AutismKB 2.0

Annotation Detail for HOXD1


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Basic Information Top
Gene Symbol:HOXD1 ( HOX4,HOX4G,Hox-4.7 )
Gene Full Name: homeobox D1
Band: 2q31.1
Quick LinksEntrez ID:3231; OMIM: 142987; Uniprot ID:HXD1_HUMAN; ENSEMBL ID: ENSG00000128645; HGNC ID: 5132
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus6 / 56401210
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult8 / 19391214
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor2 / 2638457
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia1 / 9584210
liver tumor1 / 9635910
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal27 / 33603078
ovarian tumor0 / 766820 
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain8 / 11009897
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart2 / 8962622
intestine1 / 2344724
kidney11 / 21177751
larynx0 / 241450 
liver1 / 2077434
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin5 / 21057423
spleen1 / 5395218
stomach0 / 966190 
testis2 / 3304426
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205975_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.25
Adipocyte6.65
AdrenalCortex7.9
Adrenalgland6.15
Amygdala7.1
Appendix7.9
AtrioventricularNode5.5
BDCA4+_DentriticCells6.3
Bonemarrow6.6
BronchialEpithelialCells6.7
CD105+_Endothelial6.85
CD14+_Monocytes7.15
CD19+_BCells(neg._sel.)7.15
CD33+_Myeloid8.45
CD34+8.25
CD4+_Tcells7.25
CD56+_NKCells8.05
CD71+_EarlyErythroid6.15
CD8+_Tcells6.55
CardiacMyocytes8.35
Caudatenucleus6
Cerebellum5.4
CerebellumPeduncles7.9
CiliaryGanglion6.25
CingulateCortex9.35
Colorectaladenocarcinoma6.65
DorsalRootGanglion7.75
FetalThyroid6.65
Fetalbrain6.75
Fetalliver5.75
Fetallung5.25
GlobusPallidus4.9
Heart8.4
Hypothalamus7.45
Kidney5.6
Leukemia_chronicMyelogenousK-5626.1
Leukemia_promyelocytic-HL-605.9
Leukemialymphoblastic(MOLT-4)5.4
Liver9.2
Lung7.5
Lymphnode5.75
Lymphoma_burkitts(Daudi)8.65
Lymphoma_burkitts(Raji)9.25
MedullaOblongata6.2
OccipitalLobe6.05
OlfactoryBulb5.3
Ovary4.65
Pancreas6.25
PancreaticIslet6.95
ParietalLobe7
Pituitary7.5
Placenta6.3
Pons7.55
PrefrontalCortex7.45
Prostate8.1
Salivarygland5.35
SkeletalMuscle7.95
Skin5.65
SmoothMuscle7.7
Spinalcord9.35
SubthalamicNucleus6.15
SuperiorCervicalGanglion9.7
TemporalLobe6.5
Testis5.75
TestisGermCell5.55
TestisIntersitial5.75
TestisLeydigCell7
TestisSeminiferousTubule6.15
Thalamus6.9
Thymus5.4
Thyroid8.45
Tongue7.2
Tonsil6.5
Trachea5.6
TrigeminalGanglion11.15
Uterus5.5
UterusCorpus5.9
WholeBlood6.95
Wholebrain5.9
colon7.85
pineal_day8
pineal_night7.8
retina8.525
small_intestine6.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_1264_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.09 ± 0.89
Basal Forebrain5.89 ± 0.57
Basal Part of Pons5.69 ± 0.8
Cerebellar Cortex5.07 ± 0.64
Cerebellar Nuclei6.53 ± 0.55
Claustrum5.74 ± 0.69
Epithalamus4.75 ± 0.96
Frontal Lobe5.4 ± 0.7
Globus Pallidus6.79 ± 0.58
Hypothalamus5.31 ± 0.39
Insula4.85 ± 0.83
Limbic Lobe5.27 ± 0.77
Mesencephalon5.5 ± 0.62
Myelencephalon5.57 ± 0.77
Occipital Lobe5.56 ± 0.95
Parietal Lobe5.37 ± 0.72
Pontine Tegmentum5.47 ± 0.68
Striatum5.76 ± 0.64
Subthalamus5.87 ± 0.17
Temporal Lobe5.19 ± 0.75
Thalamus5.65 ± 0.55
White Matter8.13 ± 0.6
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Hoxd1CBCerebellum33.99
48.59
Hoxd1CTXCerebral cortex25.01
17.35
Hoxd1HIPHippocampal region13.32
12.25
Hoxd1HPFHippocampal formation18.05
16.01
Hoxd1HYHypothalamus0.7
0.48
Hoxd1LSXLateral septal complex0.52
0.46
Hoxd1MBMidbrain10.14
8.35
Hoxd1MYMedulla8.26
7.82
Hoxd1OLFOlfactory bulb25.93
21.81
Hoxd1PPons6.24
5.94
Hoxd1PALPallidum3.98
4.99
Hoxd1RHPRetrohippocampal region26.8
22.14
Hoxd1sAMYStriatum-like amygdalar nuclei18.17
13.66
Hoxd1STRStriatum8.53
5.97
Hoxd1STRdStriatum dorsal region8.63
6.1
Hoxd1STRvStriatum ventral region5.67
3.28
Hoxd1THThalamus4.09
3.09
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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