AutismKB 2.0

Annotation Detail for HMGN2


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Basic Information Top
Gene Symbol:HMGN2 ( HMG17,MGC5629,MGC88718 )
Gene Full Name: high-mobility group nucleosomal binding domain 2
Band: 1p36.11
Quick LinksEntrez ID:3151; OMIM: 163910; Uniprot ID:HMGN2_HUMAN; ENSEMBL ID: ENSG00000198830; HGNC ID: 4986
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body74 / 707611045
blastocyst58 / 62319930
fetus122 / 564012216
neonate0 / 310970 
infant4 / 23620169
juvenile19 / 55556341
adult531 / 1939121273
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor9 / 12794703
bladder carcinoma3 / 17475171
breast (mammary gland) tumor39 / 94178414
cervical tumor46 / 343661338
chondrosarcoma50 / 82823603
colorectal tumor58 / 114246507
esophageal tumor3 / 17290173
gastrointestinal tumor56 / 119369469
germ cell tumor131 / 263845496
glioma19 / 106883177
head and neck tumor18 / 136302132
kidney tumor40 / 68959580
leukemia37 / 95842386
liver tumor51 / 96359529
lung tumor129 / 1031271250
lymphoma80 / 717551114
non-neoplasia15 / 97250154
normal921 / 3360307274
ovarian tumor37 / 76682482
pancreatic tumor60 / 104616573
primitive neuroectodermal tumor of the CNS47 / 125680373
prostate cancer45 / 102680438
retinoblastoma76 / 463561639
skin tumor103 / 124949824
soft tissue/muscle tissue tumor126 / 1251911006
uterine tumor66 / 90257731
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue4 / 13106305
adrenal gland11 / 33197331
ascites17 / 40015424
bladder12 / 29757403
blood43 / 123478348
bone55 / 71655767
bone marrow13 / 48801266
brain207 / 1100989188
cervix47 / 48171975
connective tissue35 / 149255234
ear5 / 16212308
embryonic tissue219 / 2157221015
esophagus4 / 20209197
eye138 / 211054653
heart17 / 89626189
intestine98 / 234472417
kidney60 / 211777283
larynx1 / 2414541
liver96 / 207743462
lung207 / 336974614
lymph61 / 442701377
lymph node38 / 91610414
mammary gland46 / 153271300
mouth6 / 6705289
muscle70 / 107715649
nerve4 / 15768253
ovary48 / 102051470
pancreas80 / 214812372
parathyroid4 / 20539194
pharynx52 / 413281258
pituitary gland7 / 16585422
placenta84 / 280825299
prostate58 / 189345306
salivary gland13 / 20155645
skin121 / 210574574
spleen17 / 53952315
stomach34 / 96619351
testis44 / 330442133
thymus26 / 81131320
thyroid2 / 4747342
tonsil26 / 169991529
trachea0 / 524130 
umbilical cord0 / 136800 
uterus151 / 232878648
vascular8 / 51780154
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208668_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts5070.1
Adipocyte689
AdrenalCortex561.75
Adrenalgland1160.75
Amygdala787.35
Appendix722.25
AtrioventricularNode308.5
BDCA4+_DentriticCells3577.3
Bonemarrow4150.95
BronchialEpithelialCells1738.8
CD105+_Endothelial4962.6
CD14+_Monocytes2374.7
CD19+_BCells(neg._sel.)3328.7
CD33+_Myeloid4410.55
CD34+6325.05
CD4+_Tcells2489.8
CD56+_NKCells3252.1
CD71+_EarlyErythroid4544.15
CD8+_Tcells1779.4
CardiacMyocytes2351.3
