AutismKB 2.0

Annotation Detail for HSPA1B


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Basic Information Top
Gene Symbol:HSPA1B ( FLJ54328,HSP70-1B,HSP70-2,HSPA1A )
Gene Full Name: heat shock 70kDa protein 1B
Band: 6p21.33
Quick LinksEntrez ID:3304; OMIM: 603012; Uniprot ID:HSP71_HUMAN; ENSEMBL ID: ENSG00000204388; HGNC ID: 5233
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst2 / 6231932
fetus89 / 564012157
neonate4 / 31097128
infant1 / 2362042
juvenile12 / 55556215
adult207 / 1939121106
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma22 / 174751258
breast (mammary gland) tumor11 / 94178116
cervical tumor3 / 3436687
chondrosarcoma1 / 8282312
colorectal tumor14 / 114246122
esophageal tumor34 / 172901966
gastrointestinal tumor15 / 119369125
germ cell tumor19 / 26384572
glioma8 / 10688374
head and neck tumor9 / 13630266
kidney tumor14 / 68959203
leukemia5 / 9584252
liver tumor9 / 9635993
lung tumor23 / 103127223
lymphoma0 / 717550 
non-neoplasia19 / 97250195
normal601 / 3360307178
ovarian tumor8 / 76682104
pancreatic tumor6 / 10461657
primitive neuroectodermal tumor of the CNS18 / 125680143
prostate cancer4 / 10268038
retinoblastoma0 / 463560 
skin tumor7 / 12494956
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor8 / 9025788
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue8 / 13106610
adrenal gland13 / 33197391
ascites2 / 4001549
bladder35 / 297571176
blood10 / 12347880
bone0 / 716550 
bone marrow4 / 4880181
brain247 / 1100989224
cervix5 / 48171103
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue8 / 21572237
esophagus35 / 202091731
eye12 / 21105456
heart32 / 89626357
intestine39 / 234472166
kidney48 / 211777226
larynx2 / 2414582
liver15 / 20774372
lung55 / 336974163
lymph0 / 442700 
lymph node1 / 9161010
mammary gland16 / 153271104
mouth9 / 67052134
muscle6 / 10771555
nerve4 / 15768253
ovary9 / 10205188
pancreas34 / 214812158
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta5 / 28082517
prostate37 / 189345195
salivary gland0 / 201550 
skin13 / 21057461
spleen77 / 539521427
stomach16 / 96619165
testis14 / 33044242
thymus33 / 81131406
thyroid15 / 47473315
tonsil0 / 169990 
trachea42 / 52413801
umbilical cord0 / 136800 
uterus64 / 232878274
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 200799_at
Cell line Expression level Expression bar
721_B_lymphoblasts74.85
Adipocyte161.45
AdrenalCortex404.9
Adrenalgland1304.75
Amygdala1354.15
Appendix636.3
AtrioventricularNode3329.05
BDCA4+_DentriticCells264.6
Bonemarrow1770.65
BronchialEpithelialCells361.05
CD105+_Endothelial861.2
CD14+_Monocytes1096.1
CD19+_BCells(neg._sel.)39.45
CD33+_Myeloid2143.25
CD34+1000.8
CD4+_Tcells97.9
CD56+_NKCells455.05
CD71+_EarlyErythroid37.3
CD8+_Tcells36.2
CardiacMyocytes53.6
Caudatenucleus733.6
Cerebellum877.7
CerebellumPeduncles351.2
CiliaryGanglion1215.15
CingulateCortex278.85
Colorectaladenocarcinoma777.2
DorsalRootGanglion289.15
FetalThyroid218.35
Fetalbrain1746.35
Fetalliver267.7
Fetallung1536.05
GlobusPallidus168.75
Heart1578.55
Hypothalamus1587.45
Kidney989.25
Leukemia_chronicMyelogenousK-5621515.1
Leukemia_promyelocytic-HL-602.8
Leukemialymphoblastic(MOLT-4)2.45
Liver4409.25
Lung2971.85
Lymphnode1791.75
Lymphoma_burkitts(Daudi)4.05
Lymphoma_burkitts(Raji)4.55
MedullaOblongata453.65
OccipitalLobe512.4
OlfactoryBulb3845
Ovary7.85
Pancreas1973.25
PancreaticIslet1075
ParietalLobe442.85
Pituitary1348.5
Placenta498.05
Pons251.3
PrefrontalCortex781.1
Prostate5057.8
Salivarygland232
SkeletalMuscle1935.45
Skin157.95
SmoothMuscle183.65
Spinalcord3184.05
SubthalamicNucleus136.25
SuperiorCervicalGanglion374.7
TemporalLobe327.6
Testis617.15
TestisGermCell445.4
TestisIntersitial110
TestisLeydigCell364.15
TestisSeminiferousTubule237.1
Thalamus535.45
Thymus1625.9
Thyroid2191.95
Tongue337.9
Tonsil238.9
Trachea2097.15
TrigeminalGanglion881.3
Uterus2675.75
UterusCorpus61.7
WholeBlood1851.7
Wholebrain1676.45
colon1060.9
pineal_day1079.32
pineal_night772.62
retina1721.3
small_intestine621.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P682285
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.97 ± 0.6
Basal Forebrain6.68 ± 0.41
Basal Part of Pons7.46 ± 0.58
Cerebellar Cortex6.5 ± 0.27
Cerebellar Nuclei7.74 ± 0.33
Claustrum6.72 ± 0.47
Epithalamus8.04 ± 0.65
Frontal Lobe6.8 ± 0.63
Globus Pallidus8.43 ± 0.46
Hypothalamus6.86 ± 0.71
Insula6.73 ± 0.38
Limbic Lobe6.75 ± 0.61
Mesencephalon6.78 ± 0.52
Myelencephalon6.88 ± 0.67
Occipital Lobe6.71 ± 0.48
Parietal Lobe6.7 ± 0.45
Pontine Tegmentum6.69 ± 0.45
Striatum7.45 ± 0.55
Subthalamus7.01 ± 0.81
Temporal Lobe6.71 ± 0.45
Thalamus7.06 ± 0.55
White Matter9.24 ± 0.59
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
HSP71_HUMAN_0 0 0 0 IINEPTAAAIAYGLDR PRIDE
HSP71_HUMAN_0 0 0 0 TTPSYVAFTDTER PRIDE
HSP71_HUMAN_112 14 112 125 AFYPEEISSMVLTK PRIDE
HSP71_HUMAN_113 14 113 126 AFYPEEISSMVLTK PRIDE
HSP71_HUMAN_155 16 155 170 QATKDAGVIAGLNVLR PRIDE
HSP71_HUMAN_156 16 156 171 QATKDAGVIAGLNVLR PRIDE
HSP71_HUMAN_159 12 159 170 DAGVIAGLNVLR PRIDE
HSP71_HUMAN_160 12 160 171 DAGVIAGLNVLR PRIDE
HSP71_HUMAN_171 16 171 186 IINEPTAAAIAYGLDR PRIDE
HSP71_HUMAN_172 16 172 187 IINEPTAAAIAYGLDR PRIDE
HSP71_HUMAN_22 15 22 36 QHGKVEIIANDQGNR PRIDE
HSP71_HUMAN_220 16 220 235 ATAGDTHLGGEDFDNR PRIDE
HSP71_HUMAN_236 10 236 245 LVNHFVEEFK PRIDE
HSP71_HUMAN_236 11 236 246 LVNHFVEEFKR PRIDE
HSP71_HUMAN_248 11 248 258 KHKKDISQNKR PRIDE
HSP71_HUMAN_25 11 25 35 VEIIANDQGNR PRIDE
HSP71_HUMAN_26 11 26 36 VEIIANDQGNR PRIDE
HSP71_HUMAN_299 12 299 310 ARFEELCSDLFR PRIDE
HSP71_HUMAN_3 22 3 24 AAAIGIDLGTTYSCVGVFQHGK PRIDE
HSP71_HUMAN_3 33 3 35 AAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNR PRIDE
HSP71_HUMAN_301 10 301 310 FEELCSDLFR PRIDE
HSP71_HUMAN_312 11 312 322 STLEPVEKALR PRIDE
HSP71_HUMAN_316 7 316 322 PVEKALR PRIDE
HSP71_HUMAN_322 20 322 341 DAKLDKAQIHDLVLVGGSTR PRIDE
HSP71_HUMAN_325 17 325 341 LDKAQIHDLVLVGGSTR PRIDE
HSP71_HUMAN_328 14 328 341 AQIHDLVLVGGSTR PRIDE
HSP71_HUMAN_329 14 329 342 AQIHDLVLVGGSTR PRIDE
HSP71_HUMAN_348 9 348 356 LLQDFFNGR PRIDE
HSP71_HUMAN_349 9 349 357 LLQDFFNGR PRIDE
HSP71_HUMAN_36 13 36 48 TTPSYVAFTDTER PRIDE
HSP71_HUMAN_37 13 37 49 TTPSYVAFTDTER PRIDE
HSP71_HUMAN_384 32 384 415 SENVQDLLLLDVAPLSLGLETAGGVMTALIKR PRIDE
HSP71_HUMAN_423 24 423 446 QTQIFTTYSDNQPGVLIQVYEGER PRIDE
HSP71_HUMAN_424 24 424 447 QTQIFTTYSDNQPGVLIQVYEGER PRIDE
HSP71_HUMAN_470 24 470 493 GVPQIEVTFDIDANGILNVTATDK PRIDE
HSP71_HUMAN_49 23 49 71 LIGDAAKNQVALNPQNTVFDAKR PRIDE
HSP71_HUMAN_517 16 517 532 MVQEAEKYKAEDEVQR PRIDE
HSP71_HUMAN_539 11 539 549 NALESYAFNMK PRIDE
HSP71_HUMAN_540 11 540 550 NALESYAFNMK PRIDE
HSP71_HUMAN_56 15 56 70 NQVALNPQNTVFDAK PRIDE
HSP71_HUMAN_56 16 56 71 NQVALNPQNTVFDAKR PRIDE
HSP71_HUMAN_569 26 569 594 VLDKCQEVISWLDANTLAEKDEFEHK PRIDE
HSP71_HUMAN_57 15 57 71 NQVALNPQNTVFDAK PRIDE
HSP71_HUMAN_573 22 573 594 CQEVISWLDANTLAEKDEFEHK PRIDE
HSP71_HUMAN_597 32 597 628 KELEQVCNPIISGLYQGAGGPGPGGFGAQGPK PRIDE
HSP71_HUMAN_598 31 598 628 ELEQVCNPIISGLYQGAGGPGPGGFGAQGPK PRIDE
HSP71_HUMAN_63 10 63 72 PQNTVFDAKR PRIDE
HSP71_HUMAN_77 11 77 87 FGDPVVQSDMK PRIDE
HSP71_HUMAN_77 25 77 101 FGDPVVQSDMKHWPFQVINDGDKPK PRIDE
HSP71_HUMAN_88 14 88 101 HWPFQVINDGDKPK PRIDE
PAp00000128 22 4 25 AAAIGIDLGTTYSCVGVFQHGK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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