AutismKB 2.0

Annotation Detail for BIRC3


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Basic Information Top
Gene Symbol:BIRC3 ( AIP1,API2,CIAP2,HAIP1,HIAP1,MALT2,MIHC,RNF49,c-IAP2 )
Gene Full Name: baculoviral IAP repeat-containing 3
Band: 11q22.2
Quick LinksEntrez ID:330; OMIM: 601721; Uniprot ID:BIRC3_HUMAN; ENSEMBL ID: ENSG00000023445; HGNC ID: 591
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus16 / 56401228
neonate0 / 310970 
infant1 / 2362042
juvenile3 / 5555653
adult82 / 193912142
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor18 / 114246157
esophageal tumor1 / 1729057
gastrointestinal tumor1 / 1193698
germ cell tumor3 / 26384511
glioma6 / 10688356
head and neck tumor2 / 13630214
kidney tumor3 / 6895943
leukemia4 / 9584241
liver tumor5 / 9635951
lung tumor2 / 10312719
lymphoma12 / 71755167
non-neoplasia4 / 9725041
normal159 / 336030747
ovarian tumor1 / 7668213
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor8 / 9025788
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder2 / 2975767
blood29 / 123478234
bone1 / 7165513
bone marrow0 / 488010 
brain8 / 11009897
cervix0 / 481710 
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus1 / 2020949
eye1 / 2110544
heart0 / 896260 
intestine24 / 234472102
kidney19 / 21177789
larynx0 / 241450 
liver7 / 20774333
lung24 / 33697471
lymph8 / 44270180
lymph node25 / 91610272
mammary gland9 / 15327158
mouth1 / 6705214
muscle6 / 10771555
nerve2 / 15768126
ovary2 / 10205119
pancreas4 / 21481218
parathyroid3 / 20539146
pharynx15 / 41328362
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate4 / 18934521
salivary gland0 / 201550 
skin5 / 21057423
spleen0 / 539520 
stomach1 / 9661910
testis2 / 3304426
thymus2 / 8113124
thyroid2 / 4747342
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus12 / 23287851
vascular6 / 51780115
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210538_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts513.8
Adipocyte8.05
AdrenalCortex12.5
Adrenalgland7.6
Amygdala8.2
Appendix11.5
AtrioventricularNode7.65
BDCA4+_DentriticCells9.45
Bonemarrow9.9
BronchialEpithelialCells7.9
CD105+_Endothelial8.5
CD14+_Monocytes9.3
CD19+_BCells(neg._sel.)1161.15
CD33+_Myeloid11
CD34+10.45
CD4+_Tcells59.3
CD56+_NKCells12.05
CD71+_EarlyErythroid8
CD8+_Tcells21.6
CardiacMyocytes14.45
Caudatenucleus7.8
Cerebellum6.8
CerebellumPeduncles11
CiliaryGanglion8
CingulateCortex8.95
Colorectaladenocarcinoma8.45
DorsalRootGanglion9.15
FetalThyroid8.5
Fetalbrain8.3
Fetalliver7.5
Fetallung12.5
GlobusPallidus6.7
Heart12.2
Hypothalamus8.55
Kidney7.45
Leukemia_chronicMyelogenousK-5627.4
Leukemia_promyelocytic-HL-60278.65
Leukemialymphoblastic(MOLT-4)6.75
Liver14.1
Lung8.65
Lymphnode183.2
Lymphoma_burkitts(Daudi)69.35
Lymphoma_burkitts(Raji)363.6
MedullaOblongata7.3
OccipitalLobe7.2
OlfactoryBulb6.9
Ovary6.3
Pancreas8.95
PancreaticIslet32.65
ParietalLobe9.65
Pituitary9.75
Placenta8.1
Pons8.4
PrefrontalCortex9.85
Prostate9.55
Salivarygland9.75
SkeletalMuscle15.35
Skin12.85
SmoothMuscle9.6
Spinalcord8.95
SubthalamicNucleus8.35
SuperiorCervicalGanglion15.55
TemporalLobe8.1
Testis7.05
TestisGermCell7.15
TestisIntersitial7.65
TestisLeydigCell9.25
TestisSeminiferousTubule7.35
Thalamus8.75
Thymus7.15
Thyroid9.95
Tongue10.1
Tonsil49.65
Trachea6.95
TrigeminalGanglion12.45
Uterus7.5
UterusCorpus9.65
WholeBlood23.1
Wholebrain6.4
colon8.7
pineal_day10.44
pineal_night10.26
retina10.05
small_intestine8.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16193_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.79 ± 0.71
Basal Forebrain3.56 ± 0.4
Basal Part of Pons3.32 ± 0.37
Cerebellar Cortex3.05 ± 0.49
Cerebellar Nuclei3.54 ± 0.69
Claustrum3.87 ± 0.5
Epithalamus3.09 ± 0.76
Frontal Lobe3.76 ± 0.66
Globus Pallidus3.29 ± 0.71
Hypothalamus3.72 ± 0.47
Insula4.16 ± 0.81
Limbic Lobe4.27 ± 0.68
Mesencephalon3.64 ± 0.88
Myelencephalon3.66 ± 0.7
Occipital Lobe3.15 ± 1.01
Parietal Lobe3.53 ± 0.76
Pontine Tegmentum3.78 ± 0.7
Striatum3.82 ± 0.96
Subthalamus3.42 ± 0.8
Temporal Lobe3.98 ± 0.67
Thalamus3.35 ± 0.78
White Matter4.27 ± 0.48
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Birc3CBCerebellum0.23
0.32
Birc3CTXCerebral cortex0.18
0.19
Birc3HIPHippocampal region0.17
0.18
Birc3HPFHippocampal formation0.16
0.17
Birc3HYHypothalamus0.15
0.09
Birc3LSXLateral septal complex0.06
0
Birc3MBMidbrain0.16
0.33
Birc3MYMedulla0.27
0.35
Birc3OLFOlfactory bulb0.29
0.33
Birc3PPons0.27
0.18
Birc3PALPallidum0.15
0.14
Birc3RHPRetrohippocampal region0.16
0.17
Birc3sAMYStriatum-like amygdalar nuclei0.05
0.1
Birc3STRStriatum0.13
0.1
Birc3STRdStriatum dorsal region0.14
0.11
Birc3STRvStriatum ventral region0.14
0.09
Birc3THThalamus0.14
0.18
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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