Annotation Detail for APAF1
Basic Information Top
| Gene Symbol: | APAF1 ( APAF-1,CED4,DKFZp781B1145 ) |
|---|---|
| Gene Full Name: | apoptotic peptidase activating factor 1 |
| Band: | 12q23.1 |
| Quick Links | Entrez ID:317; OMIM: 602233; Uniprot ID:APAF_HUMAN; ENSEMBL ID: ENSG00000120868; HGNC ID: 576 |
| Relate to Another Database: | SFARIGene; denovo-db |
Unigene EST- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 204859_s_at
| Cell line | Expression level | Expression bar |
|---|---|---|
 | ||
| 721_B_lymphoblasts | 22.9 |  |
| Adipocyte | 13.95 | |
| AdrenalCortex | 24.35 | |
| Adrenalgland | 15.35 | |
| Amygdala | 14.2 | |
| Appendix | 24.95 | |
| AtrioventricularNode | 38.95 | |
| BDCA4+_DentriticCells | 75.5 |  |
| Bonemarrow | 21.55 | |
| BronchialEpithelialCells | 15.35 | |
| CD105+_Endothelial | 24.6 | |
| CD14+_Monocytes | 200.85 |  |
| CD19+_BCells(neg._sel.) | 30.6 | |
| CD33+_Myeloid | 194.9 | |
| CD34+ | 25.8 | |
| CD4+_Tcells | 16.05 | |
| CD56+_NKCells | 66.3 | |
| CD71+_EarlyErythroid | 15.5 | |
| CD8+_Tcells | 22.5 | |
| CardiacMyocytes | 39.7 | |
| Caudatenucleus | 12.95 | |
| Cerebellum | 10.35 | |
| CerebellumPeduncles | 21.55 | |
| CiliaryGanglion | 19.6 | |
| CingulateCortex | 15.95 | |
| Colorectaladenocarcinoma | 15.4 | |
| DorsalRootGanglion | 18.65 | |
| FetalThyroid | 17.45 | |
| Fetalbrain | 15.9 | |
| Fetalliver | 14.85 | |
| Fetallung | 12.95 | |
| GlobusPallidus | 13.95 | |
| Heart | 31.25 | |
| Hypothalamus | 14.15 | |
| Kidney | 14.9 | |
| Leukemia_chronicMyelogenousK-562 | 14.5 | |
| Leukemia_promyelocytic-HL-60 | 13.15 | |
| Leukemialymphoblastic(MOLT-4) | 15.6 | |
| Liver | 24.1 | |
| Lung | 15.2 | |
| Lymphnode | 13.35 | |
| Lymphoma_burkitts(Daudi) | 27.85 | |
| Lymphoma_burkitts(Raji) | 25.4 | |
| MedullaOblongata | 11.2 | |
| OccipitalLobe | 11 | |
| OlfactoryBulb | 12.5 | |
| Ovary | 14 | |
| Pancreas | 15 | |
| PancreaticIslet | 18.05 | |
| ParietalLobe | 16.5 | |
| Pituitary | 18.6 | |
| Placenta | 15 | |
| Pons | 14.75 | |
| PrefrontalCortex | 16.9 | |
| Prostate | 17.7 | |
| Salivarygland | 14.45 | |
| SkeletalMuscle | 32.7 | |
| Skin | 31.3 | |
| SmoothMuscle | 24 | |
| Spinalcord | 16 | |
| SubthalamicNucleus | 17.15 | |
| SuperiorCervicalGanglion | 32.45 | |
| TemporalLobe | 14.15 | |
| Testis | 11.9 | |
| TestisGermCell | 11.2 | |
| TestisIntersitial | 13.1 | |
| TestisLeydigCell | 18.05 | |
| TestisSeminiferousTubule | 12.5 | |
| Thalamus | 15.45 | |
| Thymus | 12.05 | |
| Thyroid | 17.85 | |
