ± 1.02
Limbic Lobe2.08 ± 0.67
Mesencephalon2.17 ± 0.76
Myelencephalon2.12 ± 0.75
Occipital Lobe2.17 ± 0.79
Parietal Lobe1.94 ± 0.76
Pontine Tegmentum2.02 ± 0.64
Striatum2.15 ± 0.64
Subthalamus2.08 ± 0.63
Temporal Lobe1.95 ± 0.72
Thalamus2.03 ± 0.69
White Matter2.24 ± 0.12
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Hlx1CBCerebellum38.3
48.56
Hlx1CTXCerebral cortex67.81
55.96
Hlx1HIPHippocampal region22
21.16
Hlx1HPFHippocampal formation28.7
25.49
Hlx1HYHypothalamus36.35
27.52
Hlx1LSXLateral septal complex42.5
34.49
Hlx1MBMidbrain49.47
46.39
Hlx1MYMedulla65.45
72.31
Hlx1OLFOlfactory bulb58.75
49.96
Hlx1PPons52.15
55.54
Hlx1PALPallidum42.1
38.24
Hlx1RHPRetrohippocampal region43.57
34.56
Hlx1sAMYStriatum-like amygdalar nuclei31.52
21.82
Hlx1STRStriatum32.63
22.62
Hlx1STRdStriatum dorsal region30.23
20.71
Hlx1STRvStriatum ventral region41.21
26.68
Hlx1THThalamus49.78
42.34
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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