AutismKB 2.0

Annotation Detail for HOXD8


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Basic Information Top
Gene Symbol:HOXD8 ( HOX4,HOX4E,HOX5.4 )
Gene Full Name: homeobox D8
Band: 2q31.1
Quick LinksEntrez ID:3234; OMIM: 142985; Uniprot ID:HXD8_HUMAN; ENSEMBL ID: ENSG00000175879; HGNC ID: 5139
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus3 / 5640125
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult5 / 19391212
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor3 / 26384511
glioma1 / 1068839
head and neck tumor0 / 1363020 
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal13 / 33603073
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain1 / 11009890 
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart2 / 8962622
intestine0 / 2344720 
kidney6 / 21177728
larynx0 / 241450 
liver0 / 2077430 
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland2 / 15327113
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin2 / 2105749
spleen0 / 539520 
stomach0 / 966190 
testis2 / 3304426
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: Primary tumors (U95A)
  • Affymatrix Probe ID: 696_at
Cell line Expression level Expression bar
Pr1T4.774
Pr4T8.019
Pr5T5.644
Pr7T5.204
Pr1N6.107
Pr5N5.22
Pr6T6.993
Pr3N5.468
Pr3T6.07
Pr4N5.848
Pr2N5.588
Pr8N5.988
Pr8T6.393
Pr9N4.906
Pr10N5.828
Pr10T6.249
Pr9T5.169
Pr11T6.134
Pr12T5.676
Pr13AT6.13
Pr13BT5.585
Pr21T6.594
Pr22T5.953
Pr30T6.767
Pr23T6.627
Pr19T6.251
Pr26T6.122
Pr31T5.707
Pr16T6.269
Pr17T6.244
Pr24T5.166
Pr27T5.439
Pr29T4.433
OVR10233.834
HUOVR6.236
G26.86
G36.095
G55.718
G65.79
G85.05
G96.095
CO7T6.748
CO8T5.918
CO15T6.757
CO27T6.613
CO30T6.788
CO32T6.328
CO40T6.314
CO52N7.711
CO62N7.348
K113.639
K25.996
K315.11
K46.247
K14N329.009
K1610.826
K178.868
K1914.639
K206.359
K2210.545
CO9T6.186
CO20T7.021
CO24T6.713
CO36N6.954
K187.167
P1N4.898
P2N6.48
P5N6.741
P86.127
P114.262
P175.788
K216.513
K25N60.523
K28N8.122
CO42T6.604
P224.428
P13N6.04
LU11T5.829
LU16T7.226
LU7T6.199
LU8T5.958
LU12T6.348
LU13T6.362
LU5T6.532
LU6T9.286
LU14T6.592
LU17T6.649
LU50N5.774
LU52N6.567
LU18T6.322
LU55N6.382
LU3N6.781
P16B7.079
P235.796
OVR1623.97
OVR1916.467
OVR279.383
OVR285.507
OVR278E17.747
OVR26.164
OVR55.547
OVR86.096
OVR116.732
OVR126.447
OVR1328.164
OVR226.599
OVR266.593
OVR107.107
OVR278S7.894
OVR17.39
LU19T6.224
LU20T6.801
LU24T6.359
LU25T7.236
LU31T7.107
LU34T6.613
LU39T5.454
CO14T6.675
CO21T7.185
CO23T7.141
CO41N6.078
LU40T6.892
LU41T5.864
LU44T6.497
LU46T5.976
LU49T6.474
L5N6.563
LU42T6.533
LU30T6.571
LU43T9.298
CO5T6.489
CO44T7.294
CO49T6.501
CO51T6.871
CO56T6.127
CO61T6.901
LU26T6.588
LU33T7.146
LU36T6.144
CO43T6.766
G186.879
G466.03
L11T7.06
L13N6.735
L30T7.033
L31T7.078
L32T7.253
L34T7.416
L35T7.626
B1N7.051
B5N6.397
B8T6.417
B10T6.338
B14T7.215
B16T6.43
B17T7.648
B1NR6.803
B20T11.076
B51NR7.729
B6T8.419
B15T7.399
B21T27.228
B29T7.191
B31T8.639
B32T11.551
B24T6.27
B46T6.159
B34T8.167
B36T6.592
B37T6.926
B38T8.782
B39T5.99
X10210.76
X116_026.594
G2805.607
X465.877
X589.338
G1866.782
G29625.48
L38T6.539
L31T.26.112
L26N6.931
N257ANTR6.484
N285BODY5.284
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_2318_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.73 ± 0.55
Basal Forebrain3.6 ± 0.51
Basal Part of Pons3.93 ± 0.8
Cerebellar Cortex3.38 ± 0.86
Cerebellar Nuclei3.67 ± 0.74
Claustrum3.82 ± 0.89
Epithalamus3.42 ± 0.44
Frontal Lobe3.75 ± 0.81
Globus Pallidus4.14 ± 0.45
Hypothalamus3.15 ± 0.58
Insula3.45 ± 0.72
Limbic Lobe3.96 ± 0.88
Mesencephalon3.66 ± 0.81
Myelencephalon3.81 ± 0.81
Occipital Lobe3.71 ± 0.78
Parietal Lobe3.6 ± 0.8
Pontine Tegmentum3.41 ± 0.68
Striatum3.91 ± 0.64
Subthalamus3.5 ± 0.26
Temporal Lobe3.64 ± 0.87
Thalamus3.82 ± 0.73
White Matter4.42 ± 0.32
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Hoxd8CBCerebellum1.51
1.82
Hoxd8CTXCerebral cortex0.62
0.62
Hoxd8HIPHippocampal region0.41
0.59
Hoxd8HPFHippocampal formation0.43
0.64
Hoxd8HYHypothalamus0.08
0.26
Hoxd8LSXLateral septal complex0.3
0.71
Hoxd8MBMidbrain0.29
0.62
Hoxd8MYMedulla0.63
0.61
Hoxd8OLFOlfactory bulb2.07
2.04
Hoxd8PPons0.23
0.27
Hoxd8PALPallidum0.17
0.14
Hoxd8RHPRetrohippocampal region0.4
0.64
Hoxd8sAMYStriatum-like amygdalar nuclei0.52
0.41
Hoxd8STRStriatum0.3
0.37
Hoxd8STRdStriatum dorsal region0.28
0.35
Hoxd8STRvStriatum ventral region0.27
0.3
Hoxd8THThalamus0.2
0.28
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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