AutismKB 2.0

Annotation Detail for HNMT


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:HNMT ( HMT,HNMT-S1,HNMT-S2 )
Gene Full Name: histamine N-methyltransferase
Band: 2q22.1
Quick LinksEntrez ID:3176; OMIM: 605238; Uniprot ID:HNMT_HUMAN; ENSEMBL ID: ENSG00000150540; HGNC ID: 5028
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus36 / 56401263
neonate1 / 3109732
infant0 / 236200 
juvenile2 / 5555635
adult76 / 193912139
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma5 / 17475286
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor2 / 2638457
glioma4 / 10688337
head and neck tumor0 / 1363020 
kidney tumor2 / 6895929
leukemia0 / 958420 
liver tumor4 / 9635941
lung tumor1 / 1031279
lymphoma1 / 7175513
non-neoplasia4 / 9725041
normal163 / 336030748
ovarian tumor1 / 7668213
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor3 / 12494924
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites0 / 400150 
bladder6 / 29757201
blood1 / 1234788
bone0 / 716550 
bone marrow1 / 4880120
brain19 / 110098917
cervix0 / 481710 
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus1 / 2020949
eye1 / 2110544
heart2 / 8962622
intestine10 / 23447242
kidney28 / 211777132
larynx0 / 241450 
liver25 / 207743120
lung8 / 33697423
lymph0 / 442700 
lymph node1 / 9161010
mammary gland5 / 15327132
mouth0 / 670520 
muscle2 / 10771518
nerve0 / 157680 
ovary2 / 10205119
pancreas5 / 21481223
parathyroid1 / 2053948
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta14 / 28082549
prostate3 / 18934515
salivary gland0 / 201550 
skin8 / 21057437
spleen0 / 539520 
stomach3 / 9661931
testis2 / 3304426
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord1 / 1368073
uterus9 / 23287838
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204112_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.35
Adipocyte167.7
AdrenalCortex8.95
Adrenalgland7
Amygdala15.1
Appendix11.35
AtrioventricularNode6.95
BDCA4+_DentriticCells8.6
Bonemarrow8.35
BronchialEpithelialCells6.8
CD105+_Endothelial16.9
CD14+_Monocytes289.95
CD19+_BCells(neg._sel.)7.65
CD33+_Myeloid353.7
CD34+9.3
CD4+_Tcells7.45
CD56+_NKCells8.35
CD71+_EarlyErythroid7.5
CD8+_Tcells6.35
CardiacMyocytes15.5
Caudatenucleus7
Cerebellum6.1
CerebellumPeduncles9.2
CiliaryGanglion7.35
CingulateCortex8.2
Colorectaladenocarcinoma7.1
DorsalRootGanglion7.25
FetalThyroid7.9
Fetalbrain10.1
Fetalliver158.1
Fetallung12
GlobusPallidus5.9
Heart10.7
Hypothalamus16.95
Kidney26.85
Leukemia_chronicMyelogenousK-5626.4
Leukemia_promyelocytic-HL-606.2
Leukemialymphoblastic(MOLT-4)5.55
Liver14.8
Lung8.05
Lymphnode20.1
Lymphoma_burkitts(Daudi)9.85
Lymphoma_burkitts(Raji)11.55
MedullaOblongata6.6
OccipitalLobe6.8
OlfactoryBulb6.2
Ovary9.6
Pancreas6.9
PancreaticIslet18.7
ParietalLobe8.75
Pituitary9.7
Placenta7.5
Pons7.9
PrefrontalCortex9.35
Prostate21.8
Salivarygland6.8
SkeletalMuscle11.65
Skin7.5
SmoothMuscle8.95
Spinalcord34.5
SubthalamicNucleus6.9
SuperiorCervicalGanglion12.3
TemporalLobe7.15
Testis5.95
TestisGermCell6.2
TestisIntersitial6.9
TestisLeydigCell8.05
TestisSeminiferousTubule6.4
Thalamus8.15
Thymus5.5
Thyroid9.25
Tongue8.8
Tonsil8.15
Trachea11.5
TrigeminalGanglion10
Uterus162.3
UterusCorpus11.4
WholeBlood61.35
Wholebrain5.95
colon273.8
pineal_day11.86
pineal_night8.94
retina28.475
small_intestine75.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15507_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.58 ± 0.41
Basal Forebrain4.4 ± 0.21
Basal Part of Pons4.23 ± 0.4
Cerebellar Cortex4.46 ± 0.61
Cerebellar Nuclei4.31 ± 0.57
Claustrum4.34 ± 0.65
Epithalamus5.3 ± 0.71
Frontal Lobe4.53 ± 0.53
Globus Pallidus5.35 ± 0.43
Hypothalamus4.72 ± 0.8
Insula4.44 ± 0.74
Limbic Lobe4.9 ± 0.59
Mesencephalon4.79 ± 0.5
Myelencephalon4.61 ± 0.64
Occipital Lobe4.45 ± 0.61
Parietal Lobe4.63 ± 0.53
Pontine Tegmentum4.66 ± 0.6
Striatum4.66 ± 0.56
Subthalamus3.81 ± 0.16
Temporal Lobe4.7 ± 0.53
Thalamus4.35 ± 0.54
White Matter5.23 ± 0.35
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
HnmtCBCerebellum9.38
9.54
HnmtCTXCerebral cortex43.09
33.31
HnmtHIPHippocampal region25.63
29.49
HnmtHPFHippocampal formation31.07
31.96
HnmtHYHypothalamus20.3
16.28
HnmtLSXLateral septal complex2.67
1.98
HnmtMBMidbrain16.14
14.02
HnmtMYMedulla19.55
20.12
HnmtOLFOlfactory bulb57.88
49.08
HnmtPPons19.7
21.63
HnmtPALPallidum21.39
19.76
HnmtRHPRetrohippocampal region42.55
37.29
HnmtsAMYStriatum-like amygdalar nuclei34.18
26.66
HnmtSTRStriatum22.23
16.56
HnmtSTRdStriatum dorsal region17.96
12.99
HnmtSTRvStriatum ventral region41.97
30.18
HnmtTHThalamus10.48
7.93
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00002497 17 22 38 FLNHSTEHQCMQEFMDK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved