AutismKB 2.0

Annotation Detail for APBB1


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Basic Information Top
Gene Symbol:APBB1 ( FE65,MGC:9072,RIR )
Gene Full Name: amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
Band: 11p15.4
Quick LinksEntrez ID:322; OMIM: 602709; Uniprot ID:APBB1_HUMAN; ENSEMBL ID: ENSG00000166313; HGNC ID: 581
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst7 / 62319112
fetus61 / 564012108
neonate1 / 3109732
infant11 / 23620465
juvenile4 / 5555671
adult116 / 193912159
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma6 / 8282372
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor6 / 11936950
germ cell tumor16 / 26384560
glioma16 / 106883149
head and neck tumor2 / 13630214
kidney tumor6 / 6895987
leukemia8 / 9584283
liver tumor3 / 9635931
lung tumor6 / 10312758
lymphoma2 / 7175527
non-neoplasia7 / 9725071
normal318 / 336030794
ovarian tumor2 / 7668226
pancreatic tumor12 / 104616114
primitive neuroectodermal tumor of the CNS6 / 12568047
prostate cancer0 / 1026800 
retinoblastoma3 / 4635664
skin tumor10 / 12494980
soft tissue/muscle tissue tumor7 / 12519155
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites1 / 4001524
bladder0 / 297570 
blood12 / 12347897
bone5 / 7165569
bone marrow3 / 4880161
brain253 / 1100989229
cervix0 / 481710 
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue10 / 21572246
esophagus0 / 202090 
eye28 / 211054132
heart1 / 8962611
intestine0 / 2344720 
kidney9 / 21177742
larynx1 / 2414541
liver3 / 20774314
lung14 / 33697441
lymph2 / 4427045
lymph node5 / 9161054
mammary gland3 / 15327119
mouth0 / 670520 
muscle11 / 107715102
nerve4 / 15768253
ovary7 / 10205168
pancreas20 / 21481293
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland4 / 16585241
placenta1 / 2808253
prostate2 / 18934510
salivary gland1 / 2015549
skin14 / 21057466
spleen0 / 539520 
stomach5 / 9661951
testis10 / 33044230
thymus5 / 8113161
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus16 / 23287868
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202652_at
Cell line Expression level Expression bar
721_B_lymphoblasts17.5
Adipocyte23.7
AdrenalCortex31.3
Adrenalgland25.7
Amygdala53.5
Appendix24.6
AtrioventricularNode37.95
BDCA4+_DentriticCells12.75
Bonemarrow21.25
BronchialEpithelialCells15.6
CD105+_Endothelial11
CD14+_Monocytes8.05
CD19+_BCells(neg._sel.)23.25
CD33+_Myeloid13.85
CD34+15.4
CD4+_Tcells50.65
CD56+_NKCells24.95
CD71+_EarlyErythroid23.1
CD8+_Tcells30.4
CardiacMyocytes31.6
Caudatenucleus79.4
Cerebellum106.15
CerebellumPeduncles197.35
CiliaryGanglion19
CingulateCortex177.05
Colorectaladenocarcinoma14.6
DorsalRootGanglion20.6
FetalThyroid26.9
Fetalbrain69.4
Fetalliver17.4
Fetallung17.15
GlobusPallidus127.9
Heart27.85
Hypothalamus89
Kidney20.85
Leukemia_chronicMyelogenousK-56219.8
Leukemia_promyelocytic-HL-6011
Leukemialymphoblastic(MOLT-4)18.2
Liver27.1
Lung29.9
Lymphnode19.3
Lymphoma_burkitts(Daudi)24.85
Lymphoma_burkitts(Raji)24.95
MedullaOblongata86
OccipitalLobe148.5
OlfactoryBulb32.05
Ovary15.6
Pancreas17.85
PancreaticIslet26.15
ParietalLobe125.7
Pituitary42.4
Placenta21.15
Pons96.35
PrefrontalCortex130.4
Prostate20
Salivarygland16.25
SkeletalMuscle36.1
Skin18.1
SmoothMuscle22.9
Spinalcord89
SubthalamicNucleus123.95
SuperiorCervicalGanglion26.05
TemporalLobe143.05
Testis19.2
TestisGermCell16.95
TestisIntersitial17.9
TestisLeydigCell23.1
TestisSeminiferousTubule19.45
Thalamus187.2
Thymus20.5
Thyroid26.8
Tongue25.15
Tonsil20.6
Trachea17.9
TrigeminalGanglion41
Uterus19.35
UterusCorpus24.75
WholeBlood22.2
Wholebrain167.95
colon20.45
pineal_day50.22
pineal_night38.6
retina46.05
small_intestine19.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P372613
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.72 ± 0.81
Basal Forebrain7.11 ± 0.47
Basal Part of Pons7.96 ± 0.56
Cerebellar Cortex7.94 ± 0.44
Cerebellar Nuclei7.23 ± 0.51
Claustrum6.89 ± 0.77
Epithalamus7.11 ± 0.89
Frontal Lobe7.75 ± 0.53
Globus Pallidus6.71 ± 0.21
Hypothalamus7.71 ± 0.38
Insula7.79 ± 0.4
Limbic Lobe7.28 ± 0.64
Mesencephalon7.34 ± 0.48
Myelencephalon7.41 ± 0.65
Occipital Lobe6.68 ± 0.67
Parietal Lobe7.38 ± 0.58
Pontine Tegmentum7.24 ± 0.55
Striatum6.35 ± 0.46
Subthalamus7.24 ± 0.57
Temporal Lobe7.67 ± 0.52
Thalamus7.4 ± 0.53
White Matter7.73 ± 0.53
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Apbb1CBCerebellum50
50
Apbb1CTXCerebral cortex50
50
Apbb1HIPHippocampal region50
50
Apbb1HPFHippocampal formation50
50
Apbb1HYHypothalamus50
50
Apbb1LSXLateral septal complex50
50
Apbb1MBMidbrain50
50
Apbb1MYMedulla50
50
Apbb1OLFOlfactory bulb50
50
Apbb1PPons50
50
Apbb1PALPallidum50
50
Apbb1RHPRetrohippocampal region50
50
Apbb1sAMYStriatum-like amygdalar nuclei50
50
Apbb1STRStriatum50
50
Apbb1STRdStriatum dorsal region50
50
Apbb1STRvStriatum ventral region50
50
Apbb1THThalamus50
50
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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