AutismKB 2.0

Annotation Detail for HSPA1L


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Basic Information Top
Gene Symbol:HSPA1L ( HSP70-1L,HSP70-HOM,HSP70T,hum70t )
Gene Full Name: heat shock 70kDa protein 1-like
Band: 6p21.33
Quick LinksEntrez ID:3305; OMIM: 140559; Uniprot ID:HS71L_HUMAN; ENSEMBL ID: ENSG00000204390; HGNC ID: 5234
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus9 / 56401215
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult5 / 19391212
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor2 / 2638457
glioma3 / 10688328
head and neck tumor2 / 13630214
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal62 / 336030718
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain10 / 11009899
cervix0 / 481710 
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye3 / 21105414
heart1 / 8962611
intestine1 / 2344724
kidney2 / 2117779
larynx0 / 241450 
liver3 / 20774314
lung3 / 3369748
lymph0 / 442700 
lymph node0 / 916100 
mammary gland5 / 15327132
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta0 / 2808250 
prostate1 / 1893455
salivary gland0 / 201550 
skin0 / 2105740 
spleen1 / 5395218
stomach0 / 966190 
testis37 / 330442111
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210189_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.05
Adipocyte6.3
AdrenalCortex7.3
Adrenalgland6.45
Amygdala6.8
Appendix6.8
AtrioventricularNode5.05
BDCA4+_DentriticCells6.25
Bonemarrow8.45
BronchialEpithelialCells6
CD105+_Endothelial6.2
CD14+_Monocytes7.2
CD19+_BCells(neg._sel.)6.5
CD33+_Myeloid8.7
CD34+7.5
CD4+_Tcells7.7
CD56+_NKCells8.2
CD71+_EarlyErythroid6
CD8+_Tcells5.9
CardiacMyocytes8.05
Caudatenucleus9.7
Cerebellum5.75
CerebellumPeduncles7.6
CiliaryGanglion4.6
CingulateCortex8.7
Colorectaladenocarcinoma6.7
DorsalRootGanglion5.05
FetalThyroid6.3
Fetalbrain6.75
Fetalliver5.6
Fetallung5.65
GlobusPallidus4.95
Heart9.95
Hypothalamus7.5
Kidney5.35
Leukemia_chronicMyelogenousK-5625.85
Leukemia_promyelocytic-HL-606.4
Leukemialymphoblastic(MOLT-4)5.15
Liver9.75
Lung7.7
Lymphnode7.15
Lymphoma_burkitts(Daudi)8.55
Lymphoma_burkitts(Raji)9.3
MedullaOblongata6.25
OccipitalLobe6.1
OlfactoryBulb5.35
Ovary4.45
Pancreas5.35
PancreaticIslet6.95
ParietalLobe7.05
Pituitary7.9
Placenta6.8
Pons6.4
PrefrontalCortex9.55
Prostate7.4
Salivarygland5.3
SkeletalMuscle10.6
Skin4.9
SmoothMuscle7.25
Spinalcord8.4
SubthalamicNucleus5.95
SuperiorCervicalGanglion8
TemporalLobe6.1
Testis253.95
TestisGermCell283.35
TestisIntersitial333.3
TestisLeydigCell118.7
TestisSeminiferousTubule166.1
Thalamus6.8
Thymus6.65
Thyroid8.75
Tongue6.5
Tonsil6.3
Trachea5.6
TrigeminalGanglion7
Uterus5.6
UterusCorpus6.2
WholeBlood8
Wholebrain6.55
colon6.35
pineal_day8.1
pineal_night7.8
retina7.775
small_intestine5.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15889_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.06 ± 0.95
Basal Forebrain3.81 ± 0.37
Basal Part of Pons3.78 ± 0.62
Cerebellar Cortex3.46 ± 0.58
Cerebellar Nuclei3.96 ± 0.79
Claustrum4.69 ± 0.95
Epithalamus3.39 ± 0.72
Frontal Lobe3.79 ± 0.66
Globus Pallidus4.38 ± 0.48
Hypothalamus3.81 ± 0.76
Insula3.51 ± 0.39
Limbic Lobe3.92 ± 0.67
Mesencephalon3.93 ± 0.74
Myelencephalon3.88 ± 0.72
Occipital Lobe3.75 ± 0.81
Parietal Lobe3.93 ± 0.77
Pontine Tegmentum3.9 ± 0.67
Striatum4.13 ± 0.61
Subthalamus3.65 ± 0.37
Temporal Lobe3.64 ± 0.68
Thalamus3.9 ± 0.6
White Matter4.81 ± 0.58
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Hspa1lCBCerebellum0.86
1.16
Hspa1lCTXCerebral cortex26
14.94
Hspa1lHIPHippocampal region10.32
11.04
Hspa1lHPFHippocampal formation19.87
16.16
Hspa1lHYHypothalamus4.32
1.87
Hspa1lLSXLateral septal complex2.84
1.56
Hspa1lMBMidbrain1.65
1.82
Hspa1lMYMedulla0.65
0.57
Hspa1lOLFOlfactory bulb30.67
20.17
Hspa1lPPons0.71
0.75
Hspa1lPALPallidum1.63
0.81
Hspa1lRHPRetrohippocampal region33.14
21.89
Hspa1lsAMYStriatum-like amygdalar nuclei16.77
8.06
Hspa1lSTRStriatum3.86
2.15
Hspa1lSTRdStriatum dorsal region2.08
1.41
Hspa1lSTRvStriatum ventral region2.08
0.98
Hspa1lTHThalamus1.53
1.21
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
HS71L_HUMAN_114 14 114 127 AFYPEEISSMVLTK PRIDE
HS71L_HUMAN_141 17 141 157 VTNAVITVPAYFNDSQR PRIDE
HS71L_HUMAN_161 12 161 172 DAGVIAGLNVLR PRIDE
HS71L_HUMAN_162 12 162 173 DAGVIAGLNVLR PRIDE
HS71L_HUMAN_173 16 173 188 IINEPTAAAIAYGLDK PRIDE
HS71L_HUMAN_174 16 174 189 IINEPTAAAIAYGLDK PRIDE
HS71L_HUMAN_222 16 222 237 ATAGDTHLGGEDFDNR PRIDE
HS71L_HUMAN_27 11 27 37 VEIIANDQGNR PRIDE
HS71L_HUMAN_28 11 28 38 VEIIANDQGNR PRIDE
HS71L_HUMAN_315 10 315 324 TLEPVEKALR PRIDE
HS71L_HUMAN_330 14 330 343 AKIHDIVLVGGSTR PRIDE
HS71L_HUMAN_38 13 38 50 TTPSYVAFTDTER PRIDE
HS71L_HUMAN_38 14 38 51 RTTPSYVAFTDTER PRIDE
HS71L_HUMAN_39 13 39 51 TTPSYVAFTDTER PRIDE
HS71L_HUMAN_40 12 40 51 TPSYVAFTDTER PRIDE
HS71L_HUMAN_425 24 425 448 QTQIFTTYSDNQPGVLIQVYEGER PRIDE
HS71L_HUMAN_51 23 51 73 LIGDAAKNQVAMNPQNTVFDAKR PRIDE
HS71L_HUMAN_541 11 541 551 NALESYAFNMK PRIDE
HS71L_HUMAN_60 15 60 74 QVAMNPQNTVFDAKR PRIDE
PAp00007014 10 18 27 SCVGVFQHGK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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