AutismKB 2.0

Annotation Detail for HSPA6


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Basic Information Top
Gene Symbol:HSPA6 ( - )
Gene Full Name: heat shock 70kDa protein 6 (HSP70B')
Band: 1q23.3
Quick LinksEntrez ID:3310; OMIM: 140555; Uniprot ID:HSP76_HUMAN; ENSEMBL ID: ENSG00000173110; HGNC ID: 5239
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus4 / 5640127
neonate2 / 3109764
infant0 / 236200 
juvenile0 / 555560 
adult36 / 193912118
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma3 / 17475171
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor2 / 17290115
gastrointestinal tumor2 / 11936916
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor2 / 6895929
leukemia3 / 9584231
liver tumor0 / 963590 
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia4 / 9725041
normal63 / 336030718
ovarian tumor1 / 7668213
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor4 / 12494932
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland3 / 3319790
ascites0 / 400150 
bladder3 / 29757100
blood14 / 123478113
bone1 / 7165513
bone marrow1 / 4880120
brain11 / 11009899
cervix0 / 481710 
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus2 / 2020998
eye3 / 21105414
heart3 / 8962633
intestine4 / 23447217
kidney2 / 2117779
larynx0 / 241450 
liver0 / 2077430 
lung26 / 33697477
lymph0 / 442700 
lymph node0 / 916100 
mammary gland2 / 15327113
mouth0 / 670520 
muscle1 / 1077159
nerve0 / 157680 
ovary2 / 10205119
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta0 / 2808250 
prostate2 / 18934510
salivary gland0 / 201550 
skin5 / 21057423
spleen4 / 5395274
stomach3 / 9661931
testis0 / 3304420 
thymus13 / 81131160
thyroid0 / 474730 
tonsil0 / 169990 
trachea10 / 52413190
umbilical cord0 / 136800 
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 117_at
Cell line Expression level Expression bar
721_B_lymphoblasts12.55
Adipocyte10.6
AdrenalCortex14
Adrenalgland9.85
Amygdala10.15
Appendix11.55
AtrioventricularNode33.6
BDCA4+_DentriticCells36.15
Bonemarrow16.65
BronchialEpithelialCells9.4
CD105+_Endothelial9.5
CD14+_Monocytes77.15
CD19+_BCells(neg._sel.)10.65
CD33+_Myeloid18.75
CD34+11.8
CD4+_Tcells9.65
CD56+_NKCells44.45
CD71+_EarlyErythroid9.9
CD8+_Tcells8.7
CardiacMyocytes15.4
Caudatenucleus9.6
Cerebellum9
CerebellumPeduncles13.5
CiliaryGanglion13.7
CingulateCortex11.4
Colorectaladenocarcinoma9.9
DorsalRootGanglion12
FetalThyroid14.95
Fetalbrain10.4
Fetalliver12.3
Fetallung25.05
GlobusPallidus15.4
Heart14.9
Hypothalamus11.15
Kidney10.85
Leukemia_chronicMyelogenousK-56213.1
Leukemia_promyelocytic-HL-6010.1
Leukemialymphoblastic(MOLT-4)8.55
Liver18.65
Lung15.7
Lymphnode23.2
Lymphoma_burkitts(Daudi)16.3
Lymphoma_burkitts(Raji)17.8
MedullaOblongata9.05
OccipitalLobe10.35
OlfactoryBulb26.9
Ovary8.75
Pancreas16.4
PancreaticIslet17.75
ParietalLobe12.5
Pituitary62.95
Placenta11.85
Pons10.7
PrefrontalCortex11.65
Prostate12.3
Salivarygland8.4
SkeletalMuscle22.75
Skin11.9
SmoothMuscle11.5
Spinalcord16.05
SubthalamicNucleus10.75
SuperiorCervicalGanglion17.3
TemporalLobe9.55
Testis9.25
TestisGermCell8.7
TestisIntersitial9.45
TestisLeydigCell11.75
TestisSeminiferousTubule9.3
Thalamus10.55
Thymus13.35
Thyroid12.6
Tongue14.2
Tonsil11.35
Trachea15.9
TrigeminalGanglion17.8
Uterus7.95
UterusCorpus19.1
WholeBlood334.8
Wholebrain7.8
colon9.45
pineal_day38.14
pineal_night12.12
retina12.975
small_intestine9.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_13369_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.05 ± 1.04
Basal Forebrain1.41 ± 0.22
Basal Part of Pons1.26 ± 0.6
Cerebellar Cortex1.3 ± 0.47
Cerebellar Nuclei1.94 ± 0.76
Claustrum2.61 ± 1.07
Epithalamus1.41 ± 0.83
Frontal Lobe1.38 ± 0.65
Globus Pallidus2.09 ± 0.62
Hypothalamus1.55 ± 0.74
Insula1.39 ± 0.62
Limbic Lobe1.5 ± 0.73
Mesencephalon1.64 ± 0.73
Myelencephalon1.59 ± 0.7
Occipital Lobe1.7 ± 0.89
Parietal Lobe1.53 ± 0.79
Pontine Tegmentum1.53 ± 0.72
Striatum1.67 ± 0.77
Subthalamus1.58 ± 0.63
Temporal Lobe1.42 ± 0.73
Thalamus1.53 ± 0.57
White Matter3.04 ± 1.11
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
HSP76_HUMAN_0 0 0 0 IINEPTAAAIAYGLDR PRIDE
HSP76_HUMAN_0 0 0 0 TTPSYVAFTDTER PRIDE
HSP76_HUMAN_173 16 173 188 IINEPTAAAIAYGLDR PRIDE
HSP76_HUMAN_174 16 174 189 IINEPTAAAIAYGLDR PRIDE
HSP76_HUMAN_27 11 27 37 VEILANDQGNR PRIDE
HSP76_HUMAN_28 11 28 38 VEILANDQGNR PRIDE
HSP76_HUMAN_38 13 38 50 TTPSYVAFTDTER PRIDE
HSP76_HUMAN_39 13 39 51 TTPSYVAFTDTER PRIDE
HSP76_HUMAN_496 16 496 511 STGKANKITITNDKGR PRIDE
HSP76_HUMAN_6 22 6 27 ELAVGIDLGTTYSCVGVFQQGR PRIDE
PAp00000674 12 302 313 ARFEELCSDLFR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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