AutismKB 2.0

Annotation Detail for HSPB2


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Basic Information Top
Gene Symbol:HSPB2 ( HSP27,Hs.78846,LOH11CR1K,MGC133245,MKBP )
Gene Full Name: heat shock 27kDa protein 2
Band: 11q23.1
Quick LinksEntrez ID:3316; OMIM: 602179; Uniprot ID:HSPB2_HUMAN; ENSEMBL ID: ENSG00000170276; HGNC ID: 5247
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus5 / 5640128
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult21 / 193912110
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal39 / 336030711
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone1 / 7165513
bone marrow0 / 488010 
brain9 / 11009898
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye2 / 2110549
heart7 / 8962678
intestine0 / 2344720 
kidney4 / 21177718
larynx0 / 241450 
liver0 / 2077430 
lung2 / 3369745
lymph0 / 442700 
lymph node0 / 916100 
mammary gland2 / 15327113
mouth0 / 670520 
muscle10 / 10771592
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin3 / 21057414
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205824_at
Cell line Expression level Expression bar
721_B_lymphoblasts9.2
Adipocyte88.3
AdrenalCortex17.95
Adrenalgland14.05
Amygdala9.3
Appendix21.5
AtrioventricularNode21.55
BDCA4+_DentriticCells8.9
Bonemarrow10.3
BronchialEpithelialCells8.85
CD105+_Endothelial8.15
CD14+_Monocytes9.7
CD19+_BCells(neg._sel.)6.75
CD33+_Myeloid9.4
CD34+9.2
CD4+_Tcells8.45
CD56+_NKCells8.4
CD71+_EarlyErythroid8.9
CD8+_Tcells6.4
CardiacMyocytes11.6
Caudatenucleus10.25
Cerebellum36.05
CerebellumPeduncles53.45
CiliaryGanglion9.2
CingulateCortex10.65
Colorectaladenocarcinoma8.55
DorsalRootGanglion14.3
FetalThyroid11.1
Fetalbrain9.65
Fetalliver8.05
Fetallung9.6
GlobusPallidus10.75
Heart507
Hypothalamus15.35
Kidney8.75
Leukemia_chronicMyelogenousK-5628.45
Leukemia_promyelocytic-HL-608.2
Leukemialymphoblastic(MOLT-4)7.9
Liver13.8
Lung13.9
Lymphnode10.3
Lymphoma_burkitts(Daudi)12.4
Lymphoma_burkitts(Raji)11.65
MedullaOblongata15.8
OccipitalLobe9
OlfactoryBulb24.55
Ovary14.65
Pancreas7.85
PancreaticIslet10.65
ParietalLobe11.55
Pituitary18.15
Placenta10.2
Pons10.25
PrefrontalCortex12.15
Prostate14.8
Salivarygland8.4
SkeletalMuscle34.4
Skin20.75
SmoothMuscle10.95
Spinalcord19.7
SubthalamicNucleus11.6
SuperiorCervicalGanglion12.35
TemporalLobe8.65
Testis10.65
TestisGermCell8.2
TestisIntersitial7.8
TestisLeydigCell17.15
TestisSeminiferousTubule8.6
Thalamus10.65
Thymus7.1
Thyroid12.15
Tongue33.55
Tonsil9.75
Trachea10.75
TrigeminalGanglion46.35
Uterus29.55
UterusCorpus28.2
WholeBlood9.3
Wholebrain18.85
colon9.15
pineal_day10.66
pineal_night10.8
retina18.425
small_intestine9.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_12142_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala12.06 ± 0.51
Basal Forebrain11.87 ± 0.35
Basal Part of Pons11.67 ± 0.42
Cerebellar Cortex11.18 ± 0.35
Cerebellar Nuclei11.75 ± 0.3
Claustrum12.53 ± 0.8
Epithalamus11.02 ± 0.64
Frontal Lobe11.63 ± 0.64
Globus Pallidus12.81 ± 0.36
Hypothalamus11.34 ± 0.54
Insula11.5 ± 0.52
Limbic Lobe11.97 ± 0.71
Mesencephalon11.75 ± 0.46
Myelencephalon11.83 ± 0.69
Occipital Lobe11.78 ± 0.62
Parietal Lobe11.74 ± 0.7
Pontine Tegmentum11.61 ± 0.65
Striatum11.86 ± 0.8
Subthalamus11.62 ± 0.2
Temporal Lobe11.66 ± 0.72
Thalamus11.73 ± 0.48
White Matter12.31 ± 0.43
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Hspb2CBCerebellum0
0
Hspb2CTXCerebral cortex0
0
Hspb2HIPHippocampal region0
0
Hspb2HPFHippocampal formation0
0
Hspb2HYHypothalamus0
0
Hspb2LSXLateral septal complex0
0
Hspb2MBMidbrain0
0
Hspb2MYMedulla0
0
Hspb2OLFOlfactory bulb0
0
Hspb2PPons0
0
Hspb2PALPallidum0
0
Hspb2RHPRetrohippocampal region0
0
Hspb2sAMYStriatum-like amygdalar nuclei0
0
Hspb2STRStriatum0
0
Hspb2STRdStriatum dorsal region0
0
Hspb2STRvStriatum ventral region0
0
Hspb2THThalamus0
0
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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