| Tongue | 21.65 | |
| Tonsil | 16.9 | |
| Trachea | 11.95 | |
| TrigeminalGanglion | 27.05 | |
| Uterus | 12.65 | |
| UterusCorpus | 19.9 | |
| WholeBlood | 155.45 | |
| Wholebrain | 9.7 |  |
| colon | 16.2 | |
| pineal_day | 25.22 | |
| pineal_night | 20.82 | |
| retina | 17.45 | |
| small_intestine | 15.15 | |
- Probe name: CUST_1241_PI416573500
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 6.89 ± 0.28 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 6.6 ± 0.17 | |
| Basal Part of Pons | 6.5 ± 0.25 | |
| Cerebellar Cortex | 6.8 ± 0.14 | |
| Cerebellar Nuclei | 6.65 ± 0.17 | |
| Claustrum | 6.67 ± 0.38 | |
| Epithalamus | 7.07 ± 0.23 | |
| Frontal Lobe | 6.45 ± 0.28 | |
| Globus Pallidus | 6.7 ± 0.08 | |
| Hypothalamus | 6.57 ± 0.32 | |
| Insula | 6.75 ± 0.24 | |
| Limbic Lobe | 6.62 ± 0.35 | |
| Mesencephalon | 6.53 ± 0.25 | |
| Myelencephalon | 6.54 ± 0.32 | |
| Occipital Lobe | 6.61 ± 0.2 | |
| Parietal Lobe | 6.55 ± 0.27 | |
| Pontine Tegmentum | 6.55 ± 0.3 | |
| Striatum | 6.21 ± 0.24 | |
| Subthalamus | 6.24 ± 0.22 | |
| Temporal Lobe | 6.67 ± 0.25 | |
| Thalamus | 6.49 ± 0.26 | |
| White Matter | 7.18 ± 0.34 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Apaf1 | CB | Cerebellum | 100 | |
| 100 | | |||
| Apaf1 | CTX | Cerebral cortex | 98.36 | |
| 94.42 | | |||
| Apaf1 | HIP | Hippocampal region | 45.3 | |
| 51.77 | | |||
| Apaf1 | HPF | Hippocampal formation | 63.01 | |
| 66.1 | | |||
| Apaf1 | HY | Hypothalamus | 26.14 | |
| 21.85 | | |||
| Apaf1 | LSX | Lateral septal complex | 13.34 | |
| 12.37 | | |||
| Apaf1 | MB | Midbrain | 48.89 | |
| 47.13 | | |||
| Apaf1 | MY | Medulla | 100 | |
| 100 | | |||
| Apaf1 | OLF | Olfactory bulb | 86.54 | |
| 92.28 | | |||
| Apaf1 | P | Pons | 70.41 | |
| 79.43 | | |||
| Apaf1 | PAL | Pallidum | 35.38 | |
| 32.68 | | |||
| Apaf1 | RHP | Retrohippocampal region | 100 | |
| 93.47 | | |||
| Apaf1 | sAMY | Striatum-like amygdalar nuclei | 52.28 | |
| 38.05 | | |||
| Apaf1 | STR | Striatum | 36.75 | |
| 26.77 | | |||
| Apaf1 | STRd | Striatum dorsal region | 35.91 | |
| 26.52 | | |||
| Apaf1 | STRv | Striatum ventral region | 37.98 | |
| 25.08 | | |||
| Apaf1 | TH | Thalamus | 38.79 | |
| 31.32 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| APAF_HUMAN_0 | 0 | 0 | 0 | GSPLVVSLIGALLR | PRIDE |
| APAF_HUMAN_1110 | 14 | 1110 | 1123 | IWSFDLLLPLHELR | PRIDE |
| APAF_HUMAN_318 | 14 | 318 | 331 | GSPLVVSLIGALLR | PRIDE |
| PAp00498033 | 19 | 82 | 100 | DLAALLHDGIPVVSSSSGK | Peptide Atlas |