AutismKB 2.0

Annotation Detail for APBA2


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Basic Information Top
Gene Symbol:APBA2 ( D15S1518E,HsT16821,LIN-10,MGC99508,MGC:14091,MINT2,X11L )
Gene Full Name: amyloid beta (A4) precursor protein-binding, family A, member 2
Band: 15q13.1
Quick LinksEntrez ID:321; OMIM: 602712; Uniprot ID:APBA2_HUMAN; ENSEMBL ID: ENSG00000034053; HGNC ID: 579
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst2 / 6231932
fetus12 / 56401221
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult25 / 193912112
embryoid body2 / 7076128
blastocyst1 / 6231916
fetus15 / 56401226
neonate0 / 310970 
infant1 / 2362042
juvenile1 / 5555617
adult7 / 19391213
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor1 / 1729057
gastrointestinal tumor0 / 1193690 
germ cell tumor5 / 26384518
glioma7 / 10688365
head and neck tumor2 / 13630214
kidney tumor4 / 6895958
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor3 / 10312729
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal67 / 336030719
ovarian tumor1 / 7668213
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS16 / 125680127
prostate cancer1 / 1026809
retinoblastoma1 / 4635621
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor3 / 9025733
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor1 / 2638453
glioma4 / 10688337
head and neck tumor0 / 1363020 
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal41 / 336030712
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer0 / 1026800 
retinoblastoma1 / 4635621
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone0 / 716550 
bone marrow0 / 488010 
brain59 / 110098953
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue4 / 21572218
esophagus1 / 2020949
eye7 / 21105433
heart0 / 896260 
intestine0 / 2344720 
kidney5 / 21177723
larynx1 / 2414541
liver0 / 2077430 
lung3 / 3369748
lymph0 / 442700 
lymph node0 / 916100 
mammary gland1 / 1532716
mouth1 / 6705214
muscle1 / 1077159
nerve1 / 1576863
ovary3 / 10205129
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate1 / 1893455
salivary gland0 / 201550 
skin0 / 2105740 
spleen2 / 5395237
stomach0 / 966190 
testis4 / 33044212
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood2 / 12347816
bone0 / 716550 
bone marrow0 / 488010 
brain42 / 110098938
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye2 / 2110549
heart0 / 896260 
intestine1 / 2344724
kidney1 / 2117774
larynx0 / 241450 
liver0 / 2077430 
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen1 / 5395218
stomach0 / 966190 
testis3 / 3304429
thymus2 / 8113124
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus2 / 2328788
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209871_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.85
Adipocyte8.4
AdrenalCortex9.2
Adrenalgland7
Amygdala455.65
Appendix9.1
AtrioventricularNode6.35
BDCA4+_DentriticCells7.45
Bonemarrow8.55
BronchialEpithelialCells7.5
CD105+_Endothelial7.55
CD14+_Monocytes7.3
CD19+_BCells(neg._sel.)6.55
CD33+_Myeloid7.8
CD34+6.8
CD4+_Tcells125.9
CD56+_NKCells26.6
CD71+_EarlyErythroid6.55
CD8+_Tcells244.05
CardiacMyocytes11.05
Caudatenucleus51.95
Cerebellum250.85
CerebellumPeduncles370.05
CiliaryGanglion5.55
CingulateCortex294.4
Colorectaladenocarcinoma7.65
DorsalRootGanglion6.05
FetalThyroid7.4
Fetalbrain299.25
Fetalliver7.15
Fetallung6.95
GlobusPallidus183.9
Heart11.55
Hypothalamus243.2
Kidney6.6
Leukemia_chronicMyelogenousK-56210.65
Leukemia_promyelocytic-HL-606.15
Leukemialymphoblastic(MOLT-4)8.75
Liver12.05
Lung10.15
Lymphnode11.25
Lymphoma_burkitts(Daudi)10.95
Lymphoma_burkitts(Raji)11.5
MedullaOblongata265.7
OccipitalLobe299.5
OlfactoryBulb6.95
Ovary5.8
Pancreas6.3
PancreaticIslet9.4
ParietalLobe226.75
Pituitary9.2
Placenta8.25
Pons129.65
PrefrontalCortex709
Prostate9.65
Salivarygland6.95
SkeletalMuscle9.45
Skin6
SmoothMuscle9.2
Spinalcord78.9
SubthalamicNucleus210.7
SuperiorCervicalGanglion9.9
TemporalLobe187.75
Testis8.45
TestisGermCell7.1
TestisIntersitial7.45
TestisLeydigCell8.5
TestisSeminiferousTubule8.3
Thalamus149.2
Thymus7.55
Thyroid10.8
Tongue8.35
Tonsil8.3
Trachea7
TrigeminalGanglion8.05
Uterus6.3
UterusCorpus11.4
WholeBlood9.2
Wholebrain667
colon7.8
pineal_day12.58
pineal_night10.34
retina49.6
small_intestine7.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P146849
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.77 ± 0.75
Basal Forebrain6.78 ± 0.54
Basal Part of Pons7.97 ± 0.4
Cerebellar Cortex7.79 ± 0.29
Cerebellar Nuclei7.03 ± 0.61
Claustrum6.89 ± 0.61
Epithalamus6.75 ± 0.62
Frontal Lobe7.52 ± 0.54
Globus Pallidus6.18 ± 0.37
Hypothalamus6.91 ± 0.93
Insula7.6 ± 0.39
Limbic Lobe7.41 ± 0.77
Mesencephalon6.99 ± 0.62
Myelencephalon7.12 ± 0.79
Occipital Lobe6.79 ± 0.81
Parietal Lobe7.35 ± 0.64
Pontine Tegmentum7.07 ± 0.57
Striatum5.68 ± 0.77
Subthalamus8.1 ± 1.26
Temporal Lobe7.56 ± 0.52
Thalamus7.15 ± 0.47
White Matter6.07 ± 0.5
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Apba2CBCerebellum100
100
Apba2CTXCerebral cortex100
100
Apba2HIPHippocampal region95.8
100
Apba2HPFHippocampal formation100
100
Apba2HYHypothalamus100
93.54
Apba2LSXLateral septal complex100
100
Apba2MBMidbrain93.69
94.95
Apba2MYMedulla100
100
Apba2OLFOlfactory bulb100
100
Apba2PPons99.04
100
Apba2PALPallidum98.66
100
Apba2RHPRetrohippocampal region100
100
Apba2sAMYStriatum-like amygdalar nuclei100
100
Apba2STRStriatum67.5
54.18
Apba2STRdStriatum dorsal region40.59
32.67
Apba2STRvStriatum ventral region97.6
66.42
Apba2THThalamus100
100
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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