AutismKB 2.0

Annotation Detail for APOA1


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Basic Information Top
Gene Symbol:APOA1 ( MGC117399 )
Gene Full Name: apolipoprotein A-I
Band: 11q23.3
Quick LinksEntrez ID:335; OMIM: 107680; Uniprot ID:APOA1_HUMAN; ENSEMBL ID: ENSG00000118137; HGNC ID: 600
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst1 / 6231916
fetus148 / 564012262
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult315 / 1939121162
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor11 / 26384541
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia4 / 9584241
liver tumor87 / 96359902
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal493 / 3360307146
ovarian tumor4 / 7668252
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood4 / 12347832
bone0 / 716550 
bone marrow0 / 488010 
brain13 / 110098911
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue5 / 21572223
esophagus0 / 202090 
eye0 / 2110540 
heart5 / 8962655
intestine2 / 2344728
kidney0 / 2117770 
larynx0 / 241450 
liver412 / 2077431983
lung20 / 33697459
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle1 / 1077159
nerve0 / 157680 
ovary6 / 10205158
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta6 / 28082521
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen33 / 53952611
stomach0 / 966190 
testis37 / 330442111
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204450_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.4
Adipocyte8.55
AdrenalCortex9.55
Adrenalgland11.45
Amygdala9.15
Appendix8.45
AtrioventricularNode6.2
BDCA4+_DentriticCells6
Bonemarrow8.4
BronchialEpithelialCells8.5
CD105+_Endothelial7.3
CD14+_Monocytes6.35
CD19+_BCells(neg._sel.)8.55
CD33+_Myeloid11
CD34+10.9
CD4+_Tcells8.25
CD56+_NKCells7.9
CD71+_EarlyErythroid8
CD8+_Tcells8.2
CardiacMyocytes10.8
Caudatenucleus8.6
Cerebellum7.2
CerebellumPeduncles10.45
CiliaryGanglion5.9
CingulateCortex8.75
Colorectaladenocarcinoma8.55
DorsalRootGanglion5.75
FetalThyroid8.35
Fetalbrain8.6
Fetalliver4014.55
Fetallung1547.1
GlobusPallidus7.3
Heart61.15
Hypothalamus9.35
Kidney7.7
Leukemia_chronicMyelogenousK-5627.8
Leukemia_promyelocytic-HL-607.65
Leukemialymphoblastic(MOLT-4)6.9
Liver31286.45
Lung9.45
Lymphnode7.4
Lymphoma_burkitts(Daudi)11.05
Lymphoma_burkitts(Raji)12
MedullaOblongata7.9
OccipitalLobe7.75
OlfactoryBulb6.8
Ovary4.75
Pancreas9.3
PancreaticIslet9.5
ParietalLobe9.2
Pituitary11.8
Placenta7.05
Pons8.1
PrefrontalCortex9.6
Prostate29.05
Salivarygland6.85
SkeletalMuscle9.8
Skin5.7
SmoothMuscle9.75
Spinalcord9.15
SubthalamicNucleus7.85
SuperiorCervicalGanglion9.6
TemporalLobe7.9
Testis360.9
TestisGermCell486.25
TestisIntersitial60.6
TestisLeydigCell108.8
TestisSeminiferousTubule191.95
Thalamus10.15
Thymus6.3
Thyroid10.8
Tongue8.45
Tonsil8.35
Trachea12.2
TrigeminalGanglion8.4
Uterus7.2
UterusCorpus7.6
WholeBlood9.4
Wholebrain7.3
colon8.85
pineal_day9.62
pineal_night9.76
retina10.4
small_intestine1566.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16581_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.65 ± 0.64
Basal Forebrain6.41 ± 0.26
Basal Part of Pons6.68 ± 0.34
Cerebellar Cortex6.23 ± 0.46
Cerebellar Nuclei6.61 ± 0.2
Claustrum6.62 ± 0.4
Epithalamus5.84 ± 0.45
Frontal Lobe6.46 ± 0.43
Globus Pallidus6.86 ± 0.51
Hypothalamus6.23 ± 0.46
Insula6.29 ± 0.41
Limbic Lobe6.53 ± 0.47
Mesencephalon6.38 ± 0.41
Myelencephalon6.48 ± 0.48
Occipital Lobe6.4 ± 0.53
Parietal Lobe6.37 ± 0.45
Pontine Tegmentum6.26 ± 0.45
Striatum6.56 ± 0.5
Subthalamus6.4 ± 0.29
Temporal Lobe6.36 ± 0.5
Thalamus6.55 ± 0.35
White Matter6.43 ± 0.33
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Apoa1CBCerebellum0.42
0.61
Apoa1CTXCerebral cortex0.49
0.75
Apoa1HIPHippocampal region0.17
0.18
Apoa1HPFHippocampal formation0.16
0.19
Apoa1HYHypothalamus0.19
0.15
Apoa1LSXLateral septal complex0.11
0.07
Apoa1MBMidbrain0.6
0.79
Apoa1MYMedulla3.19
3.97
Apoa1OLFOlfactory bulb0.29
0.29
Apoa1PPons2.34
2.83
Apoa1PALPallidum0.12
0.18
Apoa1RHPRetrohippocampal region0.14
0.19
Apoa1sAMYStriatum-like amygdalar nuclei0.1
0.03
Apoa1STRStriatum0.17
0.24
Apoa1STRdStriatum dorsal region0.21
0.33
Apoa1STRvStriatum ventral region0.12
0.1
Apoa1THThalamus1.79
2.55
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
APOA1_HUMAN_121 10 121 130 VQPYLDDFQK PRIDE
APOA1_HUMAN_121 11 121 131 VQPYLDDFQKK PRIDE
APOA1_HUMAN_132 9 132 140 WQEEMELYR PRIDE
APOA1_HUMAN_165 9 165 173 LSPLGEEMR PRIDE
APOA1_HUMAN_185 11 185 195 THLAPYSDELR PRIDE
APOA1_HUMAN_213 18 213 230 LAEYHAKATEHLSTLSEK PRIDE
APOA1_HUMAN_220 11 220 230 ATEHLSTLSEK PRIDE
APOA1_HUMAN_231 9 231 239 AKPALEDLR PRIDE
APOA1_HUMAN_240 11 240 250 QGLLPVLESFK PRIDE
APOA1_HUMAN_251 12 251 262 VSFLSALEEYTK PRIDE
APOA1_HUMAN_35 13 35 47 VKDLATVYVDVLK PRIDE
APOA1_HUMAN_37 15 37 51 DLATVYVDVLKDSGR PRIDE
APOA1_HUMAN_37 28 37 64 DLATVYVDVLKDSGRDYVSQFEGSALGK PRIDE
APOA1_HUMAN_48 17 48 64 DSGRDYVSQFEGSALGK PRIDE
APOA1_HUMAN_52 13 52 64 DYVSQFEGSALGK PRIDE
APOA1_HUMAN_70 14 70 83 LLDNWDSVTSTFSK PRIDE
APOA1_HUMAN_84 18 84 101 LREQLGPVTQEFWDNLEK PRIDE
APOA1_HUMAN_84 24 84 107 LREQLGPVTQEFWDNLEKETEGLR PRIDE
APOA1_HUMAN_86 16 86 101 EQLGPVTQEFWDNLEK PRIDE
APOA1_HUMAN_86 22 86 107 EQLGPVTQEFWDNLEKETEGLR PRIDE
APOA1_HUMAN_90 12 90 101 PVTQEFWDNLEK PRIDE
PAp00024103 7 178 184 AHVDALR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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