AutismKB 2.0

Annotation Detail for HTR3A


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Basic Information Top
Gene Symbol:HTR3A ( 5-HT-3,5-HT3A,5-HT3R,5HT3R,HTR3 )
Gene Full Name: 5-hydroxytryptamine (serotonin) receptor 3A
Band: 11q23.2
Quick LinksEntrez ID:3359; OMIM: 182139; Uniprot ID:5HT3A_HUMAN; ENSEMBL ID: ENSG00000166736; HGNC ID: 5297
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus8 / 56401214
neonate0 / 310970 
infant1 / 2362042
juvenile0 / 555560 
adult7 / 19391213
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor4 / 26384515
glioma0 / 1068830 
head and neck tumor1 / 1363027
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor14 / 103127135
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal24 / 33603077
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS8 / 12568063
prostate cancer0 / 1026800 
retinoblastoma2 / 4635643
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood1 / 1234788
bone0 / 716550 
bone marrow0 / 488010 
brain5 / 11009894
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye2 / 2110549
heart0 / 896260 
intestine2 / 2344728
kidney1 / 2117774
larynx1 / 2414541
liver0 / 2077430 
lung14 / 33697441
lymph0 / 442700 
lymph node3 / 9161032
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach1 / 9661910
testis3 / 3304429
thymus1 / 8113112
thyroid0 / 474730 
tonsil3 / 16999176
trachea0 / 524130 
umbilical cord0 / 136800 
uterus1 / 2328784
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 217002_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.95
Adipocyte4
AdrenalCortex4.25
Adrenalgland3.4
Amygdala4.3
Appendix4.05
AtrioventricularNode3.05
BDCA4+_DentriticCells7.3
Bonemarrow4.15
BronchialEpithelialCells4
CD105+_Endothelial4.05
CD14+_Monocytes4.25
CD19+_BCells(neg._sel.)4.35
CD33+_Myeloid5.2
CD34+5.1
CD4+_Tcells4.5
CD56+_NKCells4.85
CD71+_EarlyErythroid3.8
CD8+_Tcells3.85
CardiacMyocytes5.35
Caudatenucleus3.6
Cerebellum3.25
CerebellumPeduncles4.55
CiliaryGanglion2.85
CingulateCortex4.1
Colorectaladenocarcinoma4.05
DorsalRootGanglion3.1
FetalThyroid3.9
Fetalbrain4
Fetalliver3.55
Fetallung3.35
GlobusPallidus3
Heart5.6
Hypothalamus4.3
Kidney3.25
Leukemia_chronicMyelogenousK-5623.65
Leukemia_promyelocytic-HL-603.55
Leukemialymphoblastic(MOLT-4)3.2
Liver5.4
Lung4.4
Lymphnode3.5
Lymphoma_burkitts(Daudi)5.1
Lymphoma_burkitts(Raji)5.8
MedullaOblongata3.65
OccipitalLobe3.6
OlfactoryBulb3.2
Ovary2.65
Pancreas3.2
PancreaticIslet4.35
ParietalLobe4.25
Pituitary4.65
Placenta4.1
Pons3.8
PrefrontalCortex5.05
Prostate4.7
Salivarygland3.2
SkeletalMuscle4.65
Skin3.15
SmoothMuscle4.55
Spinalcord4.3
SubthalamicNucleus3.65
SuperiorCervicalGanglion4.7
TemporalLobe3.65
Testis3.45
TestisGermCell3.3
TestisIntersitial3.3
TestisLeydigCell3.95
TestisSeminiferousTubule3.45
Thalamus4.05
Thymus3.15
Thyroid5.1
Tongue3.9
Tonsil3.9
Trachea3.4
TrigeminalGanglion4
Uterus3.3
UterusCorpus3.85
WholeBlood4.45
Wholebrain3.35
colon4.05
pineal_day5
pineal_night4.92
retina4.85
small_intestine3.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_805_PI417557136
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.23 ± 0.95
Basal Forebrain1.81 ± 0.2
Basal Part of Pons1.55 ± 0.49
Cerebellar Cortex1.75 ± 0.82
Cerebellar Nuclei2.15 ± 0.72
Claustrum2.7 ± 0.77
Epithalamus1.54 ± 0.8
Frontal Lobe1.72 ± 0.65
Globus Pallidus2.61 ± 0.62
Hypothalamus1.94 ± 0.66
Insula1.69 ± 0.44
Limbic Lobe1.91 ± 0.7
Mesencephalon2.07 ± 0.76
Myelencephalon1.91 ± 0.72
Occipital Lobe1.85 ± 0.62
Parietal Lobe2 ± 0.94
Pontine Tegmentum1.95 ± 0.72
Striatum2.07 ± 0.58
Subthalamus2.01 ± 0.68
Temporal Lobe1.72 ± 0.66
Thalamus1.82 ± 0.6
White Matter2.16 ± 0.25
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Htr3aCBCerebellum3.62
4.52
Htr3aCTXCerebral cortex5.36
5.44
Htr3aHIPHippocampal region10.01
14.95
Htr3aHPFHippocampal formation8.59
11.37
Htr3aHYHypothalamus0.4
0.36
Htr3aLSXLateral septal complex0.98
1.26
Htr3aMBMidbrain0.61
0.96
Htr3aMYMedulla1.98
2.88
Htr3aOLFOlfactory bulb6.78
6.07
Htr3aPPons0.7
1.19
Htr3aPALPallidum0.6
0.53
Htr3aRHPRetrohippocampal region6.58
6.96
Htr3asAMYStriatum-like amygdalar nuclei2.21
2.2
Htr3aSTRStriatum1.33
1.29
Htr3aSTRdStriatum dorsal region1.3
1.24
Htr3aSTRvStriatum ventral region1.26
1.19
Htr3aTHThalamus0.66
0.8
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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