Caudatenucleus445.15
Cerebellum811.5
CerebellumPeduncles732.45
CiliaryGanglion259.8
CingulateCortex544.8
Colorectaladenocarcinoma2208.65
DorsalRootGanglion436.5
FetalThyroid2874
Fetalbrain1114.05
Fetalliver1610.75
Fetallung1569.15
GlobusPallidus269.4
Heart1442.5
Hypothalamus1213.8
Kidney824.5
Leukemia_chronicMyelogenousK-5621629.45
Leukemia_promyelocytic-HL-604020.75
Leukemialymphoblastic(MOLT-4)3965.4
Liver987.1
Lung2392.1
Lymphnode1471.35
Lymphoma_burkitts(Daudi)5682.8
Lymphoma_burkitts(Raji)3365.9
MedullaOblongata545.15
OccipitalLobe640.6
OlfactoryBulb1174.2
Ovary1379.6
Pancreas796.2
PancreaticIslet1334.05
ParietalLobe490.8
Pituitary2984.7
Placenta1895.4
Pons435.05
PrefrontalCortex1202.8
Prostate3524
Salivarygland895.5
SkeletalMuscle244.55
Skin352.3
SmoothMuscle1576.25
Spinalcord1292.35
SubthalamicNucleus370.95
SuperiorCervicalGanglion238.2
TemporalLobe381.6
Testis1523.6
TestisGermCell1397.35
TestisIntersitial832.6
TestisLeydigCell925.75
TestisSeminiferousTubule886.95
Thalamus649.7
Thymus5012.3
Thyroid3732.9
Tongue801.75
Tonsil2622.05
Trachea983.25
TrigeminalGanglion337.75
Uterus1489.75
UterusCorpus417.6
WholeBlood2313.1
Wholebrain1057.65
colon2777.9
pineal_day2582.1
pineal_night2962.52
retina2634.525
small_intestine2833
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P711477
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.89 ± 0.24
Basal Forebrain8.18 ± 0.09
Basal Part of Pons7.89 ± 0.2
Cerebellar Cortex7.83 ± 0.14
Cerebellar Nuclei7.95 ± 0.29
Claustrum7.95 ± 0.24
Epithalamus7.98 ± 0.1
Frontal Lobe7.89 ± 0.24
Globus Pallidus8.37 ± 0.2
Hypothalamus7.97 ± 0.27
Insula7.93 ± 0.18
Limbic Lobe8.02 ± 0.35
Mesencephalon8.06 ± 0.32
Myelencephalon8.05 ± 0.3
Occipital Lobe8.31 ± 0.35
Parietal Lobe7.99 ± 0.24
Pontine Tegmentum7.98 ± 0.26
Striatum8.54 ± 0.22
Subthalamus8.19 ± 0.25
Temporal Lobe7.94 ± 0.21
Thalamus7.97 ± 0.22
White Matter8.89 ± 0.09
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Hmgn2CBCerebellum24.15
31.56
Hmgn2CTXCerebral cortex73.79
58.43
Hmgn2HIPHippocampal region80.98
100
Hmgn2HPFHippocampal formation82.94
100
Hmgn2HYHypothalamus40.15
33.48
Hmgn2LSXLateral septal complex9.69
8.89
Hmgn2MBMidbrain52.67
46.17
Hmgn2MYMedulla51.97
48.38
Hmgn2OLFOlfactory bulb58.74
49.15
Hmgn2PPons63.04
54.29
Hmgn2PALPallidum49.98
44.52
Hmgn2RHPRetrohippocampal region86.62
74.49
Hmgn2sAMYStriatum-like amygdalar nuclei100
81.16
Hmgn2STRStriatum96.42
80.89
Hmgn2STRdStriatum dorsal region100
86.16
Hmgn2STRvStriatum ventral region87.37
71.86
Hmgn2THThalamus45.06
36.47
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
HMGN2_HUMAN_27 15 27 41 LSAKPAPPKPEPKPK PRIDE
HMGN2_HUMAN_5 19 5 23 KAEGDAKGDKAKVKDEPQR PRIDE
HMGN2_HUMAN_64 26 64 89 EGNNPAENGDAKTDQAQKAEGAGDAK PRIDE
HMGN2_HUMAN_68 22 68 89 PAENGDAKTDQAQKAEGAGDAK PRIDE
HMGN2_HUMAN_77 13 77 89 DQAQKAEGAGDAK PRIDE
PAp00066100 12 65 76 EGNNPAENGDAK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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