AutismKB 2.0

Annotation Detail for HES1


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Basic Information Top
Gene Symbol:HES1 ( FLJ20408,HES-1,HHL,HRY,bHLHb39 )
Gene Full Name: hairy and enhancer of split 1, (Drosophila)
Band: 3q29
Quick LinksEntrez ID:3280; OMIM: 139605; Uniprot ID:HES1_HUMAN; ENSEMBL ID: ENSG00000114315; HGNC ID: 5192
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst3 / 6231948
fetus46 / 56401281
neonate1 / 3109732
infant0 / 236200 
juvenile3 / 5555653
adult103 / 193912153
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor1 / 1142468
esophageal tumor1 / 1729057
gastrointestinal tumor16 / 119369134
germ cell tumor3 / 26384511
glioma5 / 10688346
head and neck tumor3 / 13630222
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal326 / 336030797
ovarian tumor1 / 7668213
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer4 / 10268038
retinoblastoma0 / 463560 
skin tumor5 / 12494940
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites4 / 4001599
bladder2 / 2975767
blood2 / 12347816
bone2 / 7165527
bone marrow0 / 488010 
brain25 / 110098922
cervix0 / 481710 
connective tissue4 / 14925526
ear1 / 1621261
embryonic tissue12 / 21572255
esophagus1 / 2020949
eye31 / 211054146
heart2 / 8962622
intestine7 / 23447229
kidney5 / 21177723
larynx0 / 241450 
liver154 / 207743741
lung15 / 33697444
lymph0 / 442700 
lymph node5 / 9161054
mammary gland3 / 15327119
mouth1 / 6705214
muscle2 / 10771518
nerve3 / 15768190
ovary1 / 1020519
pancreas13 / 21481260
parathyroid5 / 20539243
pharynx1 / 4132824
pituitary gland3 / 16585180
placenta16 / 28082556
prostate16 / 18934584
salivary gland0 / 201550 
skin6 / 21057428
spleen1 / 5395218
stomach9 / 9661993
testis5 / 33044215
thymus1 / 8113112
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord1 / 1368073
uterus6 / 23287825
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203393_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.6
Adipocyte7.1
AdrenalCortex8.6
Adrenalgland6
Amygdala7.75
Appendix11
AtrioventricularNode5.95
BDCA4+_DentriticCells6.75
Bonemarrow7.3
BronchialEpithelialCells6.6
CD105+_Endothelial6.85
CD14+_Monocytes7.2
CD19+_BCells(neg._sel.)7.2
CD33+_Myeloid8.35
CD34+8.1
CD4+_Tcells6.9
CD56+_NKCells7.55
CD71+_EarlyErythroid6.45
CD8+_Tcells5.8
CardiacMyocytes13.3
Caudatenucleus6.25
Cerebellum5.75
CerebellumPeduncles8.25
CiliaryGanglion8.85
CingulateCortex8.85
Colorectaladenocarcinoma6.8
DorsalRootGanglion5.85
FetalThyroid6.8
Fetalbrain7
Fetalliver5.9
Fetallung5
GlobusPallidus8.6
Heart9.85
Hypothalamus11.3
Kidney6.2
Leukemia_chronicMyelogenousK-5626.2
Leukemia_promyelocytic-HL-606.2
Leukemialymphoblastic(MOLT-4)5.25
Liver12.95
Lung7.5
Lymphnode5.85
Lymphoma_burkitts(Daudi)8.8
Lymphoma_burkitts(Raji)11.75
MedullaOblongata6.45
OccipitalLobe6.3
OlfactoryBulb5.45
Ovary5.5
Pancreas6.65
PancreaticIslet8.2
ParietalLobe7.55
Pituitary8.3
Placenta6.8
Pons8.65
PrefrontalCortex8.05
Prostate8.05
Salivarygland5.6
SkeletalMuscle15.1
Skin6.35
SmoothMuscle7.7
Spinalcord8.35
SubthalamicNucleus6.4
SuperiorCervicalGanglion14.7
TemporalLobe6.6
Testis6.05
TestisGermCell5.6
TestisIntersitial6.05
TestisLeydigCell8.15
TestisSeminiferousTubule6
Thalamus6.95
Thymus5.45
Thyroid8.25
Tongue8.5
Tonsil6.75
Trachea5.75
TrigeminalGanglion12.9
Uterus5.4
UterusCorpus6.95
WholeBlood7.25
Wholebrain5.85
colon7.1
pineal_day8.12
pineal_night7.96
retina8
small_intestine6.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P938293
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.84 ± 0.24
Basal Forebrain9.04 ± 0.45
Basal Part of Pons8.67 ± 0.36
Cerebellar Cortex8.52 ± 0.17
Cerebellar Nuclei9.36 ± 0.4
Claustrum8.72 ± 0.36
Epithalamus10.14 ± 0.58
Frontal Lobe8.86 ± 0.4
Globus Pallidus9.97 ± 0.22
Hypothalamus8.98 ± 0.74
Insula8.88 ± 0.28
Limbic Lobe8.76 ± 0.37
Mesencephalon8.88 ± 0.28
Myelencephalon8.9 ± 0.39
Occipital Lobe8.85 ± 0.4
Parietal Lobe8.61 ± 0.37
Pontine Tegmentum8.86 ± 0.47
Striatum9.39 ± 0.47
Subthalamus8.77 ± 0.29
Temporal Lobe8.73 ± 0.34
Thalamus8.88 ± 0.27
White Matter9.09 ± 0.89
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Hes1CBCerebellum58.66
65.46
Hes1CTXCerebral cortex100
80.39
Hes1HIPHippocampal region73.59
83.51
Hes1HPFHippocampal formation83.69
86.45
Hes1HYHypothalamus62.96
46.03
Hes1LSXLateral septal complex54.42
33.46
Hes1MBMidbrain46.29
42.44
Hes1MYMedulla66.66
74.93
Hes1OLFOlfactory bulb100
81.14
Hes1PPons61.47
64.7
Hes1PALPallidum58.69
53.55
Hes1RHPRetrohippocampal region98.55
88.81
Hes1sAMYStriatum-like amygdalar nuclei76.29
51.74
Hes1STRStriatum40.81
26.72
Hes1STRdStriatum dorsal region27.02
18.01
Hes1STRvStriatum ventral region62.28
37.57
Hes1THThalamus53.47
47.02
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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