AutismKB 2.0

Annotation Detail for HSPA1A


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Basic Information Top
Gene Symbol:HSPA1A ( FLJ54303,FLJ54370,FLJ54392,FLJ54408,FLJ75127,HSP70-1,HSP70-1A,HSP70I,HSP72,HSPA1,HSPA1B )
Gene Full Name: heat shock 70kDa protein 1A
Band: 6p21.33
Quick LinksEntrez ID:3303; OMIM: 140550; Uniprot ID:HSP71_HUMAN; ENSEMBL ID: ENSG00000204389; HGNC ID: 5232
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst1 / 6231916
fetus310 / 564012549
neonate13 / 31097418
infant3 / 23620127
juvenile31 / 55556557
adult262 / 1939121135
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma6 / 17475343
breast (mammary gland) tumor68 / 94178722
cervical tumor4 / 34366116
chondrosarcoma14 / 82823169
colorectal tumor3 / 11424626
esophageal tumor53 / 172903065
gastrointestinal tumor11 / 11936992
germ cell tumor35 / 263845132
glioma12 / 106883112
head and neck tumor69 / 136302506
kidney tumor27 / 68959391
leukemia18 / 95842187
liver tumor27 / 96359280
lung tumor12 / 103127116
lymphoma0 / 717550 
non-neoplasia51 / 97250524
normal2692 / 3360307801
ovarian tumor1 / 7668213
pancreatic tumor8 / 10461676
primitive neuroectodermal tumor of the CNS22 / 125680175
prostate cancer3 / 10268029
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor9 / 9025799
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue6 / 13106457
adrenal gland57 / 331971717
ascites1 / 4001524
bladder12 / 29757403
blood49 / 123478396
bone9 / 71655125
bone marrow2 / 4880140
brain840 / 1100989762
cervix7 / 48171145
connective tissue49 / 149255328
ear8 / 16212493
embryonic tissue4 / 21572218
esophagus55 / 202092721
eye17 / 21105480
heart142 / 896261584
intestine214 / 234472912
kidney182 / 211777859
larynx0 / 241450 
liver48 / 207743231
lung478 / 3369741418
lymph0 / 442700 
lymph node0 / 916100 
mammary gland81 / 153271528
mouth94 / 670521401
muscle23 / 107715213
nerve17 / 157681078
ovary0 / 1020510 
pancreas60 / 214812279
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta25 / 28082589
prostate172 / 189345908
salivary gland0 / 201550 
skin19 / 21057490
spleen376 / 539526969
stomach50 / 96619517
testis54 / 330442163
thymus147 / 811311811
thyroid13 / 47473273
tonsil0 / 169990 
trachea122 / 524132327
umbilical cord0 / 136800 
uterus161 / 232878691
vascular49 / 51780946
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 200799_at
Cell line Expression level Expression bar
721_B_lymphoblasts74.85
Adipocyte161.45
AdrenalCortex404.9
Adrenalgland1304.75
Amygdala1354.15
Appendix636.3
AtrioventricularNode3329.05
BDCA4+_DentriticCells264.6
Bonemarrow1770.65
BronchialEpithelialCells361.05
CD105+_Endothelial861.2
CD14+_Monocytes1096.1
CD19+_BCells(neg._sel.)39.45
CD33+_Myeloid2143.25
CD34+1000.8
CD4+_Tcells97.9
CD56+_NKCells455.05
CD71+_EarlyErythroid37.3
CD8+_Tcells36.2
CardiacMyocytes53.6
Caudatenucleus733.6
Cerebellum877.7
CerebellumPeduncles351.2
CiliaryGanglion1215.15
CingulateCortex278.85
Colorectaladenocarcinoma777.2
DorsalRootGanglion289.15
FetalThyroid218.35
Fetalbrain1746.35
Fetalliver267.7
Fetallung1536.05
GlobusPallidus168.75
Heart1578.55
Hypothalamus1587.45
Kidney989.25
Leukemia_chronicMyelogenousK-5621515.1
Leukemia_promyelocytic-HL-602.8
Leukemialymphoblastic(MOLT-4)2.45
Liver4409.25
Lung2971.85
Lymphnode1791.75
Lymphoma_burkitts(Daudi)4.05
Lymphoma_burkitts(Raji)4.55
MedullaOblongata453.65
OccipitalLobe512.4
OlfactoryBulb3845
Ovary7.85
Pancreas1973.25
PancreaticIslet1075
ParietalLobe442.85
Pituitary1348.5
Placenta498.05
Pons251.3
PrefrontalCortex781.1
Prostate5057.8
Salivarygland232
SkeletalMuscle1935.45
Skin157.95
SmoothMuscle183.65
Spinalcord3184.05
SubthalamicNucleus136.25
SuperiorCervicalGanglion374.7
TemporalLobe327.6
Testis617.15
TestisGermCell445.4
TestisIntersitial110
TestisLeydigCell364.15
TestisSeminiferousTubule237.1
Thalamus535.45
Thymus1625.9
Thyroid2191.95
Tongue337.9
Tonsil238.9
Trachea2097.15
TrigeminalGanglion881.3
Uterus2675.75
UterusCorpus61.7
WholeBlood1851.7
Wholebrain1676.45
colon1060.9
pineal_day1079.32
pineal_night772.62
retina1721.3
small_intestine621.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P111132
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala10.76 ± 0.23
Basal Forebrain10.96 ± 0.16
Basal Part of Pons11.69 ± 0.47
Cerebellar Cortex10.91 ± 0.14
Cerebellar Nuclei12.56 ± 0.35
Claustrum10.9 ± 0.37
Epithalamus12.33 ± 0.52
Frontal Lobe11.33 ± 0.43
Globus Pallidus12.51 ± 0.2
Hypothalamus11.17 ± 0.83
Insula11.42 ± 0.28
Limbic Lobe11.13 ± 0.42
Mesencephalon11.28 ± 0.49
Myelencephalon11.27 ± 0.48
Occipital Lobe11.05 ± 0.39
Parietal Lobe11.07 ± 0.38
Pontine Tegmentum11.2 ± 0.43
Striatum11.97 ± 0.42
Subthalamus11.83 ± 0.07
Temporal Lobe11.14 ± 0.34
Thalamus11.42 ± 0.28
White Matter13.35 ± 0.63
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Hspa1aCBCerebellum0
0
Hspa1aCTXCerebral cortex0
0
Hspa1aHIPHippocampal region0
0
Hspa1aHPFHippocampal formation0
0
Hspa1aHYHypothalamus0
0
Hspa1aLSXLateral septal complex0
0
Hspa1aMBMidbrain0
0
Hspa1aMYMedulla0
0
Hspa1aOLFOlfactory bulb0
0
Hspa1aPPons0
0
Hspa1aPALPallidum0
0
Hspa1aRHPRetrohippocampal region0
0
Hspa1asAMYStriatum-like amygdalar nuclei0
0
Hspa1aSTRStriatum0
0
Hspa1aSTRdStriatum dorsal region0
0
Hspa1aSTRvStriatum ventral region0
0
Hspa1aTHThalamus0
0
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
HSP71_HUMAN_0 0 0 0 IINEPTAAAIAYGLDR PRIDE
HSP71_HUMAN_0 0 0 0 TTPSYVAFTDTER PRIDE
HSP71_HUMAN_112 14 112 125 AFYPEEISSMVLTK PRIDE
HSP71_HUMAN_113 14 113 126 AFYPEEISSMVLTK PRIDE
HSP71_HUMAN_155 16 155 170 QATKDAGVIAGLNVLR PRIDE
HSP71_HUMAN_156 16 156 171 QATKDAGVIAGLNVLR PRIDE
HSP71_HUMAN_159 12 159 170 DAGVIAGLNVLR PRIDE
HSP71_HUMAN_160 12 160 171 DAGVIAGLNVLR PRIDE
HSP71_HUMAN_171 16 171 186 IINEPTAAAIAYGLDR PRIDE
HSP71_HUMAN_172 16 172 187 IINEPTAAAIAYGLDR PRIDE
HSP71_HUMAN_22 15 22 36 QHGKVEIIANDQGNR PRIDE
HSP71_HUMAN_220 16 220 235 ATAGDTHLGGEDFDNR PRIDE
HSP71_HUMAN_236 10 236 245 LVNHFVEEFK PRIDE
HSP71_HUMAN_236 11 236 246 LVNHFVEEFKR PRIDE
HSP71_HUMAN_248 11 248 258 KHKKDISQNKR PRIDE
HSP71_HUMAN_25 11 25 35 VEIIANDQGNR PRIDE
HSP71_HUMAN_26 11 26 36 VEIIANDQGNR PRIDE
HSP71_HUMAN_299 12 299 310 ARFEELCSDLFR PRIDE
HSP71_HUMAN_3 22 3 24 AAAIGIDLGTTYSCVGVFQHGK PRIDE
HSP71_HUMAN_3 33 3 35 AAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNR PRIDE
HSP71_HUMAN_301 10 301 310 FEELCSDLFR PRIDE
HSP71_HUMAN_312 11 312 322 STLEPVEKALR PRIDE
HSP71_HUMAN_316 7 316 322 PVEKALR PRIDE
HSP71_HUMAN_322 20 322 341 DAKLDKAQIHDLVLVGGSTR PRIDE
HSP71_HUMAN_325 17 325 341 LDKAQIHDLVLVGGSTR PRIDE
HSP71_HUMAN_328 14 328 341 AQIHDLVLVGGSTR PRIDE
HSP71_HUMAN_329 14 329 342 AQIHDLVLVGGSTR PRIDE
HSP71_HUMAN_348 9 348 356 LLQDFFNGR PRIDE
HSP71_HUMAN_349 9 349 357 LLQDFFNGR PRIDE
HSP71_HUMAN_36 13 36 48 TTPSYVAFTDTER PRIDE
HSP71_HUMAN_37 13 37 49 TTPSYVAFTDTER PRIDE
HSP71_HUMAN_384 32 384 415 SENVQDLLLLDVAPLSLGLETAGGVMTALIKR PRIDE
HSP71_HUMAN_423 24 423 446 QTQIFTTYSDNQPGVLIQVYEGER PRIDE
HSP71_HUMAN_424 24 424 447 QTQIFTTYSDNQPGVLIQVYEGER PRIDE
HSP71_HUMAN_470 24 470 493 GVPQIEVTFDIDANGILNVTATDK PRIDE
HSP71_HUMAN_49 23 49 71 LIGDAAKNQVALNPQNTVFDAKR PRIDE
HSP71_HUMAN_517 16 517 532 MVQEAEKYKAEDEVQR PRIDE
HSP71_HUMAN_539 11 539 549 NALESYAFNMK PRIDE
HSP71_HUMAN_540 11 540 550 NALESYAFNMK PRIDE
HSP71_HUMAN_56 15 56 70 NQVALNPQNTVFDAK PRIDE
HSP71_HUMAN_56 16 56 71 NQVALNPQNTVFDAKR PRIDE
HSP71_HUMAN_569 26 569 594 VLDKCQEVISWLDANTLAEKDEFEHK PRIDE
HSP71_HUMAN_57 15 57 71 NQVALNPQNTVFDAK PRIDE
HSP71_HUMAN_573 22 573 594 CQEVISWLDANTLAEKDEFEHK PRIDE
HSP71_HUMAN_597 32 597 628 KELEQVCNPIISGLYQGAGGPGPGGFGAQGPK PRIDE
HSP71_HUMAN_598 31 598 628 ELEQVCNPIISGLYQGAGGPGPGGFGAQGPK PRIDE
HSP71_HUMAN_63 10 63 72 PQNTVFDAKR PRIDE
HSP71_HUMAN_77 11 77 87 FGDPVVQSDMK PRIDE
HSP71_HUMAN_77 25 77 101 FGDPVVQSDMKHWPFQVINDGDKPK PRIDE
HSP71_HUMAN_88 14 88 101 HWPFQVINDGDKPK PRIDE
PAp00000128 22 4 25 AAAIGIDLGTTYSCVGVFQHGK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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