AutismKB 2.0

Annotation Detail for APOA2


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Basic Information Top
Gene Symbol:APOA2 ( Apo-AII,ApoA-II,apoAII )
Gene Full Name: apolipoprotein A-II
Band: 1q23.3
Quick LinksEntrez ID:336; OMIM: 107670; Uniprot ID:APOA2_HUMAN; ENSEMBL ID: ENSG00000158874; HGNC ID: 601
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst1 / 6231916
fetus330 / 564012585
neonate0 / 310970 
infant0 / 236200 
juvenile5 / 5555689
adult186 / 193912195
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor3 / 26384511
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia2 / 9584220
liver tumor133 / 963591380
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia3 / 9725030
normal524 / 3360307155
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood2 / 12347816
bone0 / 716550 
bone marrow0 / 488010 
brain5 / 11009894
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye0 / 2110540 
heart19 / 89626211
intestine1 / 2344724
kidney3 / 21177714
larynx0 / 241450 
liver276 / 2077431328
lung12 / 33697435
lymph0 / 442700 
lymph node0 / 916100 
mammary gland1 / 1532716
mouth0 / 670520 
muscle2 / 10771518
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta1 / 2808253
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen65 / 539521204
stomach0 / 966190 
testis1 / 3304423
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219465_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.25
Adipocyte5.2
AdrenalCortex6.05
Adrenalgland4.65
Amygdala5.6
Appendix5.4
AtrioventricularNode4.55
BDCA4+_DentriticCells5.45
Bonemarrow5.6
BronchialEpithelialCells5.2
CD105+_Endothelial5.4
CD14+_Monocytes5.6
CD19+_BCells(neg._sel.)5.6
CD33+_Myeloid6.85
CD34+6.45
CD4+_Tcells5.55
CD56+_NKCells6.45
CD71+_EarlyErythroid5.05
CD8+_Tcells5.05
CardiacMyocytes7.45
Caudatenucleus4.75
Cerebellum4.3
CerebellumPeduncles6.2
CiliaryGanglion4
CingulateCortex5.5
Colorectaladenocarcinoma5.3
DorsalRootGanglion4.45
FetalThyroid5.55
Fetalbrain5.3
Fetalliver11675.3
Fetallung2315.7
GlobusPallidus3.9
Heart7.35
Hypothalamus5.7
Kidney4.55
Leukemia_chronicMyelogenousK-5624.8
Leukemia_promyelocytic-HL-604.7
Leukemialymphoblastic(MOLT-4)4.15
Liver19760.25
Lung5.8
Lymphnode4.55
Lymphoma_burkitts(Daudi)6.75
Lymphoma_burkitts(Raji)7.85
MedullaOblongata4.75
OccipitalLobe4.7
OlfactoryBulb4.2
Ovary3.65
Pancreas4.35
PancreaticIslet5.75
ParietalLobe5.6
Pituitary6.2
Placenta5.45
Pons5.1
PrefrontalCortex6.65
Prostate6.35
Salivarygland4.35
SkeletalMuscle6.5
Skin4.4
SmoothMuscle5.95
Spinalcord5.65
SubthalamicNucleus4.95
SuperiorCervicalGanglion6.7
TemporalLobe4.9
Testis4.6
TestisGermCell4.4
TestisIntersitial4.45
TestisLeydigCell5.45
TestisSeminiferousTubule4.55
Thalamus5.45
Thymus4.15
Thyroid6.55
Tongue5.4
Tonsil5.2
Trachea4.45
TrigeminalGanglion5.45
Uterus4.35
UterusCorpus5
WholeBlood5.75
Wholebrain4.4
colon5.35
pineal_day6.52
pineal_night6.4
retina6.45
small_intestine5.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P302249
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.3 ± 1.07
Basal Forebrain1.94 ± 0.27
Basal Part of Pons1.54 ± 0.39
Cerebellar Cortex1.72 ± 0.68
Cerebellar Nuclei2.19 ± 0.73
Claustrum2.85 ± 0.95
Epithalamus1.58 ± 0.84
Frontal Lobe1.78 ± 0.67
Globus Pallidus2.47 ± 0.44
Hypothalamus1.94 ± 0.6
Insula1.81 ± 0.42
Limbic Lobe2.04 ± 0.69
Mesencephalon2.08 ± 0.72
Myelencephalon1.96 ± 0.67
Occipital Lobe1.81 ± 0.62
Parietal Lobe1.85 ± 0.71
Pontine Tegmentum2 ± 0.74
Striatum2.07 ± 0.67
Subthalamus2.1 ± 0.78
Temporal Lobe1.99 ± 0.82
Thalamus1.88 ± 0.73
White Matter2.21 ± 0.22
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Apoa2CBCerebellum1.33
1.77
Apoa2CTXCerebral cortex0.36
0.54
Apoa2HIPHippocampal region1.46
1.4
Apoa2HPFHippocampal formation1.57
1.46
Apoa2HYHypothalamus0.17
0.25
Apoa2LSXLateral septal complex0.09
0.12
Apoa2MBMidbrain0.73
1.63
Apoa2MYMedulla1.58
2.72
Apoa2OLFOlfactory bulb3.16
3.55
Apoa2PPons2.18
4.01
Apoa2PALPallidum0.13
0.11
Apoa2RHPRetrohippocampal region1.97
1.84
Apoa2sAMYStriatum-like amygdalar nuclei0.88
1.41
Apoa2STRStriatum0.36
0.38
Apoa2STRdStriatum dorsal region0.09
0.11
Apoa2STRvStriatum ventral region0.98
0.74
Apoa2THThalamus0.11
0.16
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
APOA2_HUMAN_27 25 27 51 EPCVESLVSQYFQTVTDYGKDLMEK PRIDE
APOA2_HUMAN_68 10 68 77 SKEQLTPLIK PRIDE
PAp00024985 20 27 46 EPCVESLVSQYFQTVTDYGK Peptide Atlas

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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