AutismKB 2.0

Annotation Detail for HTR1B


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Basic Information Top
Gene Symbol:HTR1B ( 5-HT1B,5-HT1DB,HTR1D2,HTR1DB,S12 )
Gene Full Name: 5-hydroxytryptamine (serotonin) receptor 1B
Band: 6q14.1
Quick LinksEntrez ID:3351; OMIM: 182131; Uniprot ID:5HT1B_HUMAN; ENSEMBL ID: ENSG00000135312; HGNC ID: 5287
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus3 / 5640125
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult1 / 19391210 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal5 / 33603071
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain3 / 11009892
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine1 / 2344724
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210799_at
Cell line Expression level Expression bar
721_B_lymphoblasts9.15
Adipocyte7.8
AdrenalCortex8.25
Adrenalgland6.75
Amygdala8.3
Appendix7.9
AtrioventricularNode6.15
BDCA4+_DentriticCells8.15
Bonemarrow9.65
BronchialEpithelialCells7.4
CD105+_Endothelial7.8
CD14+_Monocytes8.3
CD19+_BCells(neg._sel.)8.2
CD33+_Myeloid9.45
CD34+9.75
CD4+_Tcells8.35
CD56+_NKCells9.05
CD71+_EarlyErythroid7.35
CD8+_Tcells7.05
CardiacMyocytes9.95
Caudatenucleus7.1
Cerebellum6.4
CerebellumPeduncles9.05
CiliaryGanglion5.65
CingulateCortex8.1
Colorectaladenocarcinoma7.9
DorsalRootGanglion6.05
FetalThyroid7.65
Fetalbrain7.8
Fetalliver8.9
Fetallung6.45
GlobusPallidus5.75
Heart17.35
Hypothalamus8.55
Kidney6.55
Leukemia_chronicMyelogenousK-5627.15
Leukemia_promyelocytic-HL-606.8
Leukemialymphoblastic(MOLT-4)6.35
Liver14.9
Lung8.8
Lymphnode6.85
Lymphoma_burkitts(Daudi)9.95
Lymphoma_burkitts(Raji)11.2
MedullaOblongata7.25
OccipitalLobe7.15
OlfactoryBulb6.05
Ovary5.3
Pancreas6.45
PancreaticIslet8.45
ParietalLobe8.3
Pituitary9.25
Placenta8.25
Pons7.65
PrefrontalCortex9.9
Prostate11.2
Salivarygland6.3
SkeletalMuscle11.6
Skin6.1
SmoothMuscle9.05
Spinalcord8.45
SubthalamicNucleus7.25
SuperiorCervicalGanglion9.25
TemporalLobe7.2
Testis7.25
TestisGermCell6.65
TestisIntersitial6.65
TestisLeydigCell7.75
TestisSeminiferousTubule6.8
Thalamus8
Thymus6.2
Thyroid9.85
Tongue7.9
Tonsil7.7
Trachea6.65
TrigeminalGanglion8.25
Uterus6.5
UterusCorpus8.45
WholeBlood8.65
Wholebrain6.75
colon7.9
pineal_day9.5
pineal_night9.6
retina9.55
small_intestine7.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P156824
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.28 ± 0.87
Basal Forebrain2.87 ± 0.5
Basal Part of Pons3.01 ± 0.7
Cerebellar Cortex2.66 ± 0.67
Cerebellar Nuclei2.93 ± 0.57
Claustrum3.56 ± 0.78
Epithalamus2.91 ± 0.67
Frontal Lobe2.89 ± 0.8
Globus Pallidus2.86 ± 0.79
Hypothalamus2.54 ± 0.65
Insula2.67 ± 0.55
Limbic Lobe2.89 ± 0.71
Mesencephalon3.05 ± 0.71
Myelencephalon2.95 ± 0.77
Occipital Lobe3.41 ± 0.8
Parietal Lobe2.85 ± 0.69
Pontine Tegmentum2.91 ± 0.7
Striatum3.27 ± 0.72
Subthalamus2.8 ± 0.77
Temporal Lobe2.88 ± 0.73
Thalamus3.06 ± 0.7
White Matter2.63 ± 0.51
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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