AutismKB 2.0

Annotation Detail for HSPG2


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Basic Information Top
Gene Symbol:HSPG2 ( PLC,PRCAN,SJA,SJS,SJS1 )
Gene Full Name: heparan sulfate proteoglycan 2
Band: 1p36.12
Quick LinksEntrez ID:3339; OMIM: 142461; Uniprot ID:PGBM_HUMAN; ENSEMBL ID: ENSG00000142798; HGNC ID: 5273
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body29 / 70761409
blastocyst9 / 62319144
fetus26 / 56401246
neonate1 / 3109732
infant0 / 236200 
juvenile9 / 55556161
adult210 / 1939121108
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma6 / 17475343
breast (mammary gland) tumor5 / 9417853
cervical tumor0 / 343660 
chondrosarcoma7 / 8282384
colorectal tumor26 / 114246227
esophageal tumor2 / 17290115
gastrointestinal tumor11 / 11936992
germ cell tumor10 / 26384537
glioma6 / 10688356
head and neck tumor10 / 13630273
kidney tumor10 / 68959145
leukemia2 / 9584220
liver tumor6 / 9635962
lung tumor12 / 103127116
lymphoma0 / 717550 
non-neoplasia8 / 9725082
normal277 / 336030782
ovarian tumor7 / 7668291
pancreatic tumor28 / 104616267
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer10 / 10268097
retinoblastoma0 / 463560 
skin tumor27 / 124949216
soft tissue/muscle tissue tumor14 / 125191111
uterine tumor32 / 90257354
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue6 / 13106457
adrenal gland2 / 3319760
ascites1 / 4001524
bladder6 / 29757201
blood2 / 12347816
bone10 / 71655139
bone marrow0 / 488010 
brain32 / 110098929
cervix0 / 481710 
connective tissue7 / 14925546
ear0 / 162120 
embryonic tissue50 / 215722231
esophagus2 / 2020998
eye19 / 21105490
heart10 / 89626111
intestine35 / 234472149
kidney16 / 21177775
larynx2 / 2414582
liver8 / 20774338
lung30 / 33697489
lymph0 / 442700 
lymph node0 / 916100 
mammary gland12 / 15327178
mouth7 / 67052104
muscle20 / 107715185
nerve13 / 15768824
ovary10 / 10205197
pancreas36 / 214812167
parathyroid0 / 205390 
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta31 / 280825110
prostate18 / 18934595
salivary gland0 / 201550 
skin34 / 210574161
spleen4 / 5395274
stomach16 / 96619165
testis11 / 33044233
thymus1 / 8113112
thyroid7 / 47473147
tonsil0 / 169990 
trachea10 / 52413190
umbilical cord0 / 136800 
uterus50 / 232878214
vascular6 / 51780115
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201655_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts10.5
Adipocyte379.15
AdrenalCortex196.8
Adrenalgland168.25
Amygdala8.6
Appendix118.55
AtrioventricularNode41.95
BDCA4+_DentriticCells10.25
Bonemarrow9.65
BronchialEpithelialCells32.1
CD105+_Endothelial8.7
CD14+_Monocytes9.9
CD19+_BCells(neg._sel.)9.45
CD33+_Myeloid10.9
CD34+26.9
CD4+_Tcells9.25
CD56+_NKCells10.5
CD71+_EarlyErythroid11.5
CD8+_Tcells8.05
CardiacMyocytes299.5
Caudatenucleus8.2
Cerebellum7.45
CerebellumPeduncles10.9
CiliaryGanglion65.7
CingulateCortex9.5
Colorectaladenocarcinoma17.6
DorsalRootGanglion152.55
FetalThyroid531.9
Fetalbrain12.25
Fetalliver13
Fetallung162.4
GlobusPallidus7.8
Heart431.9
Hypothalamus9.2
Kidney42.75
Leukemia_chronicMyelogenousK-56253.55
Leukemia_promyelocytic-HL-607.9
Leukemialymphoblastic(MOLT-4)7.1
Liver76.6
Lung306.55
Lymphnode52.95
Lymphoma_burkitts(Daudi)12
Lymphoma_burkitts(Raji)12.05
MedullaOblongata8
OccipitalLobe8.1
OlfactoryBulb348.75
Ovary14.85
Pancreas35.95
PancreaticIslet57.95
ParietalLobe10.1
Pituitary16.55
Placenta247.15
Pons13.7
PrefrontalCortex10.9
Prostate243.95
Salivarygland7.6
SkeletalMuscle32.2
Skin20.4
SmoothMuscle621.45
Spinalcord29.05
SubthalamicNucleus19.35
SuperiorCervicalGanglion15.85
TemporalLobe14.65
Testis13.35
TestisGermCell40.1
TestisIntersitial18.7
TestisLeydigCell23.45
TestisSeminiferousTubule14.6
Thalamus26.3
Thymus61.3
Thyroid278.6
Tongue20.8
Tonsil22.15
Trachea41.05
TrigeminalGanglion57.4
Uterus404.1
UterusCorpus27.1
WholeBlood8.85
Wholebrain6.7
colon73.95
pineal_day11.28
pineal_night12.18
retina97.95
small_intestine56.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_338_PI416408490
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala1.95 ± 1.03
Basal Forebrain1.59 ± 0.35
Basal Part of Pons1.19 ± 0.41
Cerebellar Cortex1.35 ± 0.71
Cerebellar Nuclei1.79 ± 0.73
Claustrum2.28 ± 0.77
Epithalamus1.23 ± 0.74
Frontal Lobe1.37 ± 0.62
Globus Pallidus2.18 ± 0.34
Hypothalamus1.67 ± 0.8
Insula1.46 ± 0.57
Limbic Lobe1.52 ± 0.72
Mesencephalon1.7 ± 0.78
Myelencephalon1.55 ± 0.67
Occipital Lobe1.48 ± 0.53
Parietal Lobe1.58 ± 0.77
Pontine Tegmentum1.56 ± 0.62
Striatum1.67 ± 0.48
Subthalamus1.61 ± 0.61
Temporal Lobe1.44 ± 0.66
Thalamus1.51 ± 0.6
White Matter2.29 ± 0.69
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00000304 10 3652 3661 AFAHLQVPER Peptide Atlas
PGBM_HUMAN_3258 10 3258 3267 LEGDTLIIPR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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