AutismKB 2.0

Annotation Detail for HOXD3


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Basic Information Top
Gene Symbol:HOXD3 ( HOX1D,HOX4,HOX4A,Hox-4.1,MGC10470 )
Gene Full Name: homeobox D3
Band: 2q31.1
Quick LinksEntrez ID:3232; OMIM: 142980; Uniprot ID:HXD3_HUMAN; ENSEMBL ID: ENSG00000128652; HGNC ID: 5137
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus0 / 5640120 
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult2 / 19391211
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal14 / 33603074
ovarian tumor2 / 7668226
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain1 / 11009890 
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine0 / 2344720 
kidney14 / 21177766
larynx0 / 241450 
liver0 / 2077430 
lung1 / 3369742
lymph0 / 442700 
lymph node0 / 916100 
mammary gland1 / 1532716
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary2 / 10205119
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate1 / 1893455
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus1 / 2328784
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 206602_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.05
Adipocyte3.2
AdrenalCortex3.35
Adrenalgland2.7
Amygdala3.4
Appendix3.25
AtrioventricularNode2.4
BDCA4+_DentriticCells3.6
Bonemarrow3.15
BronchialEpithelialCells3.2
CD105+_Endothelial3.25
CD14+_Monocytes3.4
CD19+_BCells(neg._sel.)3.45
CD33+_Myeloid4.2
CD34+4.15
CD4+_Tcells3.5
CD56+_NKCells3.85
CD71+_EarlyErythroid3
CD8+_Tcells3.1
CardiacMyocytes4.1
Caudatenucleus2.9
Cerebellum2.6
CerebellumPeduncles3.6
CiliaryGanglion2.45
CingulateCortex3.25
Colorectaladenocarcinoma3.25
DorsalRootGanglion2.4
FetalThyroid3.15
Fetalbrain3.25
Fetalliver2.8
Fetallung2.7
GlobusPallidus2.35
Heart4.1
Hypothalamus3.55
Kidney2.65
Leukemia_chronicMyelogenousK-5622.95
Leukemia_promyelocytic-HL-602.8
Leukemialymphoblastic(MOLT-4)2.6
Liver4.25
Lung3.6
Lymphnode2.8
Lymphoma_burkitts(Daudi)4.1
Lymphoma_burkitts(Raji)4.5
MedullaOblongata2.95
OccipitalLobe2.9
OlfactoryBulb2.5
Ovary2.1
Pancreas2.6
PancreaticIslet3.45
ParietalLobe3.4
Pituitary3.8
Placenta3.35
Pons3.05
PrefrontalCortex4.1
Prostate3.8
Salivarygland2.6
SkeletalMuscle3.8
Skin2.45
SmoothMuscle3.7
Spinalcord3.45
SubthalamicNucleus2.95
SuperiorCervicalGanglion3.95
TemporalLobe2.9
Testis2.8
TestisGermCell2.7
TestisIntersitial2.7
TestisLeydigCell3.15
TestisSeminiferousTubule2.75
Thalamus3.25
Thymus2.55
Thyroid4.05
Tongue3.15
Tonsil3.15
Trachea2.7
TrigeminalGanglion3.15
Uterus2.65
UterusCorpus2.85
WholeBlood3.55
Wholebrain2.8
colon3.25
pineal_day4.04
pineal_night3.92
retina3.9
small_intestine3.2
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16149_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala1.98 ± 1.05
Basal Forebrain1.63 ± 0.16
Basal Part of Pons1.68 ± 0.72
Cerebellar Cortex1.39 ± 0.69
Cerebellar Nuclei1.76 ± 0.76
Claustrum2.58 ± 1.1
Epithalamus1.35 ± 0.89
Frontal Lobe1.46 ± 0.69
Globus Pallidus2.2 ± 0.53
Hypothalamus1.67 ± 0.72
Insula1.47 ± 0.53
Limbic Lobe1.58 ± 0.67
Mesencephalon1.67 ± 0.76
Myelencephalon1.81 ± 0.68
Occipital Lobe1.77 ± 0.75
Parietal Lobe1.53 ± 0.77
Pontine Tegmentum1.44 ± 0.7
Striatum1.74 ± 0.54
Subthalamus1.61 ± 0.65
Temporal Lobe1.54 ± 0.78
Thalamus1.58 ± 0.63
White Matter2.06 ± 0.48
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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