AutismKB 2.0

Annotation Detail for HSP90AA1


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Basic Information Top
Gene Symbol:HSP90AA1 ( FLJ31884,HSP86,HSP89A,HSP90A,HSP90N,HSPC1,HSPCA,HSPCAL1,HSPCAL4,HSPN,Hsp89,Hsp90,LAP2 )
Gene Full Name: heat shock protein 90kDa alpha (cytosolic), class A member 1
Band: 14q32.31
Quick LinksEntrez ID:3320; OMIM: 140571; Uniprot ID:HS90A_HUMAN; ENSEMBL ID: ENSG00000080824; HGNC ID: 5253
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body43 / 70761607
blastocyst19 / 62319304
fetus515 / 564012913
neonate19 / 31097610
infant30 / 236201270
juvenile156 / 555562807
adult1624 / 1939121837
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor3 / 12794234
bladder carcinoma11 / 17475629
breast (mammary gland) tumor143 / 941781518
cervical tumor13 / 34366378
chondrosarcoma75 / 82823905
colorectal tumor101 / 114246884
esophageal tumor144 / 172908328
gastrointestinal tumor200 / 1193691675
germ cell tumor195 / 263845739
glioma60 / 106883561
head and neck tumor224 / 1363021643
kidney tumor81 / 689591174
leukemia127 / 958421325
liver tumor155 / 963591608
lung tumor89 / 103127863
lymphoma46 / 71755641
non-neoplasia44 / 97250452
normal2350 / 3360307699
ovarian tumor57 / 76682743
pancreatic tumor47 / 104616449
primitive neuroectodermal tumor of the CNS127 / 1256801010
prostate cancer74 / 102680720
retinoblastoma23 / 46356496
skin tumor165 / 1249491320
soft tissue/muscle tissue tumor156 / 1251911246
uterine tumor48 / 90257531
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue17 / 131061297
adrenal gland24 / 33197722
ascites123 / 400153073
bladder34 / 297571142
blood83 / 123478672
bone60 / 71655837
bone marrow109 / 488012233
brain1552 / 11009891409
cervix15 / 48171311
connective tissue142 / 149255951
ear8 / 16212493
embryonic tissue109 / 215722505
esophagus144 / 202097125
eye89 / 211054421
heart75 / 89626836
intestine163 / 234472695
kidney164 / 211777774
larynx11 / 24145455
liver236 / 2077431136
lung357 / 3369741059
lymph19 / 44270429
lymph node26 / 91610283
mammary gland227 / 1532711481
mouth98 / 670521461
muscle39 / 107715362
nerve18 / 157681141
ovary69 / 102051676
pancreas71 / 214812330
parathyroid6 / 20539292
pharynx114 / 413282758
pituitary gland12 / 16585723
placenta128 / 280825455
prostate131 / 189345691
salivary gland8 / 20155396
skin200 / 210574949
spleen18 / 53952333
stomach81 / 96619838
testis365 / 3304421104
thymus97 / 811311195
thyroid21 / 47473442
tonsil9 / 16999529
trachea32 / 52413610
umbilical cord11 / 13680804
uterus145 / 232878622
vascular59 / 517801139
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 211969_at
Cell line Expression level Expression bar
721_B_lymphoblasts5385.5
Adipocyte1137.85
AdrenalCortex1859.95
Adrenalgland287.55
Amygdala4690.65
Appendix363.2
AtrioventricularNode2201.9
BDCA4+_DentriticCells2264.35
Bonemarrow579.55
BronchialEpithelialCells3322.25
CD105+_Endothelial6003.2
CD14+_Monocytes1318.95
CD19+_BCells(neg._sel.)1846.45
CD33+_Myeloid2994.25
CD34+4692.65
CD4+_Tcells2487.65
CD56+_NKCells2807.05
CD71+_EarlyErythroid2975.35
CD8+_Tcells2083.65
CardiacMyocytes1446.9
Caudatenucleus2118.7
Cerebellum404.25
CerebellumPeduncles974.55
CiliaryGanglion1130.9
CingulateCortex6970.7
Colorectaladenocarcinoma4374.05
DorsalRootGanglion1070.85
FetalThyroid983.85
Fetalbrain2668.25
Fetalliver1461.15
Fetallung1316.7
GlobusPallidus2748.85
Heart12.6
Hypothalamus5238.35
Kidney251.85
Leukemia_chronicMyelogenousK-5621517.5
Leukemia_promyelocytic-HL-601904.65
Leukemialymphoblastic(MOLT-4)1812.9
Liver291.85
Lung396.65
Lymphnode827.95
Lymphoma_burkitts(Daudi)1693.7
Lymphoma_burkitts(Raji)1482.1
MedullaOblongata3020.35
OccipitalLobe4256.85
OlfactoryBulb6343.1
Ovary467.85
Pancreas1961.15
PancreaticIslet2607
ParietalLobe5057.6
Pituitary2860.95
Placenta413.6
Pons2557.3
PrefrontalCortex5835.95
Prostate2817.35
Salivarygland566.25
SkeletalMuscle922.2
Skin334.75
SmoothMuscle1977.65
Spinalcord1341.55
SubthalamicNucleus2962.1
SuperiorCervicalGanglion419.3
TemporalLobe2261.8
Testis577.85
TestisGermCell5181.95
TestisIntersitial5461.65
TestisLeydigCell3191.45
TestisSeminiferousTubule4465.15
Thalamus3108.75
Thymus813.7
Thyroid1136.55
Tongue955.65
Tonsil1578.75
Trachea1274.65
TrigeminalGanglion1643.1
Uterus1790.5
UterusCorpus788.2
WholeBlood681.6
Wholebrain1319.2
colon1015.55
pineal_day5483.06
pineal_night4680.6
retina2084.875
small_intestine502.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P145377
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala11.55 ± 0.35
Basal Forebrain11.7 ± 0.17
Basal Part of Pons11.98 ± 0.34
Cerebellar Cortex11.44 ± 0.2
Cerebellar Nuclei11.9 ± 0.31
Claustrum12.16 ± 0.4
Epithalamus12.06 ± 0.49
Frontal Lobe11.94 ± 0.37
Globus Pallidus11.91 ± 0.22
Hypothalamus11.84 ± 0.33
Insula11.89 ± 0.31
Limbic Lobe11.8 ± 0.49
Mesencephalon11.85 ± 0.45
Myelencephalon11.74 ± 0.42
Occipital Lobe11.45 ± 0.45
Parietal Lobe11.72 ± 0.34
Pontine Tegmentum11.78 ± 0.39
Striatum11.93 ± 0.45
Subthalamus12.19 ± 0.34
Temporal Lobe11.75 ± 0.35
Thalamus11.86 ± 0.33
White Matter12.3 ± 0.09
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Hsp90aa1CBCerebellum64.77
100
Hsp90aa1CTXCerebral cortex100
100
Hsp90aa1HIPHippocampal region100
100
Hsp90aa1HPFHippocampal formation100
100
Hsp90aa1HYHypothalamus100
100
Hsp90aa1LSXLateral septal complex100
100
Hsp90aa1MBMidbrain100
100
Hsp90aa1MYMedulla100
100
Hsp90aa1OLFOlfactory bulb100
100
Hsp90aa1PPons100
100
Hsp90aa1PALPallidum100
100
Hsp90aa1RHPRetrohippocampal region100
100
Hsp90aa1sAMYStriatum-like amygdalar nuclei100
100
Hsp90aa1STRStriatum100
100
Hsp90aa1STRdStriatum dorsal region100
100
Hsp90aa1STRvStriatum ventral region100
100
Hsp90aa1THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
HS90A_HUMAN_0 0 0 0 ADLINNLGTIAK PRIDE
HS90A_HUMAN_0 0 0 0 DQVANSAFVER PRIDE
HS90A_HUMAN_0 0 0 0 ELISNSSDALDKIR PRIDE
HS90A_HUMAN_0 0 0 0 GVVDSEDLPLNISR PRIDE
HS90A_HUMAN_0 0 0 0 HFSVEGQLEFR PRIDE
HS90A_HUMAN_0 0 0 0 HLEINPDHSIIETLR PRIDE
HS90A_HUMAN_0 0 0 0 HSQFIGYPITLFVEK PRIDE
HS90A_HUMAN_0 0 0 0 NPDDITNEEYGEFYK PRIDE
HS90A_HUMAN_0 0 0 0 SLTNDWEDHLAVK PRIDE
HS90A_HUMAN_0 0 0 0 VILHLKEDQTEYLEER PRIDE
HS90A_HUMAN_100 12 100 111 ADLINNLGTIAK PRIDE
HS90A_HUMAN_100 16 100 115 ADLINNLGTIAKSGTK PRIDE
HS90A_HUMAN_101 12 101 112 ADLINNLGTIAK PRIDE
HS90A_HUMAN_148 26 148 173 VTVITKHNDDEQYAWESSAGGSFTVR PRIDE
HS90A_HUMAN_153 20 153 172 HNDDEQYAWESSAGGSFTVR PRIDE
HS90A_HUMAN_173 9 173 181 TDTGEPMGR PRIDE
HS90A_HUMAN_174 9 174 182 TDTGEPMGR PRIDE
HS90A_HUMAN_182 19 182 200 GTKVILHLKEDQTEYLEER PRIDE
HS90A_HUMAN_185 16 185 200 VILHLKEDQTEYLEER PRIDE
HS90A_HUMAN_185 17 185 201 VILHLKEDQTEYLEERR PRIDE
HS90A_HUMAN_190 11 190 200 KEDQTEYLEER PRIDE
HS90A_HUMAN_191 10 191 200 EDQTEYLEER PRIDE
HS90A_HUMAN_209 15 209 223 HSQFIGYPITLFVEK PRIDE
HS90A_HUMAN_209 17 209 225 HSQFIGYPITLFVEKER PRIDE
HS90A_HUMAN_281 18 281 298 EKYIDQEELNKTKPIWTR PRIDE
HS90A_HUMAN_283 16 283 298 YIDQEELNKTKPIWTR PRIDE
HS90A_HUMAN_283 9 283 291 YIDQEELNK PRIDE
HS90A_HUMAN_284 9 284 292 YIDQEELNK PRIDE
HS90A_HUMAN_292 22 292 313 TKPIWTRNPDDITNEEYGEFYK PRIDE
HS90A_HUMAN_292 7 292 298 TKPIWTR PRIDE
HS90A_HUMAN_299 15 299 313 NPDDITNEEYGEFYK PRIDE
HS90A_HUMAN_314 13 314 326 SLTNDWEDHLAVK PRIDE
HS90A_HUMAN_314 24 314 337 SLTNDWEDHLAVKHFSVEGQLEFR PRIDE
HS90A_HUMAN_315 13 315 327 SLTNDWEDHLAVK PRIDE
HS90A_HUMAN_327 11 327 337 HFSVEGQLEFR PRIDE
HS90A_HUMAN_328 11 328 338 HFSVEGQLEFR PRIDE
HS90A_HUMAN_338 7 338 344 ALLFVPR PRIDE
HS90A_HUMAN_339 7 339 345 ALLFVPR PRIDE
HS90A_HUMAN_345 10 345 354 RAPFDLFENR PRIDE
HS90A_HUMAN_345 11 345 355 RAPFDLFENRK PRIDE
HS90A_HUMAN_346 9 346 354 APFDLFENR PRIDE
HS90A_HUMAN_366 20 366 385 RVFIMDNCEELIPEYLNFIR PRIDE
HS90A_HUMAN_367 19 367 385 VFIMDNCEELIPEYLNFIR PRIDE
HS90A_HUMAN_386 14 386 399 GVVDSEDLPLNISR PRIDE
HS90A_HUMAN_387 14 387 400 GVVDSEDLPLNISR PRIDE
HS90A_HUMAN_401 13 401 413 EMLQQSKILKVIR PRIDE
HS90A_HUMAN_419 17 419 435 CLELFTELAEDKENYKK PRIDE
HS90A_HUMAN_42 17 42 58 EIFLRELISNSSDALDK PRIDE
HS90A_HUMAN_420 12 420 431 CLELFTELAEDK PRIDE
HS90A_HUMAN_441 15 441 455 SKNIKLGIHEDSQNR PRIDE
HS90A_HUMAN_443 14 443 456 NIKLGIHEDSQNRK PRIDE
HS90A_HUMAN_45 15 45 59 RELISNSSDALDKIR PRIDE
HS90A_HUMAN_456 8 456 463 KKLSELLR PRIDE
HS90A_HUMAN_457 8 457 464 KKLSELLR PRIDE
HS90A_HUMAN_459 6 459 464 LSELLR PRIDE
HS90A_HUMAN_46 12 46 57 ELISNSSDALDK PRIDE
HS90A_HUMAN_46 14 46 59 ELISNSSDALDKIR PRIDE
HS90A_HUMAN_464 14 464 477 YYTSASGDEMVSLK PRIDE
HS90A_HUMAN_464 19 464 482 YYTSASGDEMVSLKDYCTR PRIDE
HS90A_HUMAN_47 12 47 58 ELISNSSDALDK PRIDE
HS90A_HUMAN_47 13 47 59 LISNSSDALDKIR PRIDE
HS90A_HUMAN_47 14 47 60 ELISNSSDALDKIR PRIDE
HS90A_HUMAN_489 10 489 498 HIYYITGETK PRIDE
HS90A_HUMAN_489 21 489 509 HIYYITGETKDQVANSAFVER PRIDE
HS90A_HUMAN_490 10 490 499 HIYYITGETK PRIDE
HS90A_HUMAN_490 21 490 510 HIYYITGETKDQVANSAFVER PRIDE
HS90A_HUMAN_499 11 499 509 DQVANSAFVER PRIDE
HS90A_HUMAN_500 11 500 510 DQVANSAFVER PRIDE
HS90A_HUMAN_512 22 512 533 KHGLEVIYMIEPIDEYCVQQLK PRIDE
HS90A_HUMAN_513 21 513 533 HGLEVIYMIEPIDEYCVQQLK PRIDE
HS90A_HUMAN_513 26 513 538 HGLEVIYMIEPIDEYCVQQLKEFEGK PRIDE
HS90A_HUMAN_514 21 514 534 HGLEVIYMIEPIDEYCVQQLK PRIDE
HS90A_HUMAN_573 8 573 580 IMKDILEK PRIDE
HS90A_HUMAN_58 16 58 73 IRYESLTDPSKLDSGK PRIDE
HS90A_HUMAN_582 9 582 590 VEKVVVSNR PRIDE
HS90A_HUMAN_591 21 591 611 LVTSPCCIVTSTYGWTANMER PRIDE
HS90A_HUMAN_60 14 60 73 YESLTDPSKLDSGK PRIDE
HS90A_HUMAN_613 8 613 620 IMKAQALR PRIDE
HS90A_HUMAN_620 11 620 630 DNSTMGYMAAK PRIDE
HS90A_HUMAN_631 16 631 646 KHLEINPDHSIIETLR PRIDE
HS90A_HUMAN_632 15 632 646 HLEINPDHSIIETLR PRIDE
HS90A_HUMAN_633 15 633 647 HLEINPDHSIIETLR PRIDE
HS90A_HUMAN_74 13 74 86 ELHINLIPNKQDR PRIDE
HS90A_HUMAN_85 16 85 100 QDRTLTIVDTGIGMTK PRIDE
HS90A_HUMAN_87 13 87 99 TLTIVDTGIGMTK PRIDE
HS90A_HUMAN_87 25 87 111 TLTIVDTGIGMTKADLINNLGTIAK PRIDE
HS90A_HUMAN_88 13 88 100 TLTIVDTGIGMTK PRIDE
PAp00003306 11 328 338 HFSVEGQLEFR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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