AutismKB 2.0

Annotation Detail for HSPB1


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Basic Information Top
Gene Symbol:HSPB1 ( CMT2F,DKFZp586P1322,HMN2B,HS.76067,HSP27,HSP28,Hsp25,SRP27 )
Gene Full Name: heat shock 27kDa protein 1
Band: 7q11.23
Quick LinksEntrez ID:3315; OMIM: 602195; Uniprot ID:HSPB1_HUMAN; ENSEMBL ID: ENSG00000106211; HGNC ID: 5246
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body19 / 70761268
blastocyst35 / 62319561
fetus131 / 564012232
neonate2 / 3109764
infant1 / 2362042
juvenile8 / 55556143
adult1001 / 1939121516
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor5 / 12794390
bladder carcinoma25 / 174751430
breast (mammary gland) tumor64 / 94178679
cervical tumor8 / 34366232
chondrosarcoma28 / 82823338
colorectal tumor15 / 114246131
esophageal tumor15 / 17290867
gastrointestinal tumor124 / 1193691038
germ cell tumor47 / 263845178
glioma122 / 1068831141
head and neck tumor49 / 136302359
kidney tumor47 / 68959681
leukemia6 / 9584262
liver tumor53 / 96359550
lung tumor89 / 103127863
lymphoma3 / 7175541
non-neoplasia33 / 97250339
normal1045 / 3360307310
ovarian tumor91 / 766821186
pancreatic tumor128 / 1046161223
primitive neuroectodermal tumor of the CNS19 / 125680151
prostate cancer33 / 102680321
retinoblastoma12 / 46356258
skin tumor95 / 124949760
soft tissue/muscle tissue tumor44 / 125191351
uterine tumor33 / 90257365
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland11 / 33197331
ascites65 / 400151624
bladder22 / 29757739
blood7 / 12347856
bone21 / 71655293
bone marrow5 / 48801102
brain225 / 1100989204
cervix10 / 48171207
connective tissue25 / 149255167
ear0 / 162120 
embryonic tissue65 / 215722301
esophagus15 / 20209742
eye117 / 211054554
heart78 / 89626870
intestine117 / 234472498
kidney75 / 211777354
larynx8 / 24145331
liver65 / 207743312
lung167 / 336974495
lymph2 / 4427045
lymph node34 / 91610371
mammary gland78 / 153271508
mouth26 / 67052387
muscle137 / 1077151271
nerve9 / 15768570
ovary108 / 1020511058
pancreas185 / 214812861
parathyroid8 / 20539389
pharynx1 / 4132824
pituitary gland3 / 16585180
placenta122 / 280825434
prostate58 / 189345306
salivary gland11 / 20155545
skin165 / 210574783
spleen3 / 5395255
stomach38 / 96619393
testis22 / 33044266
thymus5 / 8113161
thyroid13 / 47473273
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord2 / 13680146
uterus153 / 232878656
vascular15 / 51780289
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201841_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts68.6
Adipocyte2274.25
AdrenalCortex147.7
Adrenalgland263.7
Amygdala181.45
Appendix309
AtrioventricularNode524.95
BDCA4+_DentriticCells23.65
Bonemarrow11.05
BronchialEpithelialCells1330.15
CD105+_Endothelial523.45
CD14+_Monocytes15.65
CD19+_BCells(neg._sel.)57.35
CD33+_Myeloid16.5
CD34+514.5
CD4+_Tcells50.25
CD56+_NKCells20.25
CD71+_EarlyErythroid110.4
CD8+_Tcells46.55
CardiacMyocytes1048.3
Caudatenucleus81.2
Cerebellum34.2
CerebellumPeduncles20.65
CiliaryGanglion203.25
CingulateCortex54.3
Colorectaladenocarcinoma1373.85
DorsalRootGanglion98
FetalThyroid1036.6
Fetalbrain46.2
Fetalliver107.45
Fetallung860.3
GlobusPallidus18.6
Heart5293.7
Hypothalamus209.25
Kidney251.4
Leukemia_chronicMyelogenousK-562613.2
Leukemia_promyelocytic-HL-606.45
Leukemialymphoblastic(MOLT-4)16.3
Liver884.35
Lung3335.35
Lymphnode429.65
Lymphoma_burkitts(Daudi)9.8
Lymphoma_burkitts(Raji)10.15
MedullaOblongata33.2
OccipitalLobe33.5
OlfactoryBulb1349.25
Ovary199.4
Pancreas542.4
PancreaticIslet882.3
ParietalLobe29.7
Pituitary140.25
Placenta3957.1
Pons18.85
PrefrontalCortex444.65
Prostate5217.9
Salivarygland132.6
SkeletalMuscle2308.4
Skin984.9
SmoothMuscle1083.25
Spinalcord307.4
SubthalamicNucleus49.15
SuperiorCervicalGanglion17.2
TemporalLobe61.85
Testis46.15
TestisGermCell237.3
TestisIntersitial114.8
TestisLeydigCell112.05
TestisSeminiferousTubule28
Thalamus204.75
Thymus648.7
Thyroid2991.1
Tongue2810.65
Tonsil1048.4
Trachea328.4
TrigeminalGanglion220
Uterus3414.05
UterusCorpus583.95
WholeBlood21.3
Wholebrain202.25
colon2010.45
pineal_day1144.48
pineal_night837.6
retina1245.15
small_intestine1099.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P86537
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala10.44 ± 0.11
Basal Forebrain10.74 ± 0.11
Basal Part of Pons10.95 ± 0.2
Cerebellar Cortex10.17 ± 0.19
Cerebellar Nuclei11.13 ± 0.25
Claustrum10.32 ± 0.31
Epithalamus11.03 ± 0.2
Frontal Lobe10.68 ± 0.39
Globus Pallidus11.57 ± 0.27
Hypothalamus11.04 ± 0.48
Insula10.68 ± 0.39
Limbic Lobe10.28 ± 0.51
Mesencephalon10.61 ± 0.4
Myelencephalon10.65 ± 0.39
Occipital Lobe10.11 ± 0.33
Parietal Lobe10.5 ± 0.41
Pontine Tegmentum10.6 ± 0.49
Striatum11.08 ± 0.35
Subthalamus10.5 ± 0.42
Temporal Lobe10.48 ± 0.37
Thalamus10.83 ± 0.3
White Matter10.8 ± 0.5
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Hspb1CBCerebellum2.95
3.98
Hspb1CTXCerebral cortex0.6
0.75
Hspb1HIPHippocampal region1.82
2.02
Hspb1HPFHippocampal formation1.49
1.6
Hspb1HYHypothalamus0.17
0.24
Hspb1LSXLateral septal complex0.03
0
Hspb1MBMidbrain0.17
0.3
Hspb1MYMedulla2.22
4.77
Hspb1OLFOlfactory bulb0.67
1.2
Hspb1PPons0.84
1.94
Hspb1PALPallidum0.37
0.69
Hspb1RHPRetrohippocampal region0.78
0.86
Hspb1sAMYStriatum-like amygdalar nuclei0.57
0.35
Hspb1STRStriatum0.35
0.32
Hspb1STRdStriatum dorsal region0.22
0.2
Hspb1STRvStriatum ventral region0.84
0.81
Hspb1THThalamus0.19
0.22
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
HSPB1_HUMAN_0 0 0 0 LFDQAFGLPR PRIDE
HSPB1_HUMAN_0 0 0 0 QLSSGVSEIR PRIDE
HSPB1_HUMAN_112 11 112 122 TKDGVVEITGK PRIDE
HSPB1_HUMAN_112 15 112 126 TKDGVVEITGKHEER PRIDE
HSPB1_HUMAN_113 11 113 123 TKDGVVEITGK PRIDE
HSPB1_HUMAN_114 13 114 126 DGVVEITGKHEER PRIDE
HSPB1_HUMAN_114 22 114 135 DGVVEITGKHEERQDEHGYISR PRIDE
HSPB1_HUMAN_12 15 12 26 GPSWDPFRDWYPHSR PRIDE
HSPB1_HUMAN_12 8 12 19 GPSWDPFR PRIDE
HSPB1_HUMAN_128 9 128 136 QDEHGYISR PRIDE
HSPB1_HUMAN_13 15 13 27 GPSWDPFRDWYPHSR PRIDE
HSPB1_HUMAN_13 8 13 20 GPSWDPFR PRIDE
HSPB1_HUMAN_140 31 140 170 KYTLPPGVDPTQVSSSLSPEGTLTVEAPMPK PRIDE
HSPB1_HUMAN_141 30 141 170 YTLPPGVDPTQVSSSLSPEGTLTVEAPMPK PRIDE
HSPB1_HUMAN_171 17 171 187 LATQSNEITIPVTFESR PRIDE
HSPB1_HUMAN_172 17 172 188 LATQSNEITIPVTFESR PRIDE
HSPB1_HUMAN_188 10 188 197 AQLGGPEAAK PRIDE
HSPB1_HUMAN_188 17 188 204 AQLGGPEAAKSDETAAK PRIDE
HSPB1_HUMAN_189 10 189 198 AQLGGPEAAK PRIDE
HSPB1_HUMAN_189 17 189 205 AQLGGPEAAKSDETAAK PRIDE
HSPB1_HUMAN_27 10 27 36 LFDQAFGLPR PRIDE
HSPB1_HUMAN_28 10 28 37 LFDQAFGLPR PRIDE
HSPB1_HUMAN_37 38 37 74 LPEEWSQWLGGSSWPGYVRPLPPAAIESPAVAAPAYSR PRIDE
HSPB1_HUMAN_38 38 38 75 LPEEWSQWLGGSSWPGYVRPLPPAAIESPAVAAPAYSR PRIDE
HSPB1_HUMAN_4 8 4 11 RVPFSLLR PRIDE
HSPB1_HUMAN_5 7 5 11 VPFSLLR PRIDE
HSPB1_HUMAN_5 8 5 12 RVPFSLLR PRIDE
HSPB1_HUMAN_57 19 57 75 PLPPAAIESPAVAAPAYSR PRIDE
HSPB1_HUMAN_79 10 79 88 QLSSGVSEIR PRIDE
HSPB1_HUMAN_80 10 80 89 QLSSGVSEIR PRIDE
HSPB1_HUMAN_94 18 94 111 WRVSLDVNHFAPDELTVK PRIDE
HSPB1_HUMAN_96 16 96 111 VSLDVNHFAPDELTVK PRIDE
HSPB1_HUMAN_96 18 96 113 VSLDVNHFAPDELTVKTK PRIDE
HSPB1_HUMAN_97 16 97 112 VSLDVNHFAPDELTVK PRIDE
PAp00035566 17 172 188 LATQSNEITIPVTFESR